New Tubular Bioabsorbable Knitted Airway Stent: Feasibility Assessment for Delivery and Deployment in a Dog Model

Saito, Yukihito; Minami, Ken-ichiro; Kaneda, Hidehiro; Okada, Takayuki; Maniwa, Tomohiro; Araki, Yoshinori; Imamura, Hiroji; Yamada, Hirokazu; Igaki, Keiji; Tamai, Hideo

doi:10.1016/s0003-4975(03)01408-5

Cited by 32 publications

(34 citation statements)

References 9 publications

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“…Knitting is a technique that is used to create scaffolds and prostheses, such as stents for the trachea [19] and bile duct [20], scaffolds for the anterior cruciate ligament [21] and the widely used Dacron cardiovascular prostheses [22]. An advantage of knitting are the complex geometries that can be produced, e.g., branched prostheses used for aortic arch replacements [23].…”

Section: Introductionmentioning

confidence: 99%

Electrospinning versus knitting: two scaffolds for tissue engineering of the aortic valve

Lieshout¹,

Vaz²,

Rutten³

et al. 2006

Journal of Biomaterials Science, Polymer Edition

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Abstract-Two types of scaffolds were developed for tissue engineering of the aortic valve; an electrospun valvular scaffold and a knitted valvular scaffold. These scaffolds were compared in a physiologic flow system and in a tissue-engineering process. In fibrin gel enclosed human myofibroblasts were seeded onto both types of scaffolds and cultured for 23 days under continuous medium perfusion. Tissue formation was evaluated by confocal laser scanning microscopy, histology and DNA quantification. Collagen formation was quantified by a hydroxyproline assay. When subjected to physiologic flow, the spun scaffold tore within 6 h, whereas the knitted scaffold remained intact. Cells proliferated well on both types of scaffolds, although the cellular penetration into the spun scaffold was poor. Collagen production, normalized to DNA content, was not significantly different for the two types of scaffolds, but seeding efficiency was higher for the spun scaffold, because it acted as a cell impermeable filter. The knitted tissue constructs showed complete cellular in-growth into the pores. An optimal scaffold seems to be a combination of the strength of the knitted structure and the cell-filtering ability of the spun structure.

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Section: Introductionmentioning

confidence: 99%

Electrospinning versus knitting: two scaffolds for tissue engineering of the aortic valve

Lieshout¹,

Vaz²,

Rutten³

et al. 2006

Journal of Biomaterials Science, Polymer Edition

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“…The characteristic features of biodegradable stents, their solubility and natural absorption after a certain time period, may prevent the serious complications reported for the use of metallic stents [2] . Furthermore, biodegradable stents are expected to be used as drug delivery systems [18,19] and numerous studies regarding drug delivery by biodegradable stents are in progress [15,18,19] . Benign gastrointestinal strictures are usually managed by maintaining an unobstructed passage with periodic balloon dilatation.…”

Section: Discussionmentioning

confidence: 99%

Usefulness of biodegradable stents constructed of poly-l-lactic acid monofilaments in patients with benign esophageal stenosis

Saito

Tanaka²,

Andoh³

et al. 2007

WJG

124

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AIM:To report 13 patients with benign esophageal stenosis treated with the biodegradable stent. METHODS:We developed a Ultraflex-type stent by knitting poly-l -lactic acid monofilaments. RESULTS:Two cases were esophageal stenosis caused by drinking of caustic liquid, 4 cases were due to surgical resection of esophageal cancers, and 7 cases were patients with esophageal cancer who received the preventive placement of biodegradable stents for postendoscopic mucosal dissection (ESD) stenosis. The preventive placement was performed within 2 to 3 d after ESD. In 10 of the 13 cases, spontaneous migration of the stents occurred between 10 to 21 d after placement. In these cases, the migrated stents were excreted with the feces, and no obstructive complications were experienced. In 3 cases, the stents remained at the proper location on d 21 after placement. No symptoms of re-stenosis were observed within the follow-up period of 7 mo to 2 years. Further treatment with balloon dilatation or replacement of the biodegradable stent was not required. CONCLUSION:Biodegradable stents were useful for the treatment of benign esophageal stenosis, particularly for the prevention of post-ESD stenosis.

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“…The aforementioned biodegradable materials have proven to be biologically safe and have been used in various medical devices such as surgical sutures and bone nails. Experimental and clinical studies also revealed that dilation using biodegradable stents is effective in treating various stenotic lesions [6,7,8]. The characteristic features of biodegradable stents, their solubility and natural absorption after a certain period, may contribute to the prevention of serious complications reported in the use of metallic stents.…”

Section: Discussionmentioning

confidence: 99%

“…In these cases, it is considerably more important to prevent the incidence of long-term complications, because the patient’s prognosis is not associated with the cause of the stenosis. From this point, stents constructed from biodegradable materials are one of the most ideal tools for treating benign cases [6,7,8], since the degradable nature of the stent would prevent serious long-term complications. However, there are only a few reports regarding the use of biodegradable stents for benign gastrointestinal tract stenoses [9,10,11].…”

Section: Introductionmentioning

confidence: 99%

Newly Developed Biodegradable Stents for Benign Gastrointestinal Tract Stenoses: A Preliminary Clinical Trial

Tanaka¹,

Takahashi²,

Nitta³

et al. 2006

Digestion

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We developed an Ultraflex-type stent by knitting polylactic acid monofilaments. The purpose of this study was to evaluate the stent’s clinical usefulness for treating benign stenoses in the gastrointestinal tract. The radial force of the biodegradable stent was compared with those of commercially available metallic stents. The measured radial force of the new biodegradable stent was higher than that of commercially available metallic stents. The biodegradable stents were applied in 2 patients with benign gastrointestinal stenoses. The first patient was a 19-year-old female with esophageal stenosis, due to drinking of caustic potash in an attempt to commit suicide. The second patient was a 75-year-old male who had a stenosis at the anastomotic site after esophageal cancer resection. In both cases, the placement of the stent was performed successfully, and the patients’ complaints improved immediately after stent placement. There were no complications during stent placement. The stenosis had not recurred at the six-month follow-up examination. In conclusion, the newly developed biodegradable stents were useful in treating benign stenoses of the alimentary tract.

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New Tubular Bioabsorbable Knitted Airway Stent: Feasibility Assessment for Delivery and Deployment in a Dog Model

Cited by 32 publications

References 9 publications

Electrospinning versus knitting: two scaffolds for tissue engineering of the aortic valve

Electrospinning versus knitting: two scaffolds for tissue engineering of the aortic valve

Usefulness of biodegradable stents constructed of poly-l-lactic acid monofilaments in patients with benign esophageal stenosis

Newly Developed Biodegradable Stents for Benign Gastrointestinal Tract Stenoses: A Preliminary Clinical Trial

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