“…Case-by-case determination of exposure and hazard data for each application and individual NM variant is not possible due to the time and cost required, as well as the ethical challenges inherent in animal experimentation, and thus there is a strong motivation to develop in silico models that can predict human exposure to, and impacts of, NMs based on a reduced set of input parameters, as part of an integrated approach to testing and assessment (IATA). An example of the use of computational tools in the context of risk assessment was introduced by Mollá et al , 1 who recently proposed NanoSerpa, an application for the risk assessment of NMs in the insurance sector, which was developed by integrating hazard-related data and optimized exposure models. The focus of NanoSerpa is on estimation of the insurance liability arising from accidental NMs spills during production, transport or use of NMs-containing products, based on input data regarding the type of NM and the accident scenario, utilising probabilistic models to predict emission, health hazard values and risk indices.…”