New synthetic antioxidants based on caffeic acid

Abstract

Experimental details are given for the preparation of the synthetic antioxidants 1-caffeyl glycerol, 1-palmityl 2,3-dicaffeyl glycerol, and 1,2,3-tricaffeyl glycerol.

Synthesis of Some Phenylpropanoid Monoglycerides via the Mitsunobu Protocol

“…Up-to-now some phenolic monoglycerides have been prepared through a reaction of the chloride of the protected phenolic acid and isopropylidene glycerol and further removal of the isopropylidene group by acid hydrolysis in overall yields of around 6%. [ 18 ]. In comparison, the Mitsunobu reaction in combination with the deprotection step with Amberlyst gave the monoglycerides of cinnamic, ferulic and p -coumaric acids 1b-3b in overall yields of 89, 79, and 34%, respectively.…”

Hepatoprotective Activity of Polyphenolic Compounds from Cynara scolymus Against CCl4 Toxicity in Isolated Rat Hepatocytes

“…For this reason, the obtained values are probably due to a protective effect of these polyphenolic substances against CC14 cytotoxicity. In general, polyphenolic compounds and, specifically, caffeic acid and derivatives, have antioxidant properties (15). Younes and Siegers ( 16) demonstrated a protective activity in vitro against glutathione-depletion induced lipoperoxidation for quercetin, rutin, and others.…”

“…Determination of cytotoxicity induced by cci4.-After 15 min of incubación, CC14 was added in 10 µ of DMSO to hepatocyte suspensions at final concentrations of 0.5, 1, 1.5, and 2 mM, the control flasks receiving the same volume of DMSO alone. At each incubation time (5,10,15, 20, and 30 min) samples were taken for the quantification of GOT and GPT activity in a Cobas-Bio serum autoanalyzer (Roche).…”