New therapeutic approach to Tourette Syndrome in children based on a randomized placebo-controlled double-blind phase IV study of the effectiveness and safety of magnesium and vitamin B6

García-López, Raquel Presa; Perea-Milla, Emilio; Garcia, Cesar Ruiz; Rivas-Ruiz, Francisco; Romero-González, Julio; Moreno, José; Faus, V.; Aguas, G. del Castillo; Diaz, Juan C Ramos

doi:10.1186/1745-6215-10-16

Cited by 18 publications

(12 citation statements)

References 41 publications

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“…Macronutrients (for example, fats [ 102 ] and proteins [ 103 ]), micronutrients (for example, minerals [ 104 ] and vitamins [ 105 ]), but also non-nutrients (for example, nutraceuticals and alcohol) are topics of interest in neuropsychiatry. Recently, the nutritional side effects of drugs (for example, alteration of orexigenic/anorexigenic signals) and drug-nutraceutical interactions revealed new insights into the understanding of the interdisciplinary approach of nutritional neuroscience.…”

Section: Discussionmentioning

confidence: 99%

Dietary Neurotransmitters: A Narrative Review on Current Knowledge

et al. 2018

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Foods are natural sources of substances that may exert crucial effects on the nervous system in humans. Some of these substances are the neurotransmitters (NTs) acetylcholine (ACh), the modified amino acids glutamate and γ-aminobutyric acid (GABA), and the biogenic amines dopamine, serotonin (5-HT), and histamine. In neuropsychiatry, progressive integration of dietary approaches in clinical routine made it necessary to discern the more about some of these dietary NTs. Relevant books and literature from PubMed and Scopus databases were searched for data on food sources of Ach, glutamate, GABA, dopamine, 5-HT, and histamine. Different animal foods, fruits, edible plants, roots, and botanicals were reported to contain NTs. These substances can either be naturally present, as part of essential metabolic processes and ecological interactions, or derive from controlled/uncontrolled food technology processes. Ripening time, methods of preservation and cooking, and microbial activity further contributes to NTs. Moreover, gut microbiota are considerable sources of NTs. However, the significance of dietary NTs intake needs to be further investigated as there are no significant data on their bioavailability, neuronal/non neuronal effects, or clinical implications. Evidence-based interventions studies should be encouraged.

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Section: Discussionmentioning

confidence: 99%

Dietary Neurotransmitters: A Narrative Review on Current Knowledge

et al. 2018

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“…Unfortunately, no published trials have yet confirmed the efficacy of any such treatments. One group has begun a trial of magnesium and vitamin B 6 [6].…”

Section: Diet and Lifestylementioning

confidence: 99%

Tourette’s Disorder

Lyon

Shprecher

Coffey

et al. 2010

Curr Treat Options Neurol

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Tourette's disorder (TD) is a common childhood-onset neuropsychiatric disorder characterized by chronic motor and vocal tics. TD frequently occurs with other neuropsychiatric disorders, such as attention deficit hyperactivity disorder (ADHD) and obsessive-compulsive disorder (OCD), and may contribute to reduced quality of life and disability. Currently available treatments to reduce tics are limited by variable clinical response and frequent adverse effects. They include alpha-2 agonists, antipsychotics (first and second generation), tetrabenazine, benzodiazepines, and habit reversal therapy. Some new and emerging (but unproven) treatments are also discussed, including topiramate and dopamine agonists. In addition, there is increasing interest in deep brain stimulation, but this is not yet ready for general use.

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“…Но следует отметить, что во всех них дозировки витаминов В превышают принятые в профилактических комплексах для детей в 2-50 раз, и наряду с вариативной клинической эффективностью они демонстрируют хорошую переносимость и безопасность. Так, например, в Испании применяли высокие дозы витамина В 6 у детей при тиках -2 мг/кг в сутки (превышение содержания в обычных комплексах в 25-50 раз) в течение 3 мес [31]. В Арканзасе (США) использовали витамин В 12 (вместе с фолиевой кислотой) у детей с аутизмом в виде подкожных инъекций в дозе 75 мкг/кг каждые 3 дня в течение 3 мес (превышение примерно в 10-20 раз): у 7 детей из 48 участников отмечались потенциально побочные проявления в виде гиперактивности и нарушений сна (при этом у 4 из них симптомы редуцировались после снижения дозировки фолиевой кислоты), и через 3 мес 78% родителей, оценив эффекты, пожелали продолжить лечение [32].…”

Section: профилактика и лечениеunclassified

Syndrome of High Academic Loads in School-Aged Children and Adolescents

et al. 2017

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1 Национальный научно-практический центр здоровья детей, Москва, Российская Федерация 2 Российская медицинская академия непрерывного профессионального образования, Москва, Российская Федерация Высокие учебные нагрузки представляют собой распространенную проблему для российских школьников, негативно влияющую на их психическое и физическое здоровье. В статье представлены основные составляющие факторы высоких учебных нагрузок, дифференцированные клинические особенности, течение и осложнения синдрома. Отдельно освещаются вопросы лечения синдрома высоких учебных нагрузок. Основной вывод заключается в необходимости усиления профилактики психоневрологических расстройств и их осложнений у учащихся российских школ. Ключевые слова: высокие учебные нагрузки, школьники, подростки, церебрастении, профилактика, лечение. (Для цитирования: Каркашадзе Г. А., Намазова-Баранова Л. С., Захарова И. Н., Макарова С. Г., Маслова О. И. Синдром высоких учебных нагрузок у детей школьного и подросткового возраста. Педиатрическая фармакология.High academic loads are a common problem for Russian schoolchildren negatively affecting their mental and physical health. The article presents the main contributory factors of high academic loads, differentiated clinical features, course, and complications of the syndrome. The issues of high academic load syndrome treatment are separately covered. The main conclusion is that it is necessary to reinforce the prevention of psychoneurological disorders and their complications in schoolchildren of Russia.

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New therapeutic approach to Tourette Syndrome in children based on a randomized placebo-controlled double-blind phase IV study of the effectiveness and safety of magnesium and vitamin B6

Cited by 18 publications

References 41 publications

Dietary Neurotransmitters: A Narrative Review on Current Knowledge

Dietary Neurotransmitters: A Narrative Review on Current Knowledge

Tourette’s Disorder

Syndrome of High Academic Loads in School-Aged Children and Adolescents

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