New Variants of Porcine Epidemic Diarrhea Virus, China, 2011

Abstract

In 2011, porcine epidemic diarrhea virus (PEDV) infection rates rose substantially in vaccinated swine herds. To determine the distribution profile of PEDV outbreak strains, we sequenced the full-length spike gene from samples from 9 farms where animals exhibited severe diarrhea and mortality rates were high. Three new PEDV variants were identified.

Characterization of Porcine Epidemic Diarrhea Virus Isolate US/Iowa/18984/2013 Infection in 1-Day-Old Cesarean-Derived Colostrum-Deprived Piglets

“…Furthermore, US/Iowa/18984 of 2013 induces similar clinical signs and severity of disease as reported with recent Chinese PEDV strains, which have exhibited enhanced disease in endemic regions with increased morbidity and mortality. 10 Historical observations along with the results from this study imply virulence differences among PEDV isolates, similar to what has been reported for TGEV. 8 PEDV has been described as less virulent than TGEV 9,16 ; however, studies reporting reduced morbidity and mortality were conducted prior to the identification of the highly virulent Chinese PEDV strains documented in 2010.…”

“…8 PEDV has been described as less virulent than TGEV 9,16 ; however, studies reporting reduced morbidity and mortality were conducted prior to the identification of the highly virulent Chinese PEDV strains documented in 2010. 10 Our results suggest similarities between TGEV and PEDV in terms of clinical disease and microscopic lesions. Specifically, diarrhea was reported earlier (18 hpi) in the current study compared to what was observed in the study conducted with 3 different TGEV isolates.…”

Porcine epidemic diarrhea virus: current insights

“…10,11,67 Although many swine herds had been vaccinated with CV777 strain-based inactivated vaccines, the outbreaks caused moderate-to-high mortality in suckling piglets. 67 The results of many studies based on sequencing and phylogenetic analyses showed that these PEDV isolates with high virulence circulating in the People's Republic of China were new variants and differed genetically from the prototype CV777 strain. 11,59,[67][68][69][70][71][72][73][74][75][76][77][78] Now, PED became endemic; however, it remains the most devastating enteric disease leading to serious losses in the People's Republic of China.…”

Optimization of expression and purification of recombinant S1 domain of the porcine epidemic diarrhea virus spike (PEDV- S1) protein inEscherichia coli

“…The disease was initially recognized in England in 1971, but the causative agent of this disease, PED virus (PEDV), was identified in 1978 [3]. PED epidemics were first reported in Asia in 1982, and since then, PED has continued to threaten swine health, causing substantial economic losses in the Asian swine industry [4][5][6]. In 2013, PED outbreaks suddenly occurred in the United States and have swept through the pork industry across the country, raising concerns about control measures for PED prevention [7,8].…”