2005
DOI: 10.2174/138527205774610886
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New Synthetic Methods to 2-Pyridone Rings

Abstract: The synthesis of a substituted 2-pyridone ring is a topical area of continuing interest due to the number of biologically active molecules containing this moiety. Over the last decade, natural compounds with this structure have emerged as potent antitumor antiviral and attention, because those compounds may be studied as a simple model for investigating mechanisms of some enzymatic reactions or for discerning the behavior of nucleic acids bases in connection with mutation due to base mispairing or other mistak… Show more

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Cited by 198 publications
(71 citation statements)
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References 120 publications
(134 reference statements)
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“…Pyridines and pyridones represent an important class of these compounds because of their pharmaceutical applications [6][7][8]. The reaction of enaminones with active methylene nitriles represents one of the strategies for the preparation of 2-1H-pyridone [9][10][11]. 3-Dimethylamino-1-arylpropenones 1a-c have been extensively used in the last years by Elnagdi and coworkers for the synthesis of pyridones [12][13][14].…”
Section: Introductionmentioning
confidence: 99%
“…Pyridines and pyridones represent an important class of these compounds because of their pharmaceutical applications [6][7][8]. The reaction of enaminones with active methylene nitriles represents one of the strategies for the preparation of 2-1H-pyridone [9][10][11]. 3-Dimethylamino-1-arylpropenones 1a-c have been extensively used in the last years by Elnagdi and coworkers for the synthesis of pyridones [12][13][14].…”
Section: Introductionmentioning
confidence: 99%
“…The 1 H and 13 C NMR spectra were recorded on a Bruker ARX-300 or a Bruker DRX-400 instruments, with TMS as internal standard. The IR spectra were recorded on a INFRALUM FT-801 spectrometer.…”
Section: Methodsmentioning
confidence: 99%
“…[8][9][10][11] Methods for 2(1H)-pyridinone ring formation can be based on bi-and multicomponent reactions, intramolecular cyclizations and transformation of other hyterocycles. [12][13][14][15][16] While there are many ways of preparing 2-pyridinones, the study of new approaches to their synthesis is still desired due to the importance of this heterocycle.…”
Section: Introductionmentioning
confidence: 99%
“…One of the main synthetic strategies toward the synthesis of analogues of 3 [1][2][3] is the reaction of β-amino enones 1 with methylene active nitriles 2. [4][5][6][7][8] For the reaction of β-amino enones 1 with methylene active nitriles 2, two kinds of reaction intermediates have been considered and isolated: dienolates of type 4 [5][6][7][8][9][10][11][12][13][14] and amide derivatives Finally, amide 6 undergoes ring closure (6π electrocyclization) followed by elimination of dimethylamine to yield the 2-pyridone derivative 3.…”
Section: Introductionmentioning
confidence: 99%