New tetranorlabdanoic acid from aerial parts of Salvia aethiopis

Abstract

Salvia aethiopis is a perennial plant native to Eurasia and known by the common names Mediterranean sage or African sage. This plant has been used in Iranian medicine as a carminative and tonic. The ethanolic extract of aerial part of S. aethiopis exhibited moderate to weak activity towards delta and kappa opioid receptors (46.3 and 45.3% displacement, respectively). Chromatographic purification of the ethanolic extract on silica gel column led to isolation of one new: 3α-hydroxy-8α-acetoxy-13,14,15,16-tetranorlabdan-12-oic acid (I) and three known compounds: sesquiterpene spathulenol (II), β-sitosterol (III) and β-sitosterol-3-O-glucoside (IV). The structures of all isolated compounds were elucidated by their NMR (1D and 2D) and MS spectral data. All the fractions and isolated compounds were tested for cannabinoid and opioid receptor binding assays.

A Comprehensive Review of the Classification, Sources, Phytochemistry, and Pharmacology of Norditerpenes

“…Evaluated in an NF-kB pathway luciferase assay for inhibitory effects 4.12 ± 0.61 µM [73] salvialba acid (163) Lowered the levels of ICAM-1 and VCAM-1 in HAECs induced by TNF-α 20 µM caused significant reductions in cell viability; 0.05, 0.5, 5, and 10 µM did not affect cell viability [60] cephinoid H (208) Inhibited TNF-α-induced NF-κB activation 0. Inhibited the production of NO and TNF-α in LPS-induced macrophages <25.0 µM [40,137] flickinflimilin A (446)…”

“…Compound 190 from C. sinensis exhibited effective inhibition of NF-κB activity (IC 50 4.12 ± 0.61 µM) [73]. Salvialba acid (163) has been shown to possess anti-inflammatory effects on TNF-α-induced vascular inflammation in HAECs (human aortic endothelial cells) [60].…”

A New Prenylated Isoflavonoid From Limonium leptophyllum

“…3 Previous phytochemical and biological studies on the Limonium genus have shown the presence of different classes of compounds with various biological activities. [6][7][8][9][10][11][12][13][14] In continuation of our previous work and search for novel plant-derived biological agents, 6,7,[15][16][17] 13 C NMR spectroscopic data of 1 (Table 1) were based on HSQC, heteronuclear multiple bond correlation (HMBC) correlations, and 1 H-1 H correlated spectroscopy (COSY) couplings (Figure 1). The HMBC spectrum of compound 1 showed the following key 2 J and 3 J correlations (Figure 1): H-4′′′ and H-5′′′ exhibited correlation with C-2′′′, C-3′′′, and with each other, which confirmed the attachment of methyls to C-3′′′.…”

“…3 Previous phytochemical and biological studies on the Limonium genus have shown the presence of different classes of compounds with various biological activities. 6–14 In continuation of our previous work and search for novel plant-derived biological agents, 6,7,15–17 further investigations on the phytochemical constituents of Limonium leptophyllum (Schrenk) O. Kuntze were carried out. Herein, we are reporting the isolation and characterization of 1 new and 8 known compounds from L. leptophyllum .…”