New therapeutic approaches to autoimmune disease

We treated 22 patients with severe aplastic anaemia refractory to antithymocyte globulin (ATG) with cyclosporine, alone or in combination with prednisone. Eight patients showed significant clinical improvement, all but one to transfusion-independence. Although cyclosporine alone was effective, the addition of prednisone resulted in prompter and fuller haematologic improvement. No patient with an absolute granulocyte count less than 0.2 x 10(9)/l responded to treatment. Haematologic remissions were sustained beyond the treatment period. Of nine patients with Diamond-Blackfan syndrome, one showed a complete response to two separate courses of cyclosporine and relapse with withdrawal of therapy, and a second achieved significant reduction in corticosteroid dose without relapse; however, seven cases failed to respond. Two of three adults with acquired pure red cell aplasia recovered. A combination of cyclosporine and corticosteroids may be effective therapy in patients with aplastic anaemia who have failed ATG treatment. Occasional cases of congenital and acquired pure red cell aplasia may also respond to cyclosporine.

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New therapeutic approaches to autoimmune disease

Cited by 4 publications

References 33 publications

Alteration in progression of murine autoimmune disease by treatment with a novel immunomodulator, SM-8849

Alteration in progression of murine autoimmune disease by treatment with a novel immunomodulator, SM-8849

The use of danazol in the therapy of immune-mediated disease of dogs

Cyclosporine therapy of aplastic anaemia, congenital and acquired red cell aplasia

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