New water-soluble forms of α-tocopherol: preparation and study of antioxidant activity in vitro

Kurmaz, S. V.; Фадеева, Н. В.; Skripets, Julia A.; Komendant, R. I.; Ignatiev, Vladislav M.; Emel’yanova, N. S.; Soldatova, Yuliya V.; Faingold, I. I.; Poletaeva, D. A.; Kotelnikova, R. A.

doi:10.1016/j.mencom.2022.01.038

Cited by 5 publications

(4 citation statements)

References 18 publications

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“…When the concentrations of α -tocopherol were between 50–80 μg/mL, the scavenging capacities of lysozyme- α -tocopherol mixtures were similar to those of lysozyme alone, because the encapsulation by lysozyme shielded α -tocopherol from the attack of ABTS· + in the aqueous solution. The masking effect was previously reported for the encapsulation of α -tocopherol by zein and N -vinylpyrrolidone/triethylene glycol dimethacrylate [ 2 , 22 ]. When the concentrations of α -tocopherol were 30 and 40 μg/mL, the scavenging capacities of lysozyme- α -tocopherol mixtures were less than their individual sum, and their difference was greater than the scavenging capacity of α -tocopherol.…”

Section: Resultsmentioning

confidence: 77%

Encapsulation of Folic Acid and α-Tocopherol in Lysozyme Particles and Their Bioaccessibility in the Presence of DNA

Gao²,

Cheng

et al. 2023

Antioxidants

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Protein particles have been reported as the potential carriers for the co-encapsulation of bioactive components. In this study, lysozyme, a basic protein, was used to simultaneously encapsulate folic acid and α-tocopherol at pH 4.0. The encapsulation efficiency and loading capacity of folic acid or α-tocopherol increased with its respective concentration. Folic acid had no influence on the encapsulation of α-tocopherol. However, the encapsulation of folic acid was improved by α-tocopherol below 40 μg/mL but reduced by α-tocopherol at higher concentrations. The encapsulation by lysozyme shielded folic acid, α-tocopherol, or both partially from the attack of 2,2′-azino-bis-3-ethylbenzthiazoline-6-sulphonic acid (ABTS) radical cation. No masking effect of lysozyme encapsulation on α-tocopherol was found in DPPH antioxidant activity assay. Furthermore, the DNA coating was used to improve the dispersion of lysozyme with folic acid and α-tocopherol. The lysozyme/DNA particles with folic acid and α-tocopherol showed a homogenous size distribution of 180–220 nm with ζ-potential values between −33 and −36 mV. The release and bioaccessibility of folic acid in lysozyme/DNA with α-tocopherol were similar to that of folic acid alone, while the release of α-tocopherol was delayed and its bioaccessibility was improved by encapsulation in lysozyme/DNA with folic acid. The data gathered here would provide guidance for the use of lysozyme-based co-encapsulating carriers in the development of functional foods.

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Section: Resultsmentioning

confidence: 77%

Encapsulation of Folic Acid and α-Tocopherol in Lysozyme Particles and Their Bioaccessibility in the Presence of DNA

Gao²,

Cheng

et al. 2023

Antioxidants

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“…TP is soluble in alcohol and its absorption spectra in IPA are shown in Figure S2 (Supplementary Materials) . The absorption dependence of the band at 290 nm wavelengths on TP concentration was linear and obeyed the Beer–Lambert law [ 59 ]; thus, there were not any intermolecular interactions between the components of solution. However, the hydroxyl group of TP can partake in the formation of intermolecular hydrogen bonds [ 60 ].…”

Section: Resultsmentioning

confidence: 99%

“…The effective binding constant K ef of TP with CPL1 and CPL2 was equal to 0.72 × 10 4 and 1.35 × 10 4 M −1 at 22 °C, resp. Thus, both copolymers bonded to TP through intermolecular interactions, primarily the hydrogen bonding which is formed among the OH group of TP and the donor groups of the copolymers [ 59 ]. It is expected that hydrophobic interactions between the alkyl substituent of TP and alkyl substituents of HMA occur when guest molecules are localized in the low-polarity core of the CPL2 nanoparticles.…”

Section: Resultsmentioning

confidence: 99%

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Design and Investigation of New Water-Soluble Forms of α-Tocopherol with Antioxidant and Antiglycation Activity Using Amphiphilic Copolymers of N-Vinylpyrrolidone

et al. 2023

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Water-soluble forms of α-tocopherol (TP) as an effective antioxidant were obtained by encapsulating it into nanoparticles (NPs) of amphiphilic copolymers of N-vinylpyrrolidone with triethylene glycol dimethacrylate (CPL1-TP) and N-vinylpyrrolidone with hexyl methacrylate and triethylene glycol dimethacrylate (CPL2-TP) synthesized by radical copolymerization in toluene. The hydrodynamic radii of NPs loaded with TP (3.7 wt% per copolymers) were typically ca. 50 or 80 nm depending on copolymer composition, media, and temperature. Characterization of NPs was accomplished by transmission electron microscopy (TEM), IR-, and 1H NMR spectroscopy. Quantum chemical modeling showed that TP molecules are capable to form hydrogen bonds with donor groups of the copolymer units. High antioxidant activity of both obtained forms of TP has been found by the thiobarbituric acid reactive species and chemiluminescence assays. CPL1-TP and CPL2-TP effectively inhibited the process of spontaneous lipid peroxidation as well as α-tocopherol itself. The IC50 values of luminol chemiluminescence inhibition were determined. Antiglycation activity against vesperlysine and pentosidine-like AGEs of TP water-soluble forms was shown. The developed NPs of TP are promising as materials with antioxidant and antiglycation activity and can be used in various biomedical applications.

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Doxorubicin compositions with biocompatible terpolymer of N-vinylpyrrolidone, methacrylic acid and triethylene glycol dimethacrylate

Kurmaz

Ivanova

Emel’yanova

et al. 2023

Mendeleev Communications

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New water-soluble forms of α-tocopherol: preparation and study of antioxidant activity in vitro

Cited by 5 publications

References 18 publications

Encapsulation of Folic Acid and α-Tocopherol in Lysozyme Particles and Their Bioaccessibility in the Presence of DNA

Encapsulation of Folic Acid and α-Tocopherol in Lysozyme Particles and Their Bioaccessibility in the Presence of DNA

Design and Investigation of New Water-Soluble Forms of α-Tocopherol with Antioxidant and Antiglycation Activity Using Amphiphilic Copolymers of N-Vinylpyrrolidone

Doxorubicin compositions with biocompatible terpolymer of N-vinylpyrrolidone, methacrylic acid and triethylene glycol dimethacrylate

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