New Values of the Required Hydrophilic-Lipophilic Balance for Oil in Water Emulsions of Solid Fatty Acids and Alcohols Obtained from Solubility Parameter and Dielectric Constant Values

Pasquali, Ricardo C.; Bregni, Carlos; Taurozzi, Melina P.

doi:10.1080/01932690802540517

Cited by 12 publications

(4 citation statements)

References 2 publications

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“…For Compritol 888 ATO, a value of 18.89 MPa 1/2 was proposed,26 and a value of 15.83 MPa 1/2 was found for stearic acid 27. As the solubility of a drug in a given solvent occurs, when Δ δ = δ solvent − δ solute < 10, it can be concluded that solubility of the three diclofenac forms in the Compritol‐based mixtures is expected.…”

Section: Resultsmentioning

confidence: 99%

Hepatitis B virus X protein sensitizes cells to starvation-induced autophagy via up-regulation of beclin 1 expression

et al. 2008

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Section: Resultsmentioning

confidence: 99%

Hepatitis B virus X protein sensitizes cells to starvation-induced autophagy via up-regulation of beclin 1 expression

et al. 2008

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“…The rHLB value of the lipid matrix of the coenzyme Q10 NLCs was calculated based on the rHLB value of blended myristic acidoleic acid, myristic acid-isopropyl myristate, and myristic acid-isopropyl palmitate. The rHLB value of myristic acid is not available (Pasquali et al, 2009), therefore, it was assuming the same with rHLB of stearic acids (15), which have almost the same length hydrocarbon chains. The rHLB value of oleic acid is 11, whereas isopropyl myristate and isopropyl palmitate have the same rHLB values, i.e., 11.5.…”

Section: Selection Of the Coenzyme Q10 Nlc Formulasmentioning

confidence: 99%

Development, characterization in vitro and in silico of coenzyme Q10 loaded myristic acid with different liquid lipids nanostructured lipid carriers

Aryani¹,

Siswandono²,

Soeratri³

et al. 2021

J Pharm Pharmacogn Res

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Context: Nanostructured lipid carriers can enhance skin penetration of active substances. Coenzyme Q10 is a lipophilic antioxidant, that has poor skin penetration. This limitation is overcome by nanostructured lipid carriers. Aims: To developed coenzyme Q10 nanostructured lipid carriers using myristic acid with various liquid lipids as lipid matrix by in vitro studies and in silico approach for explaining the interaction of coenzyme Q10-lipid at the molecular level. Methods: The coenzyme Q10 nanostructured lipid carriers were prepared using myristic acid as solid lipid with oleic acid, isopropyl myristate, and isopropyl palmitate as liquid lipids using the high shear homogenization method. Then, they were evaluated in physicochemical characteristics by dynamic light scattering, differential scanning calorimetry, Fourier transforms infrared, scanning electron microscopy, spectrophotometry ultraviolet-visible, and pH meter. Furthermore, the in silico studies were conducted using AutoDock 4.2. Results: The coenzyme Q10 nanostructured lipid carriers using myristic acid-oleic acid, myristic acid-isopropyl myristate, and myristic acid-isopropyl palmitate as lipid matrix had the mean particle size, polydispersity index, entrapment efficiency, drug loading, and pH value were less than 300 nm, less than 0.3, more than 80%, about 10%, and about 5.0, respectively. Moreover, molecular docking of coenzyme Q10 and lipid showed hydrogen and hydrophobic bonds. These results supported differential scanning calorimetry and Fourier transforms infrared results. Conclusions: The coenzyme Q10 nanostructured lipid carriers were successfully prepared using myristic acid-oleic acid, myristic acid-isopropyl myristate, and myristic acid-isopropyl palmitate as lipid matrix as well as in silico study could be used for explaining of coenzyme Q10-lipid interaction.

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“…Hydrophile-Lipophile Balance (HLB) value, proposed by Griffin, is one of the indexes in selecting non-ionic surfactants [10] [11]. It is defined as a value to indicate the affinity of a surfactant for water and oil.…”

Section: Discussionmentioning

confidence: 99%

Lamiaceae Peppermint Oil with Surfactant Showing Equal Antifungal Activity against <i>Candida albicans</i> to Rosemary Chemotype CINEOL

Matsuzaki¹,

Kakinoki²,

Nakamura³

et al. 2014

AID

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Oral candidiasis causes pain in oral cavity or tongue. Antifungal drugs are commonly used for the treatment of candidiasis, however, there could be several problems such as side effects, drug resistance, or contraindication to concomitant use with drugs already taken. The development of substituting antimicrobial agents, which could be used internally or as gargling agents, is expected. Some essential oils have been known for the activities against microbes. We focused on the three chemotype essential oils from rosemary and five essential oils from Lamiaceae plants including rosemary, and examined their antifungal activity against Candida albicans by broth microdilution method. The activity with or without addition of Tween 80 or Tween 20 was statistically analyzed. Minimal inhibitory concentration (MIC) values of the essential oils were significantly decreased when either of the two surfactants was added. Among the tested oils, only CAMPHOR, a rosemary chemotype, showed a significantly lower MIC with addition of Tween 20 than Tween 80. It is inferred that the antifungal activity of essential oils is influenced by the type of surfactants. Some of the essential oils showed the same values of MIC and the minimal fungicidal concentration (MFC) when surfactant was added. Peppermint showed the same MICs and MFCs in most cases, and its low MFC indicated potent fungicidal activity against C. albicans, as observed in CINEOL. We will * Corresponding author. Y. Matsuzaki et al. 59discuss peppermint oil as one of the potential candidates for antifungal agents against C. albicans.

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New Values of the Required Hydrophilic-Lipophilic Balance for Oil in Water Emulsions of Solid Fatty Acids and Alcohols Obtained from Solubility Parameter and Dielectric Constant Values

Cited by 12 publications

References 2 publications

Hepatitis B virus X protein sensitizes cells to starvation-induced autophagy via up-regulation of beclin 1 expression

Hepatitis B virus X protein sensitizes cells to starvation-induced autophagy via up-regulation of beclin 1 expression

Development, characterization in vitro and in silico of coenzyme Q10 loaded myristic acid with different liquid lipids nanostructured lipid carriers

Lamiaceae Peppermint Oil with Surfactant Showing Equal Antifungal Activity against <i>Candida albicans</i> to Rosemary Chemotype CINEOL

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New Values of the Required Hydrophilic-Lipophilic Balance for Oil in Water Emulsions of Solid Fatty Acids and Alcohols Obtained from Solubility Parameter and Dielectric Constant Values

Cited by 12 publications

References 2 publications

Hepatitis B virus X protein sensitizes cells to starvation-induced autophagy via up-regulation of beclin 1 expression

Hepatitis B virus X protein sensitizes cells to starvation-induced autophagy via up-regulation of beclin 1 expression

Development, characterization in vitro and in silico of coenzyme Q10 loaded myristic acid with different liquid lipids nanostructured lipid carriers

Lamiaceae Peppermint Oil with Surfactant Showing Equal Antifungal Activity against &lt;i&gt;Candida albicans&lt;/i&gt; to Rosemary Chemotype CINEOL

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Lamiaceae Peppermint Oil with Surfactant Showing Equal Antifungal Activity against <i>Candida albicans</i> to Rosemary Chemotype CINEOL