New Treatments for Hair Loss

Vañó‐Galván, Sergio; Camacho, Francisco

doi:10.1016/j.adengl.2017.02.016

Cited by 16 publications

(14 citation statements)

References 75 publications

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“…This kinase plays a crucial role in the function of the Axin-based β-catenin destruction complex. Inhibitors of GSK3β are sought for as drug candidates for various defects in skin, such as vitiligo [41] and androgenic alopecia [27,42], and in the bone, such as bone fracture [27] and osteoporosis [43]; other applications are also concievable. It is clear that novel molecules with GSK3β as the target are still in demand.…”

Section: Wnt Activators From Natural Sourcesmentioning

confidence: 99%

Small Molecule Wnt Pathway Modulators from Natural Sources: History, State of the Art and Perspectives

Blagodatski

Klimenko

Jia

et al. 2020

Cells

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The Wnt signaling is one of the major pathways known to regulate embryonic development, tissue renewal and regeneration in multicellular organisms. Dysregulations of the pathway are a common cause of several types of cancer and other diseases, such as osteoporosis and rheumatoid arthritis. This makes Wnt signaling an important therapeutic target. Small molecule activators and inhibitors of signaling pathways are important biomedical tools which allow one to harness signaling processes in the organism for therapeutic purposes in affordable and specific ways. Natural products are a well known source of biologically active small molecules with therapeutic potential. In this article, we provide an up-to-date overview of existing small molecule modulators of the Wnt pathway derived from natural products. In the first part of the review, we focus on Wnt pathway activators, which can be used for regenerative therapy in various tissues such as skin, bone, cartilage and the nervous system. The second part describes inhibitors of the pathway, which are desired agents for targeted therapies against different cancers. In each part, we pay specific attention to the mechanisms of action of the natural products, to the models on which they were investigated, and to the potential of different taxa to yield bioactive molecules capable of regulating the Wnt signaling.

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Section: Wnt Activators From Natural Sourcesmentioning

confidence: 99%

Small Molecule Wnt Pathway Modulators from Natural Sources: History, State of the Art and Perspectives

Blagodatski

Klimenko

Jia

et al. 2020

Cells

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“…Most studies are sponsored by device manufacturers, which could be a potential source of publication bias . In order for LLLT to be predictable and reproducible, therapeutic parameters, including wavelength, irradiance and exposure time, must be established …”

Section: Key Issues In Hair Loss: From Physiology To Treatmentmentioning

confidence: 99%

Dermatology today and tomorrow: from symptom control to targeted therapy

Blume-Peytavi

Bagot

Tennstedt

et al. 2018

Acad Dermatol Venereol

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For many decades and until recently, medical approach to dermatologic diseases has been based on the physician's ability to recognize and treat symptoms. Nowadays, advances in the understanding of the biology of diseases and in technologies for intervening against them have allowed physicians to diagnose and treat underlying disease processes rather than simply addressing the symptoms. This means that rather than addressing ‘the disease in humans’, physicians can now address the particular pathologic (biologic, molecular) disturbance as it presents in the individual patient, i.e., physicians now can practice something much closer to ‘personalized medicine’, leading to greater benefits for the patients and the health of society in general. The deeper understanding of ultraviolet radiation, the importance of photoprotection and increased knowledge about signalling pathways of melanoma and carcinoma have led to more complete care for the dermatologic patient. The current popularity for excessive exposure to the sun, without adequate application of the appropriate photoprotection remedies, is the origin of melanoma, but also for the weakening of the structure and functions of the skin. Indeed, fragility of the skin can affect humans around the world. In the senior population, this skin fragility is accompanied by pruritus, whereas atopic dermatitis is an inflammatory disease with highest prevalence in children and adolescents. Acne, the number one reason for dermatologic consultations worldwide, increases its prevalence in adolescents and in females. Senescent alopecia affects humans after menopause and andropause. The articles in this publication present an overview of the current advanced understanding of the diagnosis and therapeutic approaches in 6 fields of dermatology – dermatopaediatry and gerontodermatology, oncodermatology, hair loss, atopic dermatitis, photoprotection and acne – and thereby serve as a useful compendium of updated information and references for all healthcare professionals who see patients with presentations of the symptoms of these diseases.

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“…Currently, minoxidil and finasteride are the only two drugs that have been approved by the United States Food and Drug Administration (FDA) to treat AGA, the most common type of hair loss. 2,3 Minoxidil is a multifunctional biological response regulator, which contributes to accelerating hair growth, thickening the skin and prolonging the anagen phase of hair cycle. 4 It is widely used in treating many kinds of hair loss.…”

Section: Introductionmentioning

confidence: 99%

Hair Growth-Promoting Effect of Resveratrol in Mice, Human Hair Follicles and Dermal Papilla Cells

Zhang¹,

Ni²,

Huang³

et al. 2021

CCID

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Background: Oxidative damage has been found in various types of hair loss. As a polyphenolic phytoalexin, resveratrol (RSV) is known as an antioxidant, anti-inflammatory and anti-apoptotic agent.Objective: Thus, we aim to examine the effects of RSV on hair growth. Methods: In vivo C57BL/6 mice were used to evaluate the effects of RSV on hair cycle, hair length, skin thickness, hair follicle diameter, hair cycle score and the percentage of hair cycle stage. Then hair shaft length and hair cycle were evaluated by human hair follicles (HFs) ex vivo. The proliferative activities of human dermal papilla cells (hDPCs) cultured in vitro with RSV were assessed using RTCA. The ability of RSV to protect hDPCs against H 2 O 2 -induced oxidative damage is examined by a ROS assay kit. Results: Topical application of RSV significantly promoted hair growth and stimulated the transition of hair cycle from telogen into the anagen phase on shaved C57BL/6 mice. Ex vivo experiments showed that RSV increased the hair shaft length of HFs and delayed the entry into catagen. In vitro experiments indicated that RSV proliferated hDPCs and prevented hDPCs from oxidative damage caused by H 2 O 2 . Conclusion: RSV can promote hair growth and may be a potential candidate for the treatment of hair loss.

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New Treatments for Hair Loss

Cited by 16 publications

References 75 publications

Small Molecule Wnt Pathway Modulators from Natural Sources: History, State of the Art and Perspectives

Small Molecule Wnt Pathway Modulators from Natural Sources: History, State of the Art and Perspectives

Dermatology today and tomorrow: from symptom control to targeted therapy

Hair Growth-Promoting Effect of Resveratrol in Mice, Human Hair Follicles and Dermal Papilla Cells

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