New trends in pharmacological control of neuropsychiatric symptoms of dementia

Scuteri, Damiana; Corasaniti, Maria Tiziana; Tonin, Paolo; Nicotera, Pierluigi; Bagetta, Giacinto

doi:10.1016/j.coph.2021.09.002

Cited by 8 publications

(5 citation statements)

References 48 publications

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“…This is fundamental since the glutamatergic [24,25] and serotonergic [26] mechanisms are significantly involved in aging and neurodegeneration and, thus, they are also involved in the mechanism of action of rapid acting antidepressants [27]. This finding could break new ground for the treatment of neuropsychiatric symptoms [28]. This deepening of the characterization of the neuropharmacological profile of BEO is fundamental to elucidate all of its properties since BEO may provide an effective option for the management of agitation that is closely connected to under-treated pain [29] and, unfortunately, that is managed with antipsychotics, doubling the risk of death caused by cardiocerebrovascular accidents in the elderly [30], something that is even more relevant during the pandemic [31].…”

Section: Discussionmentioning

confidence: 99%

Preclinical Characterization of Antinociceptive Effect of Bergamot Essential Oil and of Its Fractions for Rational Translation in Complementary Therapy

et al. 2022

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Bergamot essential oil (BEO) is endowed with consistent and reproducible antinociceptive and anti-allodynic properties when administered via an inhalation route. However, the effects of its main constituents and of its decolored (DEC) and deterpenated (DET) fractions, which are enriched in limonene or in linalool and linalyl acetate, respectively, on spontaneous motor activity related to anxiety and on formalin-induced licking/biting biphasic behavior have never been investigated before. Therefore, the present research aims to characterize the role of BEO components on an experimental pain model that is relevant to clinical translation. Under our present experimental conditions, a paper filter disc soaked with different volumes of the phytocomplex and of its fractions that was applied at the edge of the observation chamber allowed the effects on the spontaneous motor activity and on the formalin-induced nocifensive response in ddY-strain mice to be studied. The present research demonstrated the effects of the DEC fraction of BEO on motor activity and on formalin-induced licking/biting behavior for the first time, proving that limonene is implicated in reduced motor activity and that it is important for the analgesic effect.

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Section: Discussionmentioning

confidence: 99%

Preclinical Characterization of Antinociceptive Effect of Bergamot Essential Oil and of Its Fractions for Rational Translation in Complementary Therapy

et al. 2022

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“…Another important feature of the pharmacological activity of BEO for clinical use is its lack of sedative effects (that could increase cognitive deterioration), supported by the involvement of serotonergic neurotransmission [ 49 ]. This neuromodulation is a fundamental target during aging and neurodegeneration [ 50 ], as demonstrated by the action of rapid-acting antidepressants [ 51 ], which could represent a revolutionary therapy for the neuropsychiatric symptoms [ 52 ]. Therefore, the deep characterization of the analgesic properties of BEO, as well as of its fractions and components, via the transdermal route is fundamental since its engineered nanotechnological delivery system, NanoBEO, is administered via the same route and is the soundest candidate essential oil for investigation in the clinical management of pain and agitation.…”

Section: Discussionmentioning

confidence: 99%

Translational Value of the Transdermal Administration of Bergamot Essential Oil and of Its Fractions

et al. 2022

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The essential oil of bergamot (BEO) has consistently proven antinociceptive and antiallodynic properties. Accordingly, the analgesic efficacy of the decolored essential oil (DEC), with higher levels of limonene, and the deterpenated (DET) fraction, with higher levels of linalool and linalyl acetate, was investigated using a formalin test after inhalation. The present study was aimed at characterizing the effects of BEO, its components with the highest pharmacological activity (represented by linalool, limonene, and linalyl acetate), and its DEC and DET fractions on the formalin test after transdermal administration relevant to clinical translation through topical application. To this aim, the schedule of intervention involved administration immediately after formalin injection or as a 5 min pretreatment followed by washout in ddY-strain mice. This study demonstrates, for the first time, the significant analgesic effect of all three constituents in the first and second phases, accounting for the efficacy of the essential oil in the formalin test. While all fractions revealed equal activity toward the phytocomplex in the early phase, the reduction in time of licking/biting during the late phase was more markedly induced by DEC. Moreover, pretreatment with BEO and its fractions followed by washout did not produce a significant reduction in licking/biting time in both phases of formalin-induced nociceptive response.

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“…The studies found by the present search of databases and inspection of references in the literature demonstrate a main effect of essential oils on general well-being and sleep. However, these symptoms and the benefits of them might be linked to pain processing [ 86 ], although not always being detected by an appropriate measure tool, mainly in older patients and in the case of depression [ 87 ]. This is supported by meta-analysis that demonstrates the effectiveness of essential oils used as aromatherapy in the reduction of the intensity of cancer-related pain, assessed through unidimensional pain scales ( p = 0.002).…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Essential Oils in Relieving Cancer Pain: A Systematic Review and Meta-Analysis

Corasaniti

Bagetta

Morrone

et al. 2023

IJMS

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Over 80% of patients affected by cancer develops cancer-related pain, one of the most feared consequences because of its intractable nature, particularly in the terminal stage of the disease. Recent evidence-based recommendations on integrative medicine for the management of cancer pain underline the role of natural products. The present systematic review and meta-analysis aims at appraising for the first time the efficacy of aromatherapy in cancer pain in clinical studies with different design according to the most updated Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) 2020 recommendations. The search retrieves 1002 total records. Twelve studies are included and six are eligible for meta-analysis. The present study demonstrates significant efficacy of the use of essential oils in the reduction of the intensity of pain associated with cancer (p < 0.00001), highlighting the need for earlier, more homogeneous, and appropriately designed clinical trials. Good certainty body of evidence is needed for effective and safe management of cancer-related pain using essential oils by establishment of a step-by-step preclinical-to-clinical pathway to provide a rational basis for clinical use in integrative oncology. PROSPERO registration: CRD42023393182.

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New trends in pharmacological control of neuropsychiatric symptoms of dementia

Cited by 8 publications

References 48 publications

Preclinical Characterization of Antinociceptive Effect of Bergamot Essential Oil and of Its Fractions for Rational Translation in Complementary Therapy

Preclinical Characterization of Antinociceptive Effect of Bergamot Essential Oil and of Its Fractions for Rational Translation in Complementary Therapy

Translational Value of the Transdermal Administration of Bergamot Essential Oil and of Its Fractions

Efficacy of Essential Oils in Relieving Cancer Pain: A Systematic Review and Meta-Analysis

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