New synthesis of polyfluoroalkanesulfonylureas

Synthesis of symmetric and dissymetric bisperfluoroalkanesulfonylimides and evaluation of their inhibition on bovine carbonic anhydrase

“…The sodium perfluoroalkanesulfonamides (1) were synthesized starting from perfluoroalkanesulfonamides and sodium methylate; their synthesis was previously described [25].…”

“…amides (1a, 1b, 1c) The synthesis of sodium perfluorobutanesulfonamide (1a) and sodium perfluorooctanesulfonamide (1c) were described previously [25]. Sodium 1,1,2,2,3,3,4,4,5,5,6,6,.…”

Synthesis and investigation of inhibition effect of fluorinated sulfonamide derivatives on carbonic anhydrase

“…The synthesis of perfluorobutanesulfonamide 1a and perfluorooctanesulfonamide 1c were described previously [15]. 2F, (CF 3 CF 2 (CF 2 ) 4 )), À122.37 (m, 2F, (CF 3 CF 2 CF 2 (CF 2 ) 3 )), À121.45 (m, 2F, (CF 3 (CF 2 ) 2 CF 2 (CF 2 ) 2 )), À119.79 (m, 2F, (CF 3 (CF 2 ) 3 CF 2 CF 2 )), À113.79 (m, 2F, (CF 3 (CF 2 ) 4 CF 2 )), À80.77 (m, 3F, (CF 3 (CF 2 ) 5 )); MS (FAB À , NBA): [M À H þ ] ¼ 398; HRMS calcd for C 6 …”

“…The filtrate was concentrated in vacuo and the residue was washed three times with diethyl ether to remove the excess of perfluoroalkanesulfonamide and then dried under vacuum. The synthesis of sodium perfluorobutanesulfonamide 2a, sodium perfluorohexanesulfonamide 2b, and perfluorooctanesulfonamide 2c were described previously [15,16].…”

The behavior of Gliclazide in solution and in the solid state: a case of organic compound presenting a solid‐solution structure

“…[6,7] Servier Laboratories introduced Gliclazide under the name Diamicron. Gliclazide has a 2008 worldwide sale of around $30 million.…”