New therapeutic strategy: Personalization of pancreatic cancer treatment-irreversible electroporation (IRE), electrochemotherapy (ECT) and calcium electroporation (CaEP) – A pilot preclinical study

Rudno-Rudzińska, Julia; Kielan, Wojciech; Guziński, Maciej; Płochocki, Maciej; Antończyk, Agnieszka; Kulbacka, Julita

doi:10.1016/j.suronc.2021.101634

Cited by 16 publications

(11 citation statements)

References 52 publications

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“…Due to its mainly non-thermal properties, IRE preserves structures such as blood vessels and biliary tracts by sparing connective tissue and the integrity of the surrounding healthy tissue. The safety and efficacy of IRE have been investigated in several cancers [ 16 ], with the most promising overall survival (OS) and recurrence results in pancreatic [ 43 , 44 ], liver [ 45 ], and prostate cancer [ 46 , 47 ]. In particular, locally advanced pancreatic cancer represents the most immediate and biggest perspectives of IRE [ 48 ].…”

Section: Electroporationmentioning

confidence: 99%

Electroporation and Immunotherapy—Unleashing the Abscopal Effect

Justesen

Orhan

Raskov

et al. 2022

Cancers

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The discovery of electroporation in 1968 has led to the development of electrochemotherapy (ECT) and irreversible electroporation (IRE). ECT and IRE have been established as treatments of cutaneous and subcutaneous tumors and locally advanced pancreatic cancer, respectively. Interestingly, the treatment modalities have been shown to elicit immunogenic cell death, which in turn can induce an immune response towards the tumor cells. With the dawn of the immunotherapy era, the potential of combining ECT and IRE with immunotherapy has led to the launch of numerous studies. Data from the first clinical trials are promising, and new combination regimes might change the way we treat tumors characterized by low immunogenicity and high levels of immunosuppression, such as melanoma and pancreatic cancer. In this review we will give an introduction to ECT and IRE and discuss the impact on the immune system. Additionally, we will present the results of clinical and preclinical trials, investigating the combination of electroporation modalities and immunotherapy.

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Section: Electroporationmentioning

confidence: 99%

Electroporation and Immunotherapy—Unleashing the Abscopal Effect

Justesen

Orhan

Raskov

et al. 2022

Cancers

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“…In another study where 40 patients with stage III LAPC were treated with intraoperative IRE and neoadjuvant chemotherapy, 8% of the patients achieved 36 months of overall survival [ 190 ]. Several other studies have also demonstrated the enhanced efficacy when IRE was used in combination with other therapeutics [ 191 , 192 , 193 ]. Unfortunately, severe abdominal pain due to severe duodenal inflammation with wall thickening could result from IRE treatment [ 194 ].…”

Section: Locoregional Therapiesmentioning

confidence: 99%

Pancreatic Cancer: Challenges and Opportunities in Locoregional Therapies

Bazeed

Day

Garg

2022

Cancers

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Pancreatic cancer (PC) remains the seventh leading cause of cancer-related deaths worldwide and the third in the United States, making it one of the most lethal solid malignancies. Unfortunately, the symptoms of this disease are not very apparent despite an increasing incidence rate. Therefore, at the time of diagnosis, 45% of patients have already developed metastatic tumours. Due to the aggressive nature of the pancreatic tumours, local interventions are required in addition to first-line treatments. Locoregional interventions affect a specific area of the pancreas to minimize local tumour recurrence and reduce the side effects on surrounding healthy tissues. However, compared to the number of new studies on systemic therapy, very little research has been conducted on localised interventions for PC. To address this unbalanced focus and to shed light on the tremendous potentials of locoregional therapies, this work will provide a detailed discussion of various localised treatment strategies. Most importantly, to the best of our knowledge, the aspect of localised drug delivery systems used in PC was unprecedentedly discussed in this work. This review is meant for researchers and clinicians considering utilizing local therapy for the effective treatment of PC, providing a thorough guide on recent advancements in research and clinical trials toward locoregional interventions, together with the authors’ insight into their potential improvements.

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“…ECT has been established as an efficient way for the treatment of cutaneous tumors (35). For PC, ECT seemed be promising, but it was still unclear due to the small number of studies (36)(37)(38). ECT could induce systemic antitumor T-cell responses (7).…”

Section: The Effect Of Ire Combined With Immunotherapy On Pcmentioning

confidence: 99%

Immunomodulatory Effect of Irreversible Electroporation Alone and Its Cooperating With Immunotherapy in Pancreatic Cancer

et al. 2021

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Emerging studies have showed irreversible electroporation (IRE) focused on pancreatic cancer (PC). However, the effects of IRE treatment on the immune response of PC remain unknown. Moreover, there are few studies on the therapeutic effect of IRE combining with immunotherapy on PC. Thus, we review recent advances in our understanding of IRE alone and its working with immunotherapy towards the immune response of PC, discussing potential opportunities for exploring future treatment strategies.

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New therapeutic strategy: Personalization of pancreatic cancer treatment-irreversible electroporation (IRE), electrochemotherapy (ECT) and calcium electroporation (CaEP) – A pilot preclinical study

Cited by 16 publications

References 52 publications

Electroporation and Immunotherapy—Unleashing the Abscopal Effect

Electroporation and Immunotherapy—Unleashing the Abscopal Effect

Pancreatic Cancer: Challenges and Opportunities in Locoregional Therapies

Immunomodulatory Effect of Irreversible Electroporation Alone and Its Cooperating With Immunotherapy in Pancreatic Cancer

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