New treatment sequence protocol to reconstruct locally advanced breast cancer

Abstract

Our new treatment sequence protocol offers a simpler, more advantageous approach to LABC. We hypothesize equivalent oncological efficacy, optimized oncological management and surgical planning. The aim was to shorten and simplify the reconstructive journey through a single operation including gold-standard reconstruction, offering better cosmesis, fewer complications and reduced costs.

ITADE flap after mastectomy for locally advanced breast cancer: A good choice for mid‐sized defects of the chest wall, based on a systematic review of thoracoabdominal flaps

“…Neoadjuvant radiotherapy increases tumor resectability, and adjuvant radiotherapy is used to decrease local recurrence. If negative local effects of radiotherapy are present in the flaps after radiotherapy, autologous flaps can be considered after primary surgery for LABC . TAFs allow skin closure and radiotherapy, and autologous flaps can be performed later.…”

Preoperative Radiotherapy Is Not Associated with Increased Post-mastectomy Short-term Morbidity: Analysis of 77,902 Patients

“…Although this definition may underestimate the number of patients who received NRT, we believe that this limitation is reduced considering that the current practice trend is for patients to undergo surgery 6 weeks post-NRT completion. 5 Nevertheless, for the cohort receiving NRT, we were unable to determine the exact timing of radiotherapy (ie, NRT was delivered in the 90 days preceding the surgery, but this could range from 1–12 weeks before the surgery).…”

“…3, 4 As compared with NCT alone, the combination of NRT and NCT promoted complete pathological response, clinical remission, and increased median survival. 5 This has allowed breast-conserving surgery to be performed with enhanced safety and frequency, with rates reaching 43–92%. 6–10 Isolated NRT has also been found to promote favorable long-term survival among women undergoing breast-conserving surgery 11, 12 or mastectomy.…”

Immediate autologous breast reconstruction after neoadjuvant chemoradiotherapy for breast cancer: initial results of the first 29 patients

“…We have previously published a protocol for treatment of locally advanced breast cancer with autologous breast reconstruction that is simpler, shorter and results in a good cosmetic outcome as compared with traditional protocols …”

“…12,13 We have previously published a protocol for treatment of locally advanced breast cancer with autologous breast reconstruction that is simpler, shorter and results in a good cosmetic outcome as compared with traditional protocols. 14 Within this algorithm, the patients are treated with preoperative neoadjuvant chemotherapy and then with radiation before the mastectomy. Numerous reports have shown that this is oncologically safe.…”