New Xanthones from Garcinia bracteata and Their Cytotoxicities

Abstract

Two new xanthones, bracthones A (1) and B (2), together with four known xanthones (3-6) were isolated from the stems of Garcinia bracteata. Their structures were elucidated by spectroscopic methods, including extensive 1D-and 2D-NMR techniques. Compounds 1-6 were tested for their cytotoxicities against five human tumor cell lines (NB4, A549, SHSY5Y, PC3, and MCF7).Compounds 1 and 2 showed high cytotoxicities against PC3 cell with IC 50 values of 3.24 and 2.15 μM, respectively.

A New Dihydroxanthenone from the Fermentation Products of Endophytic Fungus of Phomopsis amygdali

“…The configurations of 1R, 2R in 1 were deduced from the comparison of 1 H and 13 C NMR data, coupling constants and ROESY correlations with these of AGI-B4, 11 of which configuration was unambiguously established by an X-ray structure analysis. Xanthones are known to exhibit cytotoxic effects 6,9,12 . Compound 1 were tested for its cytotoxicity against five tumor cells line (NB4, A549, SHSY5Y, PC3 and MCF7) using a previously reported procedure 13 .…”

A New Cytotoxic Xanthone from Hypericum chinense

“…Strong absorption bands accounting for ν(OH) (3438 cm -1 ), ν(C=O) (1652 cm -1 ) and aromatic groups (1600, 1542, 1465 cm -1 ) could also be observed in its IR spectrum. The 1 Hand 13 C NMR spectrum (Table-1) displayed signals for all 16 carbons and 14 protons, including a xanthones skeleton 17 (C-1 -C-9, C-4a, C-8a -C-10a; H-2, H-5 -H-7), one methoxy group (δC 55.9 q, δH 3.80 s), a hydroxyethyl unit 11 [δC 34.3 t, 63.2 t; δH 2.50 t (7.2), 3.62 t (7.2)] and two phenolic hydroxy groups (δH 13.46 s and 13.14 s). The HMBC correlation (Fig.…”

“…The family Clusiaceae is a rich source of xanthones, which show various bioactivities 1,2 . These xanthones show various bioactivities, including, anti-hepatitis B virus 3 , anti-tobacco mosaic virus 4 , antibacterial 5,6 , antioxidant 7,8 , antiinflammatory 9 , tumor-promoting inhibition 10 and cytotoxicity 11,12 . The genus hypericum belonging to clusiaceae is distributed widely in temperate regions and has been used for traditional medicines in various parts of the world.…”

Xanthones and Cancer: from Natural Sources to Mechanisms of Action

“…Whole plant no [42] 8-O-β-D-Glucopyranosyl-1-hydroxy-2,3,5-trimethoxyxanthone Swertia mussotii Whole plant no [55] Amarellin A Gentianella amarela Aerial parts no [21] Amarellin B Gentianella amarela Aerial parts no [21] Amarellin C Gentianella amarela Aerial parts no [21] Amarellin D Gentianella amarela Aerial parts no [21] Amarellin E Gentianella amarella Aerial parts no [21] Amarellin F Gentianella amarela Aerial parts no [21] Angustin A Swertia angustifolia Aerial parts no [56] Angustin B Swertia angustifolia Aerial parts no [56] Banganxanthone C Garcinia polyantha Leaves yes [57] Beccarixanthone T Mesua beccariana Stem barks yes [58] Bellidifolin Swertia punicea Whole plant no [32] Bracteaxanthone III Garcinia bracteata Stem barks yes [24] Bracteaxanthone IV Garcinia bracteata Stem barks yes [24] Bracteaxanthone V Garcinia bracteata Stem barks yes [24] Bracteaxanthone VI Garcinia bracteata Stem barks yes [24] Bracteaxanthone VII Garcinia bracteata Leaves yes [59] Bracteaxanthone VIII Garcinia bracteata Leaves yes [59] Bracteaxanthone IX Garcinia bracteata Leaves yes [59] Bracteaxanthone X Garcinia bracteata Leaves yes [59] Bracteaxanthone XI Garcinia bracteata Leaves yes [59] Bracteaxanthone XII Garcinia bracteata Leaves yes [59] Bracthone A Garcinia bracteata Stems yes [60] Bracthone B Garcinia bracteata Stems yes [60] Butyraxanthone F Pentadesma butyracea…”