“…These compounds differ from 1,2,4-butanetriol backbone-based lipids found in some eukaryotes. [17,18] Although the exact stereochemistry of the butanetriol backbone remains to be determined, the iso-BDGTs containing isoprenoidal tetraether moieties are structurally related analogues of archaeal iso-GDGTs, strongly suggesting that they are biosynthetic products of certain members of Archaea. We did not detect pentanetriol as an ether cleavage product, likely due to poor recovery combined with the low concentration of iso-PDGTs in the sample from White Oak River Estuary used for this experiment.…”