New triterpenoid saponins from Patrinia scabiosaefolia

Gao, Liang; Zhang, Lin; Li, Nan; Liu, Jiang-Yun; Cai, Peilie; Yang, Shilin

doi:10.1016/j.carres.2011.10.008

Cited by 30 publications

(15 citation statements)

References 6 publications

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“…The main chemical compositions of CS contain organic acid, triterrpenes, flavonoids and polyphenols. Oleanolic acid and ursolic acid, two major triterpene acids in CS, are effective on hepatoprotection, anti-inflammation, anti-tumor-promotion, antioxidant, and anti-hyperlipidemia [21][22][23][24]. The alteration of cytokine expression in our results may be caused by these anti-inflammatory chemicals included in CS extract.…”

Section: Discussionmentioning

confidence: 77%

Chaenomeles sinensis Koehne extract suppresses the development of atopic dermatitis-like lesions by regulating cytokine and filaggrin expression in NC/Nga mice

Cha¹,

Song²,

Lee³

et al. 2019

Int. J. Med. Sci.

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Chaenomeles sinensis Koehne (CS) has been used in a traditional oriental medicine for treating throat diseases, anaphylaxis, viral infection, and inflammation. This study investigated the underlying mechanism of anti-allergic effect of CS. Leaves of CS plants were dried, powdered, and then underwent extraction with DMSO. Both ELISA and western blotting were performed to evaluate cytokine concentration and the expression and activation of filaggrin and JNK. Five-week-old female NC/Nga mice were used as an AD-like mouse model by treating them with 2,4-dinitrochlorobenzene (DNCB). The secretion of TARC, MCP-1, and IL-8 is increased by TNF-α and IFN-γ in HaCaT cells, and CS extract inhibited the increased production of TARC, MCP-1, and IL-8. TNF-α and IFN-γ suppressed filaggrin expression by activating JNK. CS extract recovered the expression of filaggrin decreased by TNF-α and IFN-γ by blocking the activation of JNK. In vivo experiment, CS administration reduced thickening of the epidermis and infiltration of inflammatory cells into the dermis as compared to DNCB treatment. Moreover, the decrease of filaggrin expression due to DNCB treatment was recovered by CS administration. The serum IgE level was decreased by CS treatment. The levels of IL-4, IL-5, IL-13 and eotaxin in mouse splenocytes increased after treatment with concanavalin A, and the secretions of IL-4, IL-5, IL-13 and eotaxin were lower in the CS-treated group than in the DNCB group. These results may contribute to the development of a CS-based drug for the treatment of atopic dermatitis.

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Section: Discussionmentioning

confidence: 77%

Chaenomeles sinensis Koehne extract suppresses the development of atopic dermatitis-like lesions by regulating cytokine and filaggrin expression in NC/Nga mice

Cha¹,

Song²,

Lee³

et al. 2019

Int. J. Med. Sci.

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“…Based on previous literature, 10 bioactive agents have been identified (41), including iridoids (42), saponins (41,43), triterpenes (44,45) and lactones (46). Detailed chemical fingerprint of NMR can be reviewed in the above literature.…”

Section: Discussionmentioning

confidence: 99%

Ethanol extract of Patrinia scabiosaefolia induces the death of human renal cell carcinoma 786-O cells via SIRT-1 and mTOR signaling-mediated metabolic disruptions

Tang

Zhu

et al. 2017

Oncol Rep

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Recently, natural plant extracts have shown tremendous potential as novel antitumor drugs. Patrinia scabiosaefolia, a traditional prescription for inflammatory diseases, has been reported to effectively suppress various types of cancers. However, the mechanisms underlying its antitumor properties remain elusive. In the present study, we investigated the antitumor effects of an ethanol extract of Patrinia scabiosaefolia (EPS) on human renal cell carcinoma 786-O cells. After 24 h of incubation with EPS, the cell viability and colony number of 786-O cells were significantly decreased in a concentration-dependent manner as compared to the control group as determined by MTT and colony formation assays, respectively. The necrotic rate and apoptotic rate in the EPS exposure group were significantly higher than these rates noted in the control group as revealed by LDH release assay and Hoechst 33342/ PI double staining, respectively. At the concentration of 1.0 mg/ml, the necrotic and apoptotic rates reached 41.7±6.6 and 7.8±1.4%, respectively (P<0.01). However, the fluorescence intensity of intracellular calcium concentration ([Ca2+]i) was markedly elevated from 0.029±0.0007 to 0.060±0.003 (P<0.001) after the intervention of EPS. Moreover, the fluorescence intensity of intracellular ROS in the EPS exposure group was significantly higher (0.074±0.005) compared to that observed in the control group (0.033±0.001, P<0.001), which was partly attenuated by the specific antioxidant N-acetylcysteine (NAC). Furthermore, our results demonstrated that EPS significantly downregulated the expression of SIRT-1 and obviously induced the dephosphorylation of mTOR. Moreover, combined treatment with the SIRT-1 inhibitor nicotinamide and EPS was able to significantly enhance the induction of necrosis and reduction in cell viability of 786-O cells noted following treatment with EPS alone. In summary, we conclude that EPS induced the death of 786-O cells via SIRT-1 and mTOR signaling-mediated metabolic disruptions, which provide novel insight into the application of natural plant extracts for the treatment of cancers.

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“…Previous research on the chemical constituents of BaiJiangCao have revealed that it contains several compound classes. Triterpenoid saponins, iridoids, flavonoids, flavonones and polysaccharides are the dominant bioacitve constituents in the leaves of P. Villosa Juss and P. scabiosaefolia Fisch, which displayed potential ability of anti-tumor and anti-inflammatory (4,5,6,7,8,9). Other components, such as sterols and fatty acids were also confirmed (6,10,11,12).…”

Section: Introductionmentioning

confidence: 87%

Chemical composition of Essential oil from the leaves of two species of BaiJiangCao, Patrinia scabiosaefolia Fisch and Patrinia villosa (Thunb.) Juss.

Wu¹,

Ying²,

Xiang³

2016

Proceedings of the 2016 5th International Conference on Energy and Environmental Protection (ICEEP 2016)

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The essential oil obtained by the hydrodistillation of the leaves of Patrinia scabiosaefolia Fisch and Patrinia villosa (Thunb.) Juss were analyzed by a combination of capillary GC-FID and GC/MS analytic techniques. 51 components comprising 94.56% of essential oil in leaves of P. scabiosaefolia Fisch and 33 components comprising 89.87% of oil in leaves of P. Villosa Juss were identified, respectively. The principal ingredients of oil from P. scabiosaefolia Fisch were 3-Methylbutanoic acid, Palmitic acid, Hexanoic acid and cis-Anethol and the principal ingredients of oil from Patrinia villosa (Thunb.) Juss were Camphogen, 2-Methyl-6-hydroxyquinoline, β-Damascenone and β-Ionone. Nine common components were confirmed in the essential oil of P.

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New triterpenoid saponins from Patrinia scabiosaefolia

Cited by 30 publications

References 6 publications

Chaenomeles sinensis Koehne extract suppresses the development of atopic dermatitis-like lesions by regulating cytokine and filaggrin expression in NC/Nga mice

Chaenomeles sinensis Koehne extract suppresses the development of atopic dermatitis-like lesions by regulating cytokine and filaggrin expression in NC/Nga mice

Ethanol extract of Patrinia scabiosaefolia induces the death of human renal cell carcinoma 786-O cells via SIRT-1 and mTOR signaling-mediated metabolic disruptions

Chemical composition of Essential oil from the leaves of two species of BaiJiangCao, Patrinia scabiosaefolia Fisch and Patrinia villosa (Thunb.) Juss.

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