New Targets for the Identification of an Anti-Inflammatory Anti-Senescence Activity

d’Alessio, Patrizia; Bennaceur‐Griscelli, Annelise; Ostan, Rita; Franceschi, Claudio

doi:10.5772/34303

Cited by 4 publications

(2 citation statements)

References 61 publications

(61 reference statements)

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“…Monoterpenoids are believed to be capable of modifying the harmful effect of stress and NSAID on gastric injury. In an in vivo study, oral treatment with D-LIM was found to alter the mood of a group of animal undergoing non-pathological stress stimulating anxiety, in which they developed a more ludic activity ( d’Alessio et al, 2012 ). LIM could neutralize stomach acid and enhance peristaltic movements, and was indicated for the treatment of heartburn and gastro-intestinal reflux disorder ( Wilkins, 2002 ; Moraes et al, 2009 ; Patrick, 2011 ).…”

Section: Terpenoidsmentioning

confidence: 99%

Fruit-Derived Polysaccharides and Terpenoids: Recent Update on the Gastroprotective Effects and Mechanisms

et al. 2018

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Ulceration in the stomach develops in peptic ulcer disease when there is a loss of protective mucosal layers, particularly in Helicobacter pylori infection. Antibiotic therapy has failed to eradicate and impede the colonization of H. pylori. Despite given treatment, recurrent bleeding can occur and lead to death in the affected individual. The disease progression is also related to the non-steroidal inflammatory drug and stress. There are extensive research efforts to identify the gastroprotective property from various alkaloids, flavonoids, and tannins compounds from plants and marine. These natural products are believed to be safe for consumption. However, not much attention was given to summarize the carbohydrate and terpenoidal anti-ulcer compounds. Hence, this review will cover the possible mechanisms and information about acidic hydroxylans, arabinogalactan and rhamnogalacturon; and limonene, pinene, lupeol, citral, ursolic acid and nomilin to exemplify on the gastroprotective properties of polysaccharides and terpenoid, respectively, obtained from fruits. These compounds could act as a prebiotic to prevent the inhabitation of H. pylori, modulate the inflammation, suppress gastric cancer growth, and capable of stimulating the reparative mechanisms on the affected regions. Finally, this review provides the future research prospects of these natural compounds in an effort to develop new therapy for gastrointestinal tissue healing.

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Section: Terpenoidsmentioning

confidence: 99%

Fruit-Derived Polysaccharides and Terpenoids: Recent Update on the Gastroprotective Effects and Mechanisms

et al. 2018

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“…To these preliminary pre-clinical data we were recently able to add some clinical data showing the coherence of our anti-inflammatory/anti-stress approach [18,19]. The European Capacity study "Ristomed" enrolled 125 healthy individuals from three different countries (Italy, France and Germany).…”

Section: Anti-inflammaging/anti-stress Interventionmentioning

confidence: 99%