New World Trypanosomiasis

Miles, Michael A.

doi:10.1002/9780470688618.taw0184

Cited by 5 publications

(2 citation statements)

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“…The majority of patients survive the acute stage and enter the prolonged indeterminate stage without overt symptoms of disease, which lasts for life. However, thirty percent of patients develop chronic CD, which includes grave symptoms such as megaesophagus, megacolon, and chronic heart disease [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Trypanosoma cruziInfection and Host Lipid Metabolism

Miao

Ndao

2014

Mediators of Inflammation

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Trypanosoma cruzi is the causative agent of Chagas disease. Approximately 8 million people are thought to be affected worldwide. Several players in host lipid metabolism have been implicated in T. cruzi-host interactions in recent research, including macrophages, adipocytes, low density lipoprotein (LDL), low density lipoprotein receptor (LDLR), and high density lipoprotein (HDL). All of these factors are required to maintain host lipid homeostasis and are intricately connected via several metabolic pathways. We reviewed the interaction of T. cruzi with each of the relevant host components, in order to further understand the roles of host lipid metabolism in T. cruzi infection. This review sheds light on the potential impact of T. cruzi infection on the status of host lipid homeostasis.

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Section: Introductionmentioning

confidence: 99%

Trypanosoma cruziInfection and Host Lipid Metabolism

Miao

Ndao

2014

Mediators of Inflammation

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“…The hemocytes are the cells that circulate within the hemocele of insects and together with plasma and dissolved organic and inorganic molecules constitute the hemolymph, the analog of vertebrate’s blood [ 6 ]. Hemocytes perform several functions in the context of insect physiology, including humoral and cellular immune responses.…”

Section: Introductionmentioning

confidence: 99%

Morphological and Ultrastructural Characterization of Hemocytes in an Insect Model, the Hematophagous Dipetalogaster maxima (Hemiptera: Reduviidae)

Moyetta

Ramos

Leyria

et al. 2021

Insects

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Hemocytes, the cells present in the hemolymph of insects and other invertebrates, perform several physiological functions, including innate immunity. The current classification of hemocyte types is based mostly on morphological features; however, divergences have emerged among specialists in triatomines, the insect vectors of Chagas’ disease (Hemiptera: Reduviidae). Here, we have combined technical approaches in order to characterize the hemocytes from fifth instar nymphs of the triatomine Dipetalogaster maxima. Moreover, in this work we describe, for the first time, the ultrastructural features of D. maxima hemocytes. Using phase contrast microscopy of fresh preparations, five hemocyte populations were identified and further characterized by immunofluorescence, flow cytometry and transmission electron microscopy. The plasmatocytes and the granulocytes were the most abundant cell types, although prohemocytes, adipohemocytes and oenocytes were also found. This work sheds light on a controversial aspect of triatomine cell biology and physiology setting the basis for future in-depth studies directed to address hemocyte classification using non-microscopy-based markers.

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Some less well-documented pioneers

Cook

2008

Tropical Medicine

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New World Trypanosomiasis

Cited by 5 publications

References 100 publications

Trypanosoma cruziInfection and Host Lipid Metabolism

Trypanosoma cruziInfection and Host Lipid Metabolism

Morphological and Ultrastructural Characterization of Hemocytes in an Insect Model, the Hematophagous Dipetalogaster maxima (Hemiptera: Reduviidae)

Some less well-documented pioneers

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