New Understanding of Age-Related Macular Degeneration Through Quantitative Autofluorescence

Rjh, Smith

doi:10.1001/jamaophthalmol.2016.1466

Cited by 9 publications

(10 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…10 Recently, quantitative autofluorescence has shown that lipofuscin levels are reduced in progressive age-related macular degeneration (AMD), rather than increasing, which is contradictory to the lipofuscin toxicity theory. 11,12 Gomes et al 13 reported that in the majority of patients with Stargardt disease, the eye changes determined using spectral-domain optical coherence tomography correlated well with changes on fundus autofluorescence. However, some patients (3 out of 11) demonstrated photoreceptor abnormalities without equivalent abnormality on fundus autofluorescence, suggesting that structural integrity of the photoreceptors may be affected earlier than changes in the RPE.…”

mentioning

confidence: 99%

Omega-3 Fatty Acids Supplementation: Therapeutic Potential in a Mouse Model of Stargardt Disease

Prokopiou¹,

Kolovos²,

Kalogerou³

et al. 2018

Invest. Ophthalmol. Vis. Sci.

View full text Add to dashboard Cite

show abstract

mentioning

confidence: 99%

Omega-3 Fatty Acids Supplementation: Therapeutic Potential in a Mouse Model of Stargardt Disease

Prokopiou¹,

Kolovos²,

Kalogerou³

et al. 2018

Invest. Ophthalmol. Vis. Sci.

View full text Add to dashboard Cite

show abstract

“…These findings imply that there may not be a simple relationship between lipofuscin accumulation in RPE and the AF signal being captured, and brings into question the veracity of strategies aiming to measure the AF signal as a useful measure in trials aiming to reduce lipofuscin accumulation as a treatment strategy. 8,18,19 One possible explanation for the lack of a significant difference between AMD and healthy eyes is that other retinal fluorophores in the RPE of the AMD eyes may interfere with the ability to visualize an increase in lipofuscin accumulation on qAF imaging. 1 In addition, the Delori grid used to obtain the qAF measurements in this study may be sampling a region that does not capture the lipofuscin accumulation in the macular region where this occurs, because it only obtains qAF measurements at an eccentricity between 9°to 11°f rom the fovea.…”

Section: Discussionmentioning

confidence: 99%

Natural History of Quantitative Autofluorescence in Intermediate Age-Related Macular Degeneration

Emde

Guymer

Pfau

et al. 2021

Retina

View full text Add to dashboard Cite

Purpose: To investigate differences in quantitative autofluorescence (qAF) imaging measurements between eyes with and without large drusen, and whether qAF measurements change over time in the eyes with large drusen.Methods: Eighty-five eyes from participants with bilateral large drusen and 51 eyes from healthy participants underwent qAF imaging at least once, and the age-related macular degeneration participants were reviewed 6-monthly. Normalized grey values at 9°to 11°e ccentricity from the fovea were averaged to provide a summary measure of qAF values (termed qAF 8 ).Results: In a multivariable model, qAF 8 measurements were not significantly different between age-related macular degeneration eyes with large drusen and healthy eyes (P = 0.130), and qAF 8 measurements showed a decline over time in the age-related macular degeneration eyes (P = 0.013).Conclusion: These findings add to the body of evidence that qAF levels are not increased in eyes with large drusen compared with healthy eyes, and qAF levels show a significant decline over time in the age-related macular degeneration eyes. These findings highlight how the relationship between qAF levels and retinal pigment epithelium health does not seem to be straightforward. Further investigation is required to better understand this relationship, especially if qAF levels are to be used as an outcome measure in intervention trials.

show abstract

“…The differences were statistically significant. It showed that the improvement of blood supply to the macular area could alleviate edema of the macular center and decrease CFT value; increased blood supply to the macular area could also directly optimize retinal function in order to improve visual acuity (23). …”

Section: Discussionmentioning

confidence: 99%

Effect of anti-VEGF drugs combined with photodynamic therapy in the treatment of age-related macular degeneration

Dong

Wan

Yan

et al. 2016

Experimental and Therapeutic Medicine

View full text Add to dashboard Cite

We analyzed the effects of anti-vascular endothelial growth factor (VEGF) drugs combined with photodynamic therapy (PDT) in the treatment of age-related macular degeneration (AMD). Ninety-six cases (192 eyes) of AMD were included in this study and randomly divided into the observation group and control group (n=48 cases per group). The control group was administered the treatment of Lucentis intravitreal injection alone and the observation group was administered Lucentis combined with PDT. The therapeutic effects were compared. The best corrected visual acuity of patients in the two groups increased gradually after treatment. Patients in the observation group had a significantly higher visual acuity when compared to the control group 1 and 6 months post-operation. The differences were statistically significant (P<0.05). The proportion of patients with vision improvement in the observation group was higher than that in the control group from 1 to 6 months; differences were statistically significant (P<0.05). Through detection by color Doppler ultrasound within 6 months after treatment, we observed that the peak systolic velocity and arterial end diastolic velocity of retrobulbar optic nerve bitemporal PCA of the observation group were higher than those of the control group. The values of arterial resistance index and pulsatility index of the observation group were lower than those of control group. The differences were statistically significant (P<0.05). Six months after treatment, the value of central foveal thickness of the observation group was lower than that of the control group, the value of mean sensitivity of visual field parameter 10° and 4° was higher in the observation group than in the control group, and the absolute value of mean defects in the observation group were lower than that of the control group. In summary, the differences were statistically significant (P<0.05). Anti-VEGF drugs combined with PDT can optimize the overall vision of patients with AMD, improve hemodynamic parameters and reduce visual field defects.

show abstract

New Understanding of Age-Related Macular Degeneration Through Quantitative Autofluorescence

Cited by 9 publications

References 7 publications

Omega-3 Fatty Acids Supplementation: Therapeutic Potential in a Mouse Model of Stargardt Disease

Omega-3 Fatty Acids Supplementation: Therapeutic Potential in a Mouse Model of Stargardt Disease

Natural History of Quantitative Autofluorescence in Intermediate Age-Related Macular Degeneration

Effect of anti-VEGF drugs combined with photodynamic therapy in the treatment of age-related macular degeneration

Contact Info

Product

Resources

About