New technologies improve adenoma detection rate, adenoma miss rate, and polyp detection rate: a systematic review and meta-analysis

Castañeda, Daniel; Popov, Violeta; Verheyen, Elijah; Wander, Praneet; Gross, Seth A.

doi:10.1016/j.gie.2018.03.022

Cited by 49 publications

(35 citation statements)

References 111 publications

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“…The only device found to significantly improve ADR in this analysis was the Endocuff. In contrast to our results, Castaneda et al [32] reported a 35% increase in ADR comparing both optical (e.g., FUSE and Third Eye colonoscopy) and mechanical BFTs (e.g., Endocuff, EndoRings, and G-Eye colonoscopy) with CC. This increase in ADR may well be explained by the fact that half of the studies included in this analysis evaluated the Endocuff (previous version).…”

Section: Discussioncontrasting

confidence: 99%

“…In terms of AMR, our analysis did not show an additional effect of BFTs compared with CC. This finding clearly conflicts with the results of two previous meta-analyses that reported a 19-35% reduction in overall AMR with BFTs [32,33]. However, both meta-analyses included studies that were excluded in our analysis either because they were published before 2013 [34,35], written in German [36•], and used a previous version of the Endocuff or EndoRings [37][38][39], or because they did not use CC as a comparator [40].…”

Section: Discussioncontrasting

confidence: 59%

See 1 more Smart Citation

The Role of Behind Folds Visualizing Techniques and Technologies in Improving Adenoma Detection Rate

Keulen

Soons

Siersema

2019

Curr Treat Options Gastro

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contains supplementary material, which is available to authorized users. Keywords Colorectal cancer I Adenoma detection rate I Adenoma miss rate I Behind folds visualizing technique I Cap-assisted colonoscopy I EndoRings I Endocuff Vision I Extra Wide Angle View (EWAVE) I Full Spectrum Endoscopy (FUSE) I Third Eye Panoramic cap I Third Eye Retroscope I Scope retroflexion I Systematic review I Meta-analysis

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Section: Discussioncontrasting

confidence: 99%

Section: Discussioncontrasting

confidence: 59%

The Role of Behind Folds Visualizing Techniques and Technologies in Improving Adenoma Detection Rate

Keulen

Soons

Siersema

2019

Curr Treat Options Gastro

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“…An ongoing global, observational SBS registry (NCT01990040; EUPAS7973) is designed to provide more detailed information on the development of colon polyps in patients with SBS-IF and may lead to revision of the current regulatory guidance on surveillance colonoscopy. Newer mechanical endoscopic devices such as magnifying chromoendoscopy and magnifying narrow-band imaging have markedly improved detection of adenomas and polyps [9]. It is possible that these novel diagnostics along with histological, molecular, and stool-based techniques may be adopted, after appropriate validation, for screening and surveillance of patients treated with teduglutide.…”

Section: Discussionmentioning

confidence: 99%

Colon polyps in patients with short bowel syndrome before and after teduglutide: Post hoc analysis of the STEPS study series

et al. 2020

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Background & aims: Teduglutide promotes intestinal growth and is approved for the treatment of short bowel syndrome and intestinal failure (SBS-IF). Based on the pharmacologic activity and preclinical findings, teduglutide can potentially induce proliferative colonic mucosal changes. The aim of this study is to report the occurrence of colorectal polyps in adult patients with SBS-IF who received teduglutide in clinical studies conducted to date. Methods: A post hoc analysis of the completed Study of Teduglutide Effectiveness in Parenteral Nutrition-Dependent Short Bowel Syndrome Subjects (STEPS) clinical study series (NCT00798967, EudraCT 2008-006193-15; NCT00930644, EudraCT 2009-011679-65; NCT01560403) evaluated electronic case report form data for baseline colonoscopies (performed before treatment) and for surveillance or end-of-study (performed after treatment with teduglutide 0.05 mg/kg/day for 24 and 36 months) postexposure procedures. Results: In the STEPS studies, 73 patients treated with teduglutide had a baseline colonoscopy. No postexposure colonoscopy was scheduled in STEPS. In STEPS-2/3, 50 of 65 patients with remnant colon (77%) underwent a protocol-mandated post-exposure colonoscopy. Colon polyps were reported at baseline in 12% (9/73) of patients and post-exposure in 18% (9/50) of patients. Two had polyps both at baseline and post-exposure. On histology, available for 7 patients, 5 had adenomas (1 serrated, 4 tubular) and none had malignancy or high-grade dysplasia. Conclusion: These data support recommendations for colonoscopic screening before teduglutide therapy and subsequent on-therapy colonoscopic surveillance for patients with SBS-IF. Further studies are required to assess the risk of polyp formation in patients with SBS-IF and the most appropriate colon polyp surveillance strategies.

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“…Factors related to the adenoma detection rate (ADR) include observation time [27], use of improved devices [28], bowel preparation [29], and years of endoscopic experience [30]. In our study, we did not evaluate observation time or extent of bowel preparation.…”

Section: Discussionmentioning

confidence: 99%

Efficacy and safety of cold forceps polypectomy utilizing the jumbo cup: a prospective study

et al. 2019

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Background/Aims There are few prospective studies on cold forceps polypectomy (CFP) using jumbo cup forceps. Therefore, we examined patients with diminutive polyps (5 mm or smaller) treated with CFP using jumbo cup forceps to achieve an adenoma-free colon and also assessed the safety of the procedure and the recurrence rate of missed or residual polyp after CFP by performing follow-up colonoscopy 1 year later. Methods We included patients with up to 5 adenomas removed at initial colonoscopy and analyzed data from a total of 361 patients with 573 adenomas. One-year follow-up colonoscopy was performed in 165 patients, at which 251 lesions were confirmed. Results The one-bite resection rate with CFP was highest for lesions 3 mm or smaller and decreased significantly with increasing lesion size. Post-procedural hemorrhage was observed in 1 of 573 lesions (0.17%). No perforation was noted. The definite recurrence rate was 0.8% (2/251 lesions). The probable recurrence rate, which was defined as recurrence in the same colorectal segment, was 17%. Adenoma-free colon was achieved in 55% of patients at initial resection. Multivariate analysis revealed that achievement of an adenoma-free colon was significantly associated with number of adenomas and years of endoscopic experience. Conclusions CFP using jumbo biopsy forceps was safe and showed a high one-bite resection rate for diminutive lesions of 3 mm or smaller. The low definite recurrence rate confirms the reliability of CFP using jumbo biopsy forceps. Number of adenomas and years of endoscopic experience were key factors in achieving an adenoma-free colon.

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New technologies improve adenoma detection rate, adenoma miss rate, and polyp detection rate: a systematic review and meta-analysis

Cited by 49 publications

References 111 publications

The Role of Behind Folds Visualizing Techniques and Technologies in Improving Adenoma Detection Rate

The Role of Behind Folds Visualizing Techniques and Technologies in Improving Adenoma Detection Rate

Colon polyps in patients with short bowel syndrome before and after teduglutide: Post hoc analysis of the STEPS study series

Efficacy and safety of cold forceps polypectomy utilizing the jumbo cup: a prospective study

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