New Trends in Cognitive Aging and Mild Cognitive Impairment

Facal, David; Spuch, Carlos; Valladares-Rodríguez, Sonia

doi:10.3390/geriatrics7040080

Cited by 2 publications

(4 citation statements)

References 14 publications

(21 reference statements)

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“…Consistent with prior research, our study indicates a general acceptance of VR applications among older adults, with positive perceptions regarding their usefulness [10,18]. Participants predominantly favoured fully immersive and naturalistic VR applications, aligning with findings from Orr et al [15] and highlighting the value of ecological validity in the design of VR screening applications to ensure alignment with user preferences [28].…”

Section: Discussionsupporting

confidence: 88%

“…Within the healthcare domain, all forms of VR technology (semi-immersive, non-immersive and fully immersive) have been shown to be particularly valuable for cognitive and physical assessments, as well as interventions and rehabilitation [9]. For older adults, VR applications also provide a non-intrusive means of evaluating cognitive and physical capabilities, demonstrating superiority over conventional approaches [10]. For example, VR simulations can create immersive environments that mimic real-world scenarios, allowing healthcare professionals to assess cognitive functions such as spatial memory and problem-solving skills in a controlled and interactive setting [11,12].…”

Section: Introductionmentioning

confidence: 99%

“…While the TAM has been extensively employed to assess VR acceptance, it is essential to acknowledge that older adults with sensory impairments may encounter challenges in fully engaging with VR technologies. Both Shu and Woo [18] and Facal et al [10] highlighted the impact of sensory impairments on the acceptance and usability of VR applications among older adults. Factors such as cybersickness and medication-induced nausea further complicate the interaction with VR applications, especially within an older demographic [19].…”

Section: Introductionmentioning

confidence: 99%

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Acceptability of virtual reality to screen for dementia in older adults

Siette,

Adam,

Harris

2024

BMC Geriatr

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Background Early detection of dementia and cognitive decline is crucial for effective interventions and overall wellbeing. Although virtual reality (VR) tools offer potential advantages to traditional dementia screening tools, there is a lack of knowledge regarding older adults’ acceptance of VR tools, as well as the predictors and features influencing their adoption. This study aims to (i) explore older adults’ perceptions of the acceptability and usefulness of VR diagnostic tools for dementia, and (ii) identify demographic predictors of adoption and features of VR applications that contribute to future adoption among older adults. Methods A cross-sectional study was conducted involving community-dwelling older adults who completed online questionnaires covering demographics, medical history, technology acceptance, previous usage, and perceived usefulness and barriers to VR adoption. Multiple linear regression was employed to assess relationships between sociodemographic factors, prior technology use, perceived ease, usefulness, and intention to adopt VR-based diagnostic tools. Results Older adults (N = 77, Mage = 73.74, SD = 6.4) were predominantly female and born in English-speaking countries. Perceived usefulness of VR applications and educational attainment emerged as significant predictors of the likelihood to use VR applications for dementia screening. Generally, older adults showed acceptance of VR applications for healthcare and dementia screening. Fully immersive applications were preferred, and older adults were mostly willing to share electronic information from screening with their healthcare providers. Conclusions The field of research on VR applications in healthcare is expanding. Understanding the demographic characteristics of populations that stand to benefit from healthcare innovations is critical for promoting adoption of digital health technologies and mitigating its barriers to access.

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Section: Discussionsupporting

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Acceptability of virtual reality to screen for dementia in older adults

Siette,

Adam,

Harris

2024

BMC Geriatr

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“…MCI is a distinct stage of cognitive loss that falls between the expected cognitive decline of physiological aging and the more serious loss of mental abilities associated with dementia. It is characterized by impairments in memory, language, thinking, or judgment that are severe enough to interfere with daily life [ 120 ]. Individuals with MCI have an increased risk of developing dementia caused by AD or other neurological conditions [ 121 ].…”

Section: Effects Of Lpls On Cognitive Declinementioning

confidence: 99%

Lysophospholipids: A Potential Drug Candidates for Neurodegenerative Disorders

et al. 2022

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Neurodegenerative diseases (NDs) commonly present misfolded and aggregated proteins. Considerable research has been performed to unearth the molecular processes underpinning this pathological aggregation and develop therapeutic strategies targeting NDs. Fibrillary deposits of α-synuclein (α-Syn), a highly conserved and thermostable protein, are a critical feature in the development of NDs such as Alzheimer’s disease (AD), Lewy body disease (LBD), Parkinson’s disease (PD), and multiple system atrophy (MSA). Inhibition of α-Syn aggregation can thus serve as a potential approach for therapeutic intervention. Recently, the degradation of target proteins by small molecules has emerged as a new therapeutic modality, gaining the hotspot in pharmaceutical research. Additionally, interest is growing in the use of food-derived bioactive compounds as intervention agents against NDs via functional foods and dietary supplements. According to reports, dietary bioactive phospholipids may have cognition-enhancing and neuroprotective effects, owing to their abilities to influence cognition and mental health in vivo and in vitro. However, the mechanisms by which lipids may prevent the pathological aggregation of α-Syn warrant further clarification. Here, we review evidence for the potential mechanisms underlying this effect, with a particular focus on how porcine liver decomposition product (PLDP)-derived lysophospholipids (LPLs) may inhibit α-Syn aggregation.

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New Trends in Cognitive Aging and Mild Cognitive Impairment

Abstract: In this editorial, we aim to highlight some lessons learned in our field and to discuss some open questions regarding the continuum between healthy cognitive aging and dementia [...]

Cited by 2 publications

References 14 publications

Acceptability of virtual reality to screen for dementia in older adults

Acceptability of virtual reality to screen for dementia in older adults

Lysophospholipids: A Potential Drug Candidates for Neurodegenerative Disorders

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