New way to obtain the poly(L-lactide-co-D,L-lactide) blend filled with nanohydroxyapatite as biomaterial for 3D-printed bone-reconstruction implants

Targońska, Sara; Dobrzyńska‐Mizera, Monika; Wujczyk, Marta; Soroczynska, Justyna Rewak-; Knitter, Monika; Dopierała, Katarzyna; Andrzejewski, Jacek; Wiglusz, Rafał J.

doi:10.1016/j.eurpolymj.2022.110997

Cited by 13 publications

(25 citation statements)

References 45 publications

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“…Further studies will focus on improving the adhesion of HAP nanoparticles to PLA and mixing HAP within an organic template by using amphiphilic biomolecules to create the coating that will tune the biological response of the host body to polymer bone implants. Furthermore, deposition of the HAP particles on the PLA surface together with the loading polymer with HAP, as shown in our previous work, might be a promising strategy to improve early-stage and long-term osteointegration.…”

Section: Discussionmentioning

confidence: 77%

“…The recent advancements in tissue engineering, especially in the field of bone regeneration, force further improvements in material engineering in order to fulfill patients’ needs. For these purposes, various types of bioresorbable polymers and copolymers of lactic acid, ethane-1,2-diol (ethyl glycol), or chitosan (poly( d )-glucosamine) are commonly used. − Polylactides (PLAs) are notably interesting due to their bioresorbability while maintaining the appropriate mechanical strength and easy processing via basic industrial methods. Their physicochemical and mechanical properties may be further tailored by bulk modification with bioactive inorganic fillers, which alter degradation kinetics, resorption, and mechanical properties. , However, apart from bulk characteristics, it is essential to consider PLA surface properties in order to enhance the interactions with cells.…”

Section: Introductionmentioning

confidence: 99%

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Surface Functionalization of Poly(lactic acid) via Deposition of Hydroxyapatite Monolayers for Biomedical Applications

Dopierała,

Knitter,

Dobrzyńska-Mizera

et al. 2023

Langmuir

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The surface modification of poly(lactic acid) (PLA) using hydroxyapatite (HAP) particles via Langmuir−Blodgett (LB) and Langmuir− Schaefer (LS) approaches has been reported. The HAP monolayer was characterized at the air/water interface and deposited on three-dimensional (3D) printed poly(lactic acid). The deposition of HAP particles using the LS approach led to a larger surface coverage in comparison to the LB method, which produces a less uniform coating because of the aggregation of the particles. After the transfer of HAP on the PLA surface, the wettability values remained within the desired range. The presence of HAP on the surface of the polymer altered the topography and roughness in the nanoscale, as evidenced by the atomic force microscopy (AFM) images. This effect can be beneficial for the osteointegration of polymeric implants at an early stage, as well as for the reduction of the adherence of the microbial biofilm. Overall, the results suggest that the LS technique could be a promising approach for surface modification of PLA by hydroxyapatite with respective advantages in the biomedical field.

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Section: Discussionmentioning

confidence: 77%

Section: Introductionmentioning

confidence: 99%

Surface Functionalization of Poly(lactic acid) via Deposition of Hydroxyapatite Monolayers for Biomedical Applications

Dopierała,

Knitter,

Dobrzyńska-Mizera

et al. 2023

Langmuir

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“…The solvent was used within the film preparation step and despite of an application of post‐processing treatment at 70°C for 4 h, it was not fully removed (Table 3). The second stage of weight loss comes from PLA degradation 42,45 . The thermal degradation ( T Onset ) of neat PLA (S‐neat) started at 331°C and completed at about 380°C.…”

Section: Resultsmentioning

confidence: 99%

“…Samples of 6.5 ± 0.5 mg were used. The information extracted from TGA data and its first derivative (DTG) were onset ( T Onset ) and end ( T Endset ) temperatures, as well as peak temperature ( T max ) obtained from DTG 40,42 …”

Section: Methodsmentioning

confidence: 99%

“…The second stage of weight loss comes from PLA degradation. 42,45 The thermal degradation (T Onset ) of neat PLA (S-neat) started at 331 C and completed at about 380 C. The maximum degradation rate (T max ) took place at 358 C. According to Table 3, the surface functionalization of PLA did not influence PLA thermal stability. However, changes are visible in the first stage of decomposition, which is solvent evaporation.…”

Section: Thermogravimetric Analysismentioning

confidence: 99%

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Thermal and mechanical properties of aminolyzed‐poly(lactic acid) with amine‐terminated dendritic polymer: Surface and bulk functionalization

Shakoorjavan,

Dobrzyńska‐Mizera,

Akbari

et al. 2024

Polymer Engineering & Sci

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This study details the effect of surface and bulk functionalization of poly(lactic acid) (PLA) with an amine‐terminated dendritic polymer, poly(amidoamine) (PAMAM), on the thermal and mechanical properties of PLA‐based formulations. Fourier‐transform infrared spectroscopy (FTIR) confirmed the presence of –NH2 groups derived from PAMAM, through emerging new peaks at around 1650 cm−1 associated with –NH bending vibration and separate double peak between 3705 and 3110 cm−1 associated with stretching vibration of –NH amide groups, in both surface and bulk functionalized PLA samples. Differential scanning calorimetry (DSC) measurements revealed a lowering of cold‐crystallization temperature (Tcc) for both surface and bulk functionalized PLA, suggesting that PAMAM served as a nucleating agent. According to thermogravimetric results (TGA), bulk treatment deteriorated the thermal stability of the polymer; while surface modification did not influence the decomposition pathway. Mechanical test results revealed that PAMAM greatly influenced the stiffens and ductility of the composites, with more pronounced changes for higher aminolysis rates. Therefore, the 3‐h PAMAM surface functionalization of PLA limits its affinity to solvents' content and enhances crystallization upon permissible deterioration in mechanical properties.Highlights Development of aminolyzed‐PLA by surface and bulk modification with PAMAM dendritic polymer. PAMAM as a nucleating agent for PLA. Surface modification as the favorable condition to introduce NH2 groups to PLA.

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Preparation and Evaluation of the Properties of FDM Printed Materials Made from Waste-Origin Polymers

Cudnik,

Andrzejewski

2024

Lecture Notes in Mechanical Engineering

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New way to obtain the poly(L-lactide-co-D,L-lactide) blend filled with nanohydroxyapatite as biomaterial for 3D-printed bone-reconstruction implants

Cited by 13 publications

References 45 publications

Surface Functionalization of Poly(lactic acid) via Deposition of Hydroxyapatite Monolayers for Biomedical Applications

Surface Functionalization of Poly(lactic acid) via Deposition of Hydroxyapatite Monolayers for Biomedical Applications

Thermal and mechanical properties of aminolyzed‐poly(lactic acid) with amine‐terminated dendritic polymer: Surface and bulk functionalization

Preparation and Evaluation of the Properties of FDM Printed Materials Made from Waste-Origin Polymers

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