New wine into old wineskins: PGC‐1α and NF‐κB in obesity and acute pancreatitis

Diakopoulos, Kalliope N.; Algül, Hana

doi:10.1002/path.5220

Cited by 3 publications

(1 citation statement)

References 10 publications

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“… 58 The reduction of PPARγ-coactivator 1 (PGC-1) in AP leads to a decrease in its binding affinity with p65 in NFkB, resulting in an augmentation of IL-6-mediated inflammatory damage. 59 Additionally, PPARγ is implicated in cell junctions. The activation of PPARγ by prostaglandin D2 metabolite in acute pancreatitis can attenuate the expression of intercellular adhesion molecule-1, thereby mitigating the severity of the condition.…”

Section: Discussionmentioning

confidence: 99%

Overexpression of Plakophilin2 Mitigates Capillary Leak Syndrome in Severe Acute Pancreatitis by Activating the p38/MAPK Signaling Pathway

Liu,

Xu,

et al. 2024

JIR

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Section: Discussionmentioning

confidence: 99%

Overexpression of Plakophilin2 Mitigates Capillary Leak Syndrome in Severe Acute Pancreatitis by Activating the p38/MAPK Signaling Pathway

Liu,

Xu,

et al. 2024

JIR

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Tamoxifen induced cardiac damage via the IL-6/p-STAT3/PGC-1α pathway

Meng,

Zhang,

Zhang

et al. 2023

International Immunopharmacology

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The protective effects of activating Sirt1/NF-κB pathway for neurological disorders

Song

Zhao

2021

Reviews in the Neurosciences

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Sirt1, a member of the sirtuins family, is a nicotinamide adenosine dinucleotide (NAD+)-dependent deacetylase. It can be involved in the regulation of several processes including inflammatory response, apoptosis, oxidative stress, energy metabolism, and autophagy by exerting deacetylation. Nuclear factor-κB (NF-κB), a crucial nuclear transcription factor with specific DNA binding sequences, exists in almost all cells and plays a vital role in several biological processes involving inflammatory response, immune response, and apoptosis. As the hub of multiple intracellular signaling pathways, the activity of NF-κB is regulated by multiple factors. Sirt1 can both directly deacetylate NF-κB and indirectly through other molecules to inhibit its activity. We would like to emphasize that Sirt1/NF-κB is a signaling pathway that is closely related to neuroinflammation. Many recent studies have demonstrated the neuroprotective effects of Sirt1/NF-κB signaling pathway activation applied to the treatment of neurological related diseases. In this review, we focus on new advances in the neuroprotective effects of the Sirt1/NF-κB pathway. First, we briefly review Sirt1 and NF-κB, two key molecules of cellular metabolism. Next, we discuss the connection between NF-κB and neuroinflammation. In addition, we explore how Sirt1 regulates NF-κB in nerve cells and relevant evidence. Finally, we analyze the therapeutic effects of the Sirt1/NF-κB pathway in several common neuroinflammation-related diseases.

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New wine into old wineskins: PGC‐1α and NF‐κB in obesity and acute pancreatitis

Cited by 3 publications

References 10 publications

Overexpression of Plakophilin2 Mitigates Capillary Leak Syndrome in Severe Acute Pancreatitis by Activating the p38/MAPK Signaling Pathway

Overexpression of Plakophilin2 Mitigates Capillary Leak Syndrome in Severe Acute Pancreatitis by Activating the p38/MAPK Signaling Pathway

Tamoxifen induced cardiac damage via the IL-6/p-STAT3/PGC-1α pathway

The protective effects of activating Sirt1/NF-κB pathway for neurological disorders

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