2018
DOI: 10.22159/ijpps.2018v10i12.26650
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New Validated Method Development for the Estimation of Sulfamethoxazole and Trimethoprim in Bulk Form by Visible Spectroscopy

Abstract: Objective: To develop three novel, sensitive, simple validated visible spectrophotometric methods for the quantitative estimation of sulfamethoxazole (SMZ) and trimethoprim (TMP) in bulk form.Methods: Methods were based on coupling the diazotized aromatic primary amino group of the studied drugs with o-phenylenediamine (OPD) in an acidic medium. The first two methods have been proposed for estimation of SMZ and rest for TMP. The resulting products were measured by spectrophotometric (method I, II and III) tool… Show more

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Cited by 2 publications
(2 citation statements)
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“…To document the in vitro release performance of each drug, dissolution samples were taken at 15-, 20-, 30-, 45-, and 60min using fiberglass filters (n=12). Several analytical methods have been published to quantify SMZ and TMP [10][11][12] however, the amount of each dissolved drug was determined by a spectrophotometric derivative method previously developed by our research group [13]. Standard calibration curves in each dissolution medium were prepared (SMZ: 250-350 µg/ml and TMP: 10-50 µg/ml).…”
Section: In Vitro Release Studiesmentioning
confidence: 99%
“…To document the in vitro release performance of each drug, dissolution samples were taken at 15-, 20-, 30-, 45-, and 60min using fiberglass filters (n=12). Several analytical methods have been published to quantify SMZ and TMP [10][11][12] however, the amount of each dissolved drug was determined by a spectrophotometric derivative method previously developed by our research group [13]. Standard calibration curves in each dissolution medium were prepared (SMZ: 250-350 µg/ml and TMP: 10-50 µg/ml).…”
Section: In Vitro Release Studiesmentioning
confidence: 99%
“…The repeatability (precision of the instrument) was checked by measuring the absorbance of six determinations of 10 μg/ml solution, and percentage relative standard deviation (%RSD) was calculated [7,8].…”
Section: Repeatabilitymentioning
confidence: 99%