New Triterpenes of Lantana camara. A Comparative Study of the Constituents of Several Taxa

Hart, N. K.; Lamberton, J. A.; Sioumis, AA; Suares, H

doi:10.1071/ch9760655

Cited by 78 publications

(36 citation statements)

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“…Most of the compounds, namely 1-39, are based on the oleanane nucleus. Among the triterpenes with an oleanane nucleus, nineteen (1-19) have a common skeleton (Skeleton-I), ten (25-34) have Skeleton-II, two compounds (36, 37) have a common skeleton (Skeleton-III), and the other two Hart et al (1976aHart et al ( , 1976b …”

Section: Triterpenoidsmentioning

confidence: 99%

“…camara (leaves) lantic acid (57) Barua et al (1969); Saleh et al (1999) camaracinic acid (58) L. camara (aerial parts) Begum et al (1995) methyl ursoxylate (59) Hart et al (1976aHart et al ( , 1976b 1,2…”

Section: Triterpenoidsmentioning

confidence: 99%

“…; Lai et al (1998) 2 betulonol (67) L. camara (stems) Lai et al (1998) lantabetulic acid (69) L. camara (leaves and stems) Hart et al (1976aHart et al ( , 1976b lupeol analogue (68) L. camara L. (leaves) Hart et al (1976a) euphane lactone B (70-71), euphane lactone C (73-73), euphane lactone A (74) O 'Neill et al (1998) …”

Section: Triterpenoidsmentioning

confidence: 99%

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Genus Lantana: chemical aspects and biological activities

Sousa¹,

Costa²

2012

Rev. bras. farmacogn.

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Species of the genus Lantana, belonging to the family Verbenaceae, is among the various species studied scientifically. These species are mainly native to the tropical and subtropical regions of the Americas. Currently, they are present in various countries, where they are often grown as ornamental plants. For decades, species of Lantana have been of great interest for phytochemical, biological and pharmacological studies, which have been recently intensified. The components isolated from different species of Lantana cited in the literature constitute the focus of this review. Information ethnopharmacology of Lantana, as well as the activities of their different phytochemicals are discussed. In this review, it was observed that the genus Lantana has been widely studied in relation to its phytochemical components and terpenoids, flavonoids and phenylpropanoids are the more common secondary metabolites in Lantana. All these aspects, considered in this review, allow an evaluation of the ethnopharmacological potential of Lantana for the utilization of the large biomass of these plants.

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Section: Triterpenoidsmentioning

confidence: 99%

Section: Triterpenoidsmentioning

confidence: 99%

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Genus Lantana: chemical aspects and biological activities

Sousa¹,

Costa²

2012

Rev. bras. farmacogn.

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“…In spite of having many toxic effects this weed is also having anticancer (Gomes et al, 2010;Sathish et al, 2011), antibacterial (Rwangabo et al, 1988;Barreto et al, 2010), antifungal (Sharma et al, 2007), anti-diabetic (Garg et al, 1997), anti-inflammatory, analgesic, antimotility (Ghosh et al, 2010, anti-feedant, larvae repellent (Moffitt et al, 2010), anticonvulsant (Bisi-Johnson et al, 2011), antiulcer and antioxidant actions (Sathish et al, 2011). Oleanolic acid and ursolic acid are the major components, while LA and LB are the minor constituents obtained from Townsville prickly orange variety of lantana (Hart et al, 1976a). …”

Section: Toxic Components Of Lantana Camaramentioning

confidence: 99%

Lantana camara: An alien weed, its impact on animal health and strategies to control

Kumar¹,

Katiyar²,

Kumar³

et al. 2016

JEBAS

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KEYWORDS Lantana camara Lantadenes Allelopathy Hepatotoxic Poisonous ABSTRACTLantana camara is one of the most commonly known noxious weed distributed worldwide. The red flower variety (L. camara var. aculeata) of this weed is mainly toxic and usually prevalent in tropical and sub-tropical countries. Lantana leads to hepatotoxicity, photosensitization and intrahepatic cholestasis almost in all the animals. LA is the main toxic pentacyclic triterpenoid present in this weed. Lantadene toxicity leads to fatty degeneration, bile duct hyperplasia, gall bladder edema, degeneration of parenchymal cells and portal fibrosis observed on histopathological examination. L. camara toxicity causes fluctuation in hematological as well as in biochemical parameters. The management of toxic effects can be achieved by activated charcoal, vaccination and supportive therapy but are not much effective. Besides the harmful effects of this plant, there are some beneficial effects also including antiinflammatory, hepatoprotective action, antitumor action etc. The control of this weed is difficult because of its allelopathic action. Nowadays this plant is used in many recent advanced techniques like phytoremediation of particulate pollution, phytoextraction of heavy metals and many others. Thereby the use of this plant in the field of research can be an effective way to manage this alien weed. As far as the toxicity is concerned it can be prevented by the using conventional therapeutic methods along with immunological, nanotechnological and biotechnological approaches. The aim of this article is to discuss the information regarding its progression, mechanism by which it affect animals, pathological alterations, treatment and what strategies we can opt to get rid of this weed.

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“…The aqueous layer was further extracted with n-BuOH to give a n-BuOH soluble fraction and the aqueous layer. The AcOEt fraction showed the most potent anti-androgenic activity and was fractionated as described in the Experimental section to give new triterpenes, 1-6, along with known triterpenes, lantanolic acid (7), 4) 3-epipomolic acid (8), 5) lantic acid (9), 4) icterogenin (10), 6) lantadene A (11), 7) lantadene B (12), 7) ursomic acid (13) 8) and pomonic acid (14), 9) and the flavonols pachypodol (15) 10) and retusin (16), 11) which were recently reported as anti-emetic principles of Pogostemon cablin. 12) The high resolution (HR)-FAB-MS of 1 afforded a pseudo molecular ion [MH] ϩ at m/z 529.3533, corresponding to the molecular formula C 32 H 48 O 6 .…”

mentioning

confidence: 99%

Anti-androgenic Triterpenoids from the Brazilian Medicinal Plant, Cordia multispicata.

Kuroyanagi

Seki

Hayashi

et al. 2001

CHEMICAL & PHARMACEUTICAL BULLETIN

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In the course of our program to find anti-androgenic constituents from plant sources, we have isolated anti-androgenic neoflavones and flavonoids from Dalbergia conchinchinensis 1) and prenyl flavones from Sophora flavescens. 2)In further screening of plant extracts, methanol extracts of Cordia multispicata (Boraginaceae) were shown to have potent activity. C. multispicata is a Brazilian medicinal plant that is used as an expectorant and as a drug for contusion, and is mainly distributed in the Amazon area. No chemical constituents have been reported from C. multispicata, 3) however, a few reports on the constituents from other Cordia sp. plants have appeared. The anti-androgenic constituents were isolated from leaves of C. multispicata by activity-guided fractionation, to give six new ursane type triterpenoids along with known oleanane and ursane triterpenes having relatively novel structures. This paper deals with the isolation and structural elucidation of the new triterpenes, 1-6 from C. multispicata and their inhibitory activity against testosterone 5a-reductase.A methanol extract of leaves of C. multispicata showing anti-androgenic activity was partitioned between AcOEt and H 2 O. The aqueous layer was further extracted with n-BuOH to give a n-BuOH soluble fraction and the aqueous layer. The AcOEt fraction showed the most potent anti-androgenic activity and was fractionated as described in the Experimental section to give new triterpenes, 1-6, along with known triterpenes, lantanolic acid (7), 4) 3-epipomolic acid (8), 5) lantic acid (9), 4) icterogenin (10), 6) lantadene A (11), 7) lantadene B (12), 7) ursomic acid (13) 8) and pomonic acid (14), 9) and the flavonols pachypodol (15) 10) and retusin (16), 11) which were recently reported as anti-emetic principles of Pogostemon cablin. 12)The high resolution (HR)-FAB-MS of 1 afforded a pseudo molecular ion [MH] ϩ at m/z 529.3533, corresponding to the molecular formula C 32 H 48 O 6 . The IR spectrum of 1 showed absorptions at 3434 (OH) and 1730 (carbonyl) cm Ϫ1. 52-1 Yada, Shizuoka, 422-8526, Japan, Life Science Center, Lion Corporation, c 100 Tajima, Odawara, 256-0811, Japan, and Division of Pharmacognosy and Phytochemistry, National Institute of Health Sciences, d 1-18-1 Kamiyoga, Setagaya, Tokyo 158-8501, Japan. Received January 29, 2001; accepted April 13, 2001 Compounds 1-6 were isolated from the AcOEt soluble fraction of leaves of the Brazilian medicinal plant, Cordia multispicata, and their structures were elucidated to be 3b b,25-epoxy-21b b-acetoxy-3a a,22b b-dihydroxyurs-12-en-28-al (1), 3b b,25-epoxy-28-acetoxy-3a a,21b b,22b b-trihydroxyurs-12-ene (2), 21b b-acetoxy-22b b-hydroxy-3-oxours-12-en-28-al (3), 28-acetoxy-6b b,21b b,22b b-trihydroxy-3-oxours-12-ene (4), 21b b,22b b-dihydroxy-3-oxours-12-en-28-al (5) and 3b b,21b b,22b b-trihydroxyurs-12-en-28-al (6), respectively, by means of spectral data, especially two dimensional NMR techniques. Triterpenes having the hemiketal structure at the A-ring, an acyloxy group at C-22 and/or ket...

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New Triterpenes of Lantana camara. A Comparative Study of the Constituents of Several Taxa

Cited by 78 publications

References 0 publications

Genus Lantana: chemical aspects and biological activities

Genus Lantana: chemical aspects and biological activities

Lantana camara: An alien weed, its impact on animal health and strategies to control

Anti-androgenic Triterpenoids from the Brazilian Medicinal Plant, Cordia multispicata.

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