New tools for shaping plasticity to enhance recovery after stroke

Motolese, Francesco; Capone, Fioravante; Lazzaro, Vincenzo Di

doi:10.1016/b978-0-12-819410-2.00016-3

Cited by 14 publications

(13 citation statements)

References 156 publications

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“…As previously mentioned, stroke represents the leading cause of disability in the world [ 11 , 12 ]. Physical rehabilitation is a key part of post-acute management [ 47 ]. Studies have shown that starting rehabilitation in the first 2 weeks contributes to a reduction in long-term disability [ 48 ].…”

Section: Resultsmentioning

confidence: 99%

“…11,12 Physical rehabilitation is a key part of post-acute management. 47 Studies have shown that starting rehabilitation in the first 2 weeks contributes to a reduction in long-term disability. 48 A Cochrane review reported the benefits of rehabilitation therapy in restoring function and mobility in upper limbs paresis following stroke, compared to patients not treated with rehabilitation therapy.…”

Section: Rehabilitation Appsmentioning

confidence: 99%

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Smartphone App in Stroke Management: A Narrative Updated Review

et al. 2022

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The spread of smartphones and mobile-Health (m-health) has progressively changed clinical practice, implementing access to medical knowledge and communication between doctors and patients. Dedicated software called Applications (or Apps), assists the practitioners in the various phases of clinical practice, from diagnosis to follow-up and therapy management. The impact of this technology is even more important in diseases such as stroke, which are characterized by a complex management that includes several moments: primary prevention, acute phase management, rehabilitation, and secondary prevention. This review aims to evaluate and summarize the available literature on Apps for the clinical management of stroke. We described their potential and weaknesses, discussing potential room for improvement. Medline databases were interrogated for studies concerning guideline-based decision support Apps for stroke management and other medical scenarios from 2007 (introduction of the first iPhone) until January 2022. We found 551 studies. Forty-three papers were included because they fitted the scope of the review. Based on their purpose, Apps were classified into three groups: primary prevention Apps, acute stroke management Apps, and post-acute stroke Apps. We described the aim of each App and, when available, the results of clinical studies. For acute stroke, several Apps have been designed with the primary purpose of helping communication and sharing of patients’ clinical data among healthcare providers. However, interactive systems Apps aiming to assist clinicians are still lacking, and this field should be developed because it may improve stroke patients’ management.

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Section: Resultsmentioning

confidence: 99%

Section: Rehabilitation Appsmentioning

confidence: 99%

Smartphone App in Stroke Management: A Narrative Updated Review

et al. 2022

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“…NIBS techniques explore functional alterations due to stroke on cortex excitability and on plasticity propensity ( 25 ). Besides, NIBS might be applied to evaluate connectivity.…”

Section: Neurophysiological Tools To Monitor Stroke Evolutionmentioning

confidence: 99%

The role of neurophysiological tools in the evaluation of ischemic stroke evolution: a narrative review

Motolese¹,

Lanzone²,

Todisco³

et al. 2023

Front. Neurol.

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Ischemic stroke is characterized by a complex cascade of events starting from vessel occlusion. The term “penumbra” denotes the area of severely hypo-perfused brain tissue surrounding the ischemic core that can be potentially recovered if blood flow is reestablished. From the neurophysiological perspective, there are local alterations—reflecting the loss of function of the core and the penumbra—and widespread changes in neural networks functioning, since structural and functional connectivity is disrupted. These dynamic changes are closely related to blood flow in the affected area. However, the pathological process of stroke does not end after the acute phase, but it determines a long-term cascade of events, including changes of cortical excitability, that are quite precocious and might precede clinical evolution. Neurophysiological tools—such as Transcranial Magnetic Stimulation (TMS) or Electroencephalography (EEG)—have enough time resolution to efficiently reflect the pathological changes occurring after stroke. Even if they do not have a role in acute stroke management, EEG and TMS might be helpful for monitoring ischemia evolution—also in the sub-acute and chronic stages. The present review aims to describe the changes occurring in the infarcted area after stroke from the neurophysiological perspective, starting from the acute to the chronic phase.

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“…Approximately 90% of post-stroke patients experience motor deficits that lead to disability and impediments in their daily living ( Williams et al, 1999 ). Understanding the changes of beta oscillations and their functional relevance could thus help in tailoring effective rehabilitative strategies, including non-invasive brain stimulation techniques ( Motolese et al, 2022 ). Here we discuss the findings of papers on movement-related beta ERD and ERS recorded with EEG or MEG in post-stroke patients during different types of motor tasks ( Table 1 A).…”

Section: Movement-related Beta Event-related Desynchronization and Ev...mentioning

confidence: 99%

Movement-related beta ERD and ERS abnormalities in neuropsychiatric disorders

et al. 2022

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Movement-related oscillations in the beta range (from 13 to 30 Hz) have been observed over sensorimotor areas with power decrease (i.e., event-related desynchronization, ERD) during motor planning and execution followed by an increase (i.e., event-related synchronization, ERS) after the movement’s end. These phenomena occur during active, passive, imaged, and observed movements. Several electrophysiology studies have used beta ERD and ERS as functional indices of sensorimotor integrity, primarily in diseases affecting the motor system. Recent literature also highlights other characteristics of beta ERD and ERS, implying their role in processes not strictly related to motor function. Here we review studies about movement-related ERD and ERS in diseases characterized by motor dysfunction, including Parkinson’s disease, dystonia, stroke, amyotrophic lateral sclerosis, cerebral palsy, and multiple sclerosis. We also review changes of beta ERD and ERS reported in physiological aging, Alzheimer’s disease, and schizophrenia, three conditions without overt motor symptoms. The review of these works shows that ERD and ERS abnormalities are present across the spectrum of the examined pathologies as well as development and aging. They further suggest that cognition and movement are tightly related processes that may share common mechanisms regulated by beta modulation. Future studies with a multimodal approach are warranted to understand not only the specific topographical dynamics of movement-related beta modulation but also the general meaning of beta frequency changes occurring in relation to movement and cognitive processes at large. Such an approach will provide the foundation to devise and implement novel therapeutic approaches to neuropsychiatric disorders.

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New tools for shaping plasticity to enhance recovery after stroke

Cited by 14 publications

References 156 publications

Smartphone App in Stroke Management: A Narrative Updated Review

Smartphone App in Stroke Management: A Narrative Updated Review

The role of neurophysiological tools in the evaluation of ischemic stroke evolution: a narrative review

Movement-related beta ERD and ERS abnormalities in neuropsychiatric disorders

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