“…Twop romising families of compounds have been most notable,i ncludingt hose with ap endant base attached to an aryl anchora nd then Mannich bases. [91,113,114,116,160] While all of these compounds were discovered independently,the structuralfeatures continuetobesimilar.W hat is conserved between both types of compounds is the basic nitrogen attached to an aromaticc ore;f or the Mannich bases, ortho substitution relative to ap henol is the most effective. Continued efforts are needed to better understand the mechanism of action for these particular types of molecules to aid in future drug design,w hether those efforts are computational and crystallographic studies or structure-activity relationships.…”