New views on the complex interplay between degeneration and autoimmunity in multiple sclerosis
Peter K. Stys,
Shigeki Tsutsui,
Arie R. Gafson
et al.
Abstract:Multiple sclerosis (MS) is a frequently disabling neurological disorder characterized by symptoms, clinical signs and imaging abnormalities that typically fluctuate over time, affecting any level of the CNS. Prominent lymphocytic inflammation, many genetic susceptibility variants involving immune pathways, as well as potent responses of the neuroinflammatory component to immunomodulating drugs, have led to the natural conclusion that this disease is driven by a primary autoimmune process. In this Hypothesis an… Show more
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