New topical treatment of symptomatic internal hemorrhoids in a general practice setting

Miškulin, Maja; Lalić, Zdenka; Dumić, Albina; Miškulin, Ivan; Šebo, Damir; Včev, Aleksandar

doi:10.1016/j.eujim.2016.08.133

Cited by 2 publications

(4 citation statements)

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“…Some recent studies have shown how oral usage of flavonoid-based drugs can be successfully applied in the conservative treatment of internal hemorrhoids (17)(18)(19)(20)(21)(22) and also as an adjunct therapy in the patients after the hemorrhoidectomy (23). However, its efficiency in the form of topic preparations intended for patients suffering from the symptomatic internal hemorrhoid Grades 1 and 2 has not been demonstrated, which was the main reason for the present study.…”

Section: Discussionmentioning

confidence: 79%

“…Flavonoids and phenol acids in propolis represent the main compounds responsible for its various curative effects (16). In recent years, there have been some attempts in the oral usage of flavonoid-based drugs, such as venotonic flavonoid micronized purified flavonoid fraction (MPFF), in the conservative treatment of internal hemorrhoids that all concluded how these substances could be considered an effective and well-tolerated agent in the treatment of acute episodes of hemorrhoids (17)(18)(19)(20)(21)(22). Besides that, there is also the study which had investigated potential clinical use of MPFF for the treatment of symptoms after hemorrhoidectomy with the conclusion that MPFF used in combination with short-term antibiotic and anti-inflammatory medication can reduce both the duration and extent of post-operative symptoms and wound bleeding following hemorrhoidectomy (23).…”

Section: Introductionmentioning

confidence: 99%

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New Topical Treatment of Symptomatic Internal Haemorrhoids in a General Practice Setting

Miškulin

Lalić

Dumić

et al. 2018

JHSCI

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Introduction: Oral usage of flavonoid-based drugs can be successfully applied in the conservative treatment of internal haemorrhoids; however, its efficiency in a form of topical preparations has not been demonstrated yet. The aim of the present study was to determine the efficiency of ointment with propolis extract (containing minimally 115 mg/kg of flavonoid galangin) in relief and suppression of the symptomatic internal haemorrhoids grade 1 and 2 (bleeding, prolapse, pain, and itching). Methods: This prospective cohort epidemiological study that included 46 participants of both genders, mean age 53.6±14.3 years, was conducted in the general practice setting in Osijek, Croatia and lasted for three months. A specially designed questionnaire was used to collect demographic data and data concerning the haemorrhoid disease symptoms and to evaluate the intensity of the latter data according to the scale defined in the research protocol. Results: The study showed statistically significant improvements in the intensity of all the symptoms connected with the internal haemorrhoids grade 1 and 2 (p<0.001) during the follow up period, as well as statistically significant differences in proportions of participants with and without of the each of the analysed symptoms before and after the therapy (p<0.001). After three months of therapy with ointment containing propolis extract 82.7% patients (38/46) had none of the analysed symptoms. Conclusions: Ointment with propolis extract efficiently affected all the analysed symptoms of the haemorrhoid disease thus having a very significant place within the conservative treatment of haemorrhoids.

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Section: Discussionmentioning

confidence: 79%

Section: Introductionmentioning

confidence: 99%

New Topical Treatment of Symptomatic Internal Haemorrhoids in a General Practice Setting

Miškulin

Lalić

Dumić

et al. 2018

JHSCI

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“…Some recent studies have shown the efficiency of honey usage in the treatment of haemorrhoids. 14 Considering the high price of synthetic flavonoid drugs and their unavailability to the public, we decided to introduce and study a medicine almost similar and even with a higher percentage of flavonoids by natural compounds and low complication in the form of lotions. Using natural flavonoids in olive oil and honey propolis, we prepared a lotion and evaluated its therapeutic and side effects compared with anti-haemorrhoid ointment (containing hydrocortisone and lidocaine), which is routinely used today as treatment.…”

Section: How This Study Might Affect Research Practice or Policymentioning

confidence: 99%

“…Flavonoids are also found in honey propolis, including quercetin, myricetin, chrysin, apigenin, luteolin, pinocembrin and pinobanksin. Some recent studies have shown the efficiency of honey usage in the treatment of haemorrhoids 14…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the efficacy and safety of an innovative flavonoid lotion in patients with haemorrhoid: a randomised clinical trial

Razdar,

Panahi,

Mohammadi

et al. 2023

BMJ Open Gastroenterol

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ObjectiveHaemorrhoids are one of the most common gastrointestinal and anal diseases. In olive oil and honey propolis, flavonoids have beneficial effects on improving vascular function and decreasing vascular resistance. In this study, we aimed to produce a combination of these two substances in the form of lotions and assess their healing and side effects in comparison with routine treatment, anti-haemorrhoid ointment (containing hydrocortisone and lidocaine).DesignIn this randomised clinical trial study, 86 patients with grade 2 or more haemorrhoid degrees, diagnosed by colonoscopy, were divided into two groups, the case (n=44) and control (n=42). The case group was treated with flavonoid lotion, and the control group was treated with anti-haemorrhoid ointment two times per day for 1 month. Patients were followed weekly with history and physical examination. The data of the two groups were collected before and after the intervention and statistically analysed.ResultsPost-treatment reduction in haemorrhoid grade was significant in the case group (p=0.02). This ratio was insignificant in the control group (p=0.139). Flavonoid lotion (p<0.05) significantly reduced the signs and symptoms of haemorrhoids more than anti-haemorrhoid ointment.ConclusionAccording to the results, flavonoid lotion can be an excellent alternative to topical chemical drugs, such as anti-haemorrhoid ointment, in treating haemorrhoid disease. Besides its effectiveness and safety, it can be easily manufactured and widely available to patien

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New topical treatment of symptomatic internal hemorrhoids in a general practice setting

Cited by 2 publications

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New Topical Treatment of Symptomatic Internal Haemorrhoids in a General Practice Setting

New Topical Treatment of Symptomatic Internal Haemorrhoids in a General Practice Setting

Evaluation of the efficacy and safety of an innovative flavonoid lotion in patients with haemorrhoid: a randomised clinical trial

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