New synthesis of substituted 3-aryl-1-naphthaldehydes

Antimalarials. 3. 3-Substituted 1-naphthalenemethanols

“…The 1-naphthalenemethanols prepared for this study are illustrated in Chart I. Synthesis of the 3-aryl-1-naphthalenemethanols (1-6) followed well-known pro-cedures18•9 from the corresponding 3-aryl-1 -naphthaldehydes, syntheses of which have been described. 10 The preparation of the 3-aryloxy (7-11) and 3-aroyl (12) derivatives required a different synthetic sequence, described elsewhere,11 for the preparation of the aldehyde precursers, the 3-bromo-1 -methylnaphthalenes. Conversion of the appropriately substituted 1 -methylnaphthalenes to the naphthaldehydes was accomplished by the steps outlined in Scheme I.…”

“…Department of Medicinal Chemistry, College of Pharmacy, University of Tennessee Center for the Health Sciences, Memphis, Tennessee 38163. Received April 10,1975 A series of diastereoisomeric 6-benzoyloxy-and 6-benzamido-2-methyldecahydroisoquinolines has been prepared and screened for antiarrhythmic effectiveness. In a continuation of our interest in identifying significant physicochemical properties of antiarrhythmic decahydroisoquinolines, octanol-water partition coefficients and pKa values have been determined for each member of the series.…”