New topical treatments for psoriasis

Chiricozzi, Andrea; Pitocco, Rossella; Saraceno, Rosita; Nisticò, Steven Paul; Giunta, Alessandro; Chimenti, Sergio

doi:10.1517/14656566.2014.875159

Cited by 41 publications

(20 citation statements)

References 49 publications

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“…Histological examination reveals different patterns, however collagen fiber degeneration and dermal mucin deposition associated with palisaded granulomatous inflammation are the most frequently reported (20)(21)(22). Its pattern differs from the most common dermatoses (23)(24)(25)(26)(27).…”

Section: Discussionmentioning

confidence: 88%

Granuloma Annularis Revealing Wegener's Granulomatosis

Porto

Proietta

Mellai

et al. 2014

Int J Immunopathol Pharmacol

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Skin manifestations are often associated with systemic autoimmune diseases (SAD). Some SAD, such as systemic lupus erythematosus, psoriatic arthritis and scleroderma display pathognomonic dermatological features, whereas other systemic diseases such as sarcoidosis, vasculitis and rheumatoid arthritis can present with non-specific skin manifestations that range from erythema nodosum to necrotic lesions. Here we report the case of a 25-year-old man with uveitis, polyarthrirtis, pulmonary involvement, nephrotic syndrome, cutaneous granuloma and pneumonia by E. coli.Skin manifestations are often associated to systemic autoimmune diseases (SAD). Some SAD, such as systemic lupus erythematosus, psoriatic arthritis and scleroderma display dermatological features that are pathognomonic, whereas other systemic diseases such as sarcoidosis, vasculitis and rheumatoid arthritis can present with non-specific skin manifestations that range from erythema nodosum to necrotic lesions (l, 2). Differential diagnosis among granulomatous diseases can be difficult, since they can present with similar or overlapping clinical features, thus auto-antibodies, such as antineutrophil cytoplasm antibodies (ANCA) are often helpful to make a definitive diagnosis (3, 4). Here we report the case of a 25-year-old man with uveitis, polyarthrirtis, pulmonary involvement, nephrotic syndrome, cutaneous granuloma and pneumonia by Escherichia coli. Case reportA 25-year-old man was admitted to our Department because of fever (38.5°C), cough and malaise which had initiated three months previously and was resistant to antibiotic therapy. On physical examination, he showed symmetrical and additive polyarthritis localized to the large joints of the lower limbs and to the large and small joints of the upper limbs, conjuntival redness, later identified as anterior uveitis, and a pulmonary abolition of the murmur at the right lower lobe. Skin examination detected small reddish nodules on the right elbow, where the skin was dry and scaly (Fig. 1). Laboratory tests showed normochromic normocytic anemia (haemogobin: 11.2 g/dL), increased C reactive protein (C-RP

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Section: Discussionmentioning

confidence: 88%

Granuloma Annularis Revealing Wegener's Granulomatosis

Porto

Proietta

Mellai

et al. 2014

Int J Immunopathol Pharmacol

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“…Nevertheless, limited studies assessed their efficacy and safety in the treatment of plaque psoriasis and clinical outcomes on their therapeutic benefits are controversial (Brune, Miller, Lin, Cotrim-Russi, & Paller, 2007;Zonneveld et al, 1998). Eventually, calcineurin inhibitors could be taken into consideration as a maintenance therapy after a satisfactory response with steroid therapy (Chiricozzi et al, 2014) or in case of failure to the other more common local therapies. However, clinical evidence of their beneficial effects in corticosteroid-sensitive areas (namely, face, intertriginous areas, and the anogenital region) has been reported.…”

Section: Topical Calcineurin Inhibitorsmentioning

confidence: 99%

“…Of note, the association with phototherapy and calcineurin inhibitors should be avoided and photoprotection should be recommended (Nast et al, 2007). Eventually, calcineurin inhibitors could be taken into consideration as a maintenance therapy after a satisfactory response with steroid therapy (Chiricozzi et al, 2014) or in case of failure to the other more common local therapies.…”

Section: Topical Calcineurin Inhibitorsmentioning

confidence: 99%

Treatment of psoriasis with topical agents: Recommendations from a Tuscany Consensus

Chiricozzi

Pimpinelli

Ricceri

et al. 2017

Dermatologic Therapy

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Psoriasis is a chronic and relapsing inflammatory skin disease, clinically characterized by erythematous and scaly plaques. Treatment approach is mainly driven by disease severity, though several factors should be considered in order to identify the optimal therapeutic choice. Mild psoriasis may be treated with a wide array of topical agents including corticosteroids, vitamin D analogs, keratolytics, and calcipotriol/betamethasone propionate compound. Because guidelines may not provide practical indications regarding the therapeutic approach, the use of topical agents in psoriasis is more individually tailored. In order to homogenize the standard of care, at least in a local setting, we collected the real-life-based recommendations for the use of topical therapies from an expert panel, the Tuscany Consensus Group on Psoriasis, representing all leading centers for psoriasis established in Tuscany. With this document, this consensus group sought to define principles guiding the selection of therapeutic agents with straightforward recommendations derived from a real-life setting.

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“…It has been observed in numerous clinical studies that the nervous system has an impact on the progress and severity of the disease; indeed, it is known that emotional stress, anxiety, and depression form the onset (triggers) and exacerbation of PsO, suggesting the presence of a link between the immune system and the nervous system (Farber, Nickoloff, Recht, & Fraki, ; Seville, ). Clinical manifestations of PsO are pustular, plaque, guttate, inverse, and erythrodermic PsO (Chiricozzi et al, ). Various treatments have been proposed to control the disease; in particular, calcineurin inhibitors have been proposed for the treatment of inverse PsO (Dattola et al, ); laser treatment is utilized to treat pustular PsO (Nisticò et al, ); excimer light has been proposed in the management of palmo‐plantar PsO (Nisticò, Saraceno, Stefanescu, et al, ); and systemic treatments such as acitretin, cyclosporine, and methotrexate are the main treatments in moderate and severe cases.…”

Section: Introductionmentioning

confidence: 99%

“…PsO resistant to these drugs may be treated with biological drugs (Rader, ). Topical ointments with vitamin A, vitamin D, and corticosteroid derivatives are used in the treatment of mild PsO (Chiricozzi et al, ). Among these topical treatments, various combinations of topical ointments, such as vitamin D derivatives and corticosteroids, have been proposed.…”

Section: Introductionmentioning

confidence: 99%