New Topics in Vasopressin Receptors and Approach to Novel Drugs: Role of the Vasopressin Receptor in Psychological and Cognitive Functions

Egashira, Nobuaki; Mishima, Kenichi; Iwasaki, Katsunori; Oishi, Ryozo; Fujiwara, Michihiro

doi:10.1254/jphs.08r14fm

Cited by 50 publications

(29 citation statements)

References 71 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…V1aR-KO and V1bR-KO mice were shown to exhibit impaired social interaction compared with WT mice (132,135). In addition, V1bR-KO mice exhibited reduced social motivation in an olfactory discrimination task, but normal motivation after food deprivation, indicating that the deficit in motivated behavior is not general (533).…”

Section: Social Interaction and Social Communicationmentioning

confidence: 96%

Vasopressin V1a and V1b Receptors: From Molecules to Physiological Systems

Koshimizu

Nakamura

Egashira

et al. 2012

Physiological Reviews

Self Cite

324

297

View full text Add to dashboard Cite

The neurohypophysial hormone arginine vasopressin (AVP) is essential for a wide range of physiological functions, including water reabsorption, cardiovascular homeostasis, hormone secretion, and social behavior. These and other actions of AVP are mediated by at least three distinct receptor subtypes: V1a, V1b, and V2. Although the antidiuretic action of AVP and V2 receptor in renal distal tubules and collecting ducts is relatively well understood, recent years have seen an increasing understanding of the physiological roles of V1a and V1b receptors. The V1a receptor is originally found in the vascular smooth muscle and the V1b receptor in the anterior pituitary. Deletion of V1a or V1b receptor genes in mice revealed that the contributions of these receptors extend far beyond cardiovascular or hormone-secreting functions. Together with extensively developed pharmacological tools, genetically altered rodent models have advanced the understanding of a variety of AVP systems. Our report reviews the findings in this important field by covering a wide range of research, from the molecular physiology of V1a and V1b receptors to studies on whole animals, including gene knockout/knockdown studies.

show abstract

Section: Social Interaction and Social Communicationmentioning

confidence: 96%

Vasopressin V1a and V1b Receptors: From Molecules to Physiological Systems

Koshimizu

Nakamura

Egashira

et al. 2012

Physiological Reviews

Self Cite

324

297

View full text Add to dashboard Cite

show abstract

“…These findings may be due to the modulation of peripheral secretion caused by alterations of similar regulations due to HCB mechanisms (mentioned above) acting on the SON and/or the PVN or in the NH. Our results may correlate with the findings of increased plasma and/or cerebrospinal AVP levels in patients with anxiety disorders [21]. Several anxiety disorders are associated with elevated AVP, e.g.…”

Section: Discussionsupporting

confidence: 90%

“…It is accepted that AVP has anxiogenic [21,147], while OXT has anxiolytic [148] effects, and that AVP increases intermale aggression, whereas OXT is involved particularly in maternal care and aggression [6,46]. Regulation of the neuropeptides is implemented by many factors [5], including the neurogenic systems of biogenic amines, e.g.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Study of neurogenic involvement in arginine-vasopressin and oxytocin release under basal and environmentally stimulated conditions

Nagyéri¹

View full text Add to dashboard Cite

“…Both vasopressin 1A and 1B receptors are widely distributed in the brain including the hypothalamus (Egashira et al 2009). Vasopressin 1B receptors are also located in the pituitary and play a role in the control of HPA axis and stress-related behaviors.…”

Section: Discussionmentioning

confidence: 99%

Effects of atosiban on stress-related neuroendocrine factors

Babic¹,

Pokusa²,

Danevova³

et al. 2015

Journal of Endocrinology

View full text Add to dashboard Cite

Atosiban, an oxytocin/vasopressin receptor antagonist, is used to decrease preterm uterine activity. The risk of preterm delivery is undoubtedly associated with stress, but potential side effects of atosiban on neuroendocrine functions and stress-related pathways are mostly unknown. These studies were designed to test the hypothesis that the chronic treatment of rats with atosiban modulates neuroendocrine functions under stress conditions. Male rats were treated (osmotic minipumps) with atosiban (600 mg/kg per day) or vehicle and were restrained for 120 min/day for 14 days. All animals were treated with a marker of cell proliferation 5-bromo-2-deoxyuridine. Anxiety-like behavior was measured using an elevated plus-maze. Treatment with atosiban failed to modify plasma concentrations of the stress hormones ACTH and corticosterone, but led to a rise in circulating copeptin. Atosiban increased prolactin levels in the non-stressed group. Oxytocin receptor mRNA levels were increased in rats exposed to stress. Treatment with atosiban, in both control and stressed animals, resulted in a decrease in oxytocin receptor gene expression in the hypothalamus. No changes were observed in vasopressin receptor 1A and 1B gene expression. The decrease in hippocampal cell proliferation induced by stress exposure was not modified by atosiban treatment. This study provides the first data, to our knowledge, revealing the effect of atosiban on gene expression of oxytocin receptors in the brain. Atosiban-induced enhancement of plasma copeptin indicates an elevation in vasopressinergic tone with potential influence on water-electrolyte balance.

show abstract

New Topics in Vasopressin Receptors and Approach to Novel Drugs: Role of the Vasopressin Receptor in Psychological and Cognitive Functions

Cited by 50 publications

References 71 publications

Vasopressin V1a and V1b Receptors: From Molecules to Physiological Systems

Vasopressin V1a and V1b Receptors: From Molecules to Physiological Systems

Study of neurogenic involvement in arginine-vasopressin and oxytocin release under basal and environmentally stimulated conditions

Effects of atosiban on stress-related neuroendocrine factors

Contact Info

Product

Resources

About