2017
DOI: 10.1007/s10600-017-1972-9
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New Thomimarine E from Marine Isolate of the Fungus Penicillium thomii

Abstract: The new eudesmane-type sesquiterpene thomimarine E (1) and the known compounds guaiadiol A (2) and 4,10,11-trihydroxyguaiane (3) were isolated from the marine isolate of the fungus Penicillium thomii. The structures of the compounds were established using NMR spectroscopy and high-resolution mass spectrometry. The ability of all compounds to inhibit production of NO in lipopolysaccharide-stimulated murine macrophages (RAW 264.7 line) at nontoxic concentrations was studied.

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Cited by 13 publications
(14 citation statements)
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References 22 publications
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“…Extrolites : Penicillium thomii has been reported to produce N-acetylphenylalaninol and the related 2(S)-acetamido-3-phenylpropylacetate, austalides, furan-2-carboxylic acid derivatives, guaidiol A and 4,10,11-trihydroxyguaiane, pallidopenillines, penistinraistin C and the related daldinin D, sargassopenillines, thomimarides, thomimarines, VM55599 and zesteropenillines ( Sobolevskaya et al., 2014 , Zhuravleva et al., 2014a , Zhuravleva et al., 2014b , Sobolevskaya et al., 2016a , Sobolevskaya et al., 2016b , Sobolevskaya et al., 2018 , Afiyatullov et al., 2017a , Afiyatullov et al., 2017b , Afiyatullov et al., 2018 ). Penicillium austroafricanum produces fumagillin and P .…”
Section: Resultsmentioning
confidence: 99%
“…Extrolites : Penicillium thomii has been reported to produce N-acetylphenylalaninol and the related 2(S)-acetamido-3-phenylpropylacetate, austalides, furan-2-carboxylic acid derivatives, guaidiol A and 4,10,11-trihydroxyguaiane, pallidopenillines, penistinraistin C and the related daldinin D, sargassopenillines, thomimarides, thomimarines, VM55599 and zesteropenillines ( Sobolevskaya et al., 2014 , Zhuravleva et al., 2014a , Zhuravleva et al., 2014b , Sobolevskaya et al., 2016a , Sobolevskaya et al., 2016b , Sobolevskaya et al., 2018 , Afiyatullov et al., 2017a , Afiyatullov et al., 2017b , Afiyatullov et al., 2018 ). Penicillium austroafricanum produces fumagillin and P .…”
Section: Resultsmentioning
confidence: 99%
“…The stereochemistry of C-10 in each was revised to that shown in xylariterpeneoids A 463 and B 462 respectively and both were also obtained as rst time MNPs. 202 223 Metal-stress experiments with a Penicillium strain cultured separately in the presence of each of six heavy metals, elicited production of cryptic metabolites. Culture in the presence of cobalt induced production of antibiotic polyenes 538-541.…”
Section: Cyanobacteriamentioning
confidence: 99%
“…Asperienes A-D (35)(36)(37)(38), two pairs of C-6/C-7 epimeric drimane sesquiterpene esters, were successfully isolated for the first time from the marine sediment fungus Aspergillus flavus CF13-11. All displayed significant cytotoxic activities against HeLa, MCF-7, MGC-803, and A549 cell lines, with the IC 50 values ranging from 1.4 to 8.3 µM (with cisplatin as p.c.)…”
Section: Sesquiterpenesmentioning
confidence: 99%