New view of the eye

Zacharria, Mark; Lamory, B.; Château, Nicolas

doi:10.1038/nphoton.2010.298

Cited by 13 publications

(9 citation statements)

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“…The adaptive optics fundus camera designed for clinical research (rtx1, Imagine Eyes, France) is a compact system that can produce 4° × 4° high resolution images of the retina, especially the cone photoreceptor mosaic [10, 11]. Its adaptive optics comprise a magnetic membrane deformable mirror of 52 actuators, a Shack-Hartmann wavefront sensor with 32 × 40 lenslets (mirao 52-e, HASO 32-eye, both from Imagine Eyes, France) and a superluminescent diode of 750 nm central wavelength that served the sensor.…”

Section: Methodsmentioning

confidence: 99%

Adaptive optics with pupil tracking for high resolution retinal imaging

Sahin

Lamory

Lévecq

et al. 2012

Biomed. Opt. Express

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Adaptive optics, when integrated into retinal imaging systems, compensates for rapidly changing ocular aberrations in real time and results in improved high resolution images that reveal the photoreceptor mosaic. Imaging the retina at high resolution has numerous potential medical applications, and yet for the development of commercial products that can be used in the clinic, the complexity and high cost of the present research systems have to be addressed. We present a new method to control the deformable mirror in real time based on pupil tracking measurements which uses the default camera for the alignment of the eye in the retinal imaging system and requires no extra cost or hardware. We also present the first experiments done with a compact adaptive optics flood illumination fundus camera where it was possible to compensate for the higher order aberrations of a moving model eye and in vivo in real time based on pupil tracking measurements, without the real time contribution of a wavefront sensor. As an outcome of this research, we showed that pupil tracking can be effectively used as a low cost and practical adaptive optics tool for high resolution retinal imaging because eye movements constitute an important part of the ocular wavefront dynamics.

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Section: Methodsmentioning

confidence: 99%

Adaptive optics with pupil tracking for high resolution retinal imaging

Sahin

Lamory

Lévecq

et al. 2012

Biomed. Opt. Express

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“…43 A few years later, Roorda and coworkers 58 reported the use of AO in scanning laser ophthalmoscopy (SLO), which gave further insight into the visualization and analysis of retinal structures. Now, almost two decades later, AO SLO devices are still custom made; however, AO flood illumination ophthalmoscopy (FIO) is available in a commercial device 70 , and more AO retinal research data are being gathered.…”

Section: Introductionmentioning

confidence: 99%

Adaptive optics ophthalmoscopy: a systematic review of vascular biomarkers

Bakker

Dikland

Bakel

et al. 2022

Survey of Ophthalmology

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parietal thickness (PT), wall cross-sectional area (WCSA), and wall-to-lumen ratio (WLR). The applicability of AO vascular biomarkers has been mostly explored in systemic hypertension using AO FIO and in diabetes using AO SLO. The result of the meta-analysis for hypertensive patients showed that WLR, PT, and ID were significantly different when compared to healthy controls, while WCSA was not (P < 0.001, P = 0.002, P < 0.001, and P = 0.070, respectively). The presented review shows that, although a substantial number of retinal vascular biomarkers have been explored in AO en face imaging, further clinical research and standardization of procedures is needed to validate such biomarkers for the longitudinal monitoring of arterial hypertension and other diseases.

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“…A full technical description of the rtx1 is available in Zacharria et al. 18 A defocus of +0.50 diopters (corrected by a modified Badal assembly incorporated in the commercial device) was used for NHP imaging. Nonhuman primates were anesthetized during data acquisition because fixation could not be maintained otherwise.…”

Section: Methodsmentioning

confidence: 99%