Abstract:The broadly accepted and deeply rooted belief in developmental biology was that terminally differentiated cells had lost the potential to produce other cell types. In 2006, however, mouse somatic cells were reprogrammed as induced pluripotent stem (iPS) cells that resembled embryonic stem cells. This therapeutic promise is being challenged by thousand of researchers worldwide to understand the ability of these cells to reverse biological clocks. Utilizing both "forward" and "reverse" genetic approaches with th… Show more
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