New Successful Treatment with Disinfectant for Atopic Dermatitis

Sugimoto, Kazuo; Kuroki, Haruo; Kanazawa, Masato; Kurosaki, Takashi; Abe, Hideki; Takahashi, Yoko; Ishiwada, Naruhiko; Nezu, Yoko; Hoshioka, Akira; Toba, Tsuyoshi

doi:10.1159/000246033

Cited by 16 publications

(15 citation statements)

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“…In addition, patients were recommended to wash the face using soap 4 times a day. Steroid ointment was applied once daily to the affected areas, and moisturizing ointment was applied continuously to maintain the affected areas moist and to protect the skin barrier from destruction [1]. …”

Section: Methodsmentioning

confidence: 99%

The Importance of Bacterial Superantigens Produced by <i>Staphylococcus aureus</i> in the Treatment of Atopic Dermatitis Using Povidone-Iodine

Sugimoto¹,

Ishikawa

Terano³

et al. 2006

Dermatology

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Atopic dermatitis (AD) is frequently associated with intestinal and cervical lesions. Staphylococcus aureus produces many kinds of toxins, the bacterial superantigens. The detection rate of toxins was 80.1% from 196 S. aureus strains. Neurological examinations revealed abnormalities in 59 out of 81 AD patients. Cervical magnetic resonance imaging (MRI) was performed in 46 patients randomly and showed abnormal findings in 38 of these patients. In 23 patients who underwent MRI and duodenal biopsy, 3 were found to be normal neurologically and 2 patients showed normal duodenal tissue. However, 18 patients had abnormal findings both on neurological examination and in duodenal tissue. Serial duodenal biopsy tests were performed in 10 AD patients. In 5 patients, the findings of chronic duodenitis disappeared after the therapy with povidone-iodine. These data indicate that the therapy was effective not only for the skin lesions, but improved gastrointestinal tract lesions and cervical myelopathy, by eradicating bacterial superantigens.

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Section: Methodsmentioning

confidence: 99%

The Importance of Bacterial Superantigens Produced by <i>Staphylococcus aureus</i> in the Treatment of Atopic Dermatitis Using Povidone-Iodine

Sugimoto¹,

Ishikawa

Terano³

et al. 2006

Dermatology

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“…Comments : It is known that S. aureus is more frequently isolated on the skin lesion in patients with AD than in the healthy population and has been considered a well known exacerbation factor of AD for some time …”

Section: Cq24 Is Bleach Bath Therapy Recommended For the Treatment Omentioning

confidence: 99%

“…Evidence level: B Comments: It is known that S. aureus is more frequently isolated on the skin lesion in patients with AD than in the healthy population and has been considered a well known exacerbation factor of AD for some time. 380 Therefore, eradication of S. aureus using disinfectants (e.g. povidone iodine solution, hypochlorous acid) has been attempted for treatment of AD.…”

Section: Cq8 Is Proactive Therapy Effective In Maintaining Remissionmentioning

confidence: 99%

Clinical practice guidelines for the management of atopic dermatitis 2018

Katoh

Ohya

Ikeda

et al. 2019

The Journal of Dermatology

101

243

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Atopic dermatitis (AD) is a disease characterized by relapsing eczema with pruritus as a primary lesion. The current strategies to treat AD in Japan from the perspective of evidence‐based medicine consist of three primary measures: (i) the use of topical corticosteroids and tacrolimus ointment as the main treatment for the inflammation; (ii) topical application of emollients to treat the cutaneous barrier dysfunction; and (iii) avoidance of apparent exacerbating factors, psychological counseling and advice about daily life. The guidelines present recommendations to review clinical research articles, evaluate the balance between the advantages and disadvantages of medical activities, and optimize medical activity‐related patient outcomes with respect to several important points requiring decision‐making in clinical practice.

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“…Triclosan‐containing soap has previously been reported to result in significant clinical improvements and reductions in skin organisms 6 . Topical povidone–iodine was previously recommended as a form of topical disinfection treatment in AD 7 . A bath emollient containing triclosan and benzalkonium chloride was previously shown to achieve significant clinical improvement in patients with AD in a double‐blinded comparative study 8…”

Section: Reportmentioning

confidence: 99%

A randomized double-blind controlled trial to compare a triclosan-containing emollient with vehicle for the treatment of atopic dermatitis

Tan

Suresh²,

Tey

et al. 2010

Clinical and Experimental Dermatology

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The use of topical antiseptics in the treatment of atopic dermatitis (AD) has previously been explored. However, no triclosan-containing leave-on emollient has been evaluated previously, to our knowledge. The aims of this study were to assess the safety and efficacy of an emollient containing triclosan compared with the emollient alone (vehicle) for the treatment of AD. Eligible patients with mild to moderate AD were randomized to receive either the study cream or vehicle. All patients also received a low-potency corticosteroid cream to use during the treatment phase of the study if necessary. Patients were assessed for severity according to the SCORing Atopic Dermatitis (SCORAD) Index, amount of corticosteroid used, patient assessment of cream, and adverse events (AEs). In total, 60 patients received either the study cream or vehicle, and an intention-to-treat analysis was performed. At day 14, there was a significant decrease in SCORAD from baseline for the study cream compared with vehicle (P < 0.05). At day 27, although there was an improved mean reduction from baseline, this was no longer significant (P > 0.05). Only four patients had mild treatment-related AEs. The mean total amount of topical steroid applied by the patients using the study was significantly lower than that used by controls (P = 0.40). Triclosan-containing leave-on emollient was safe and highly acceptable to patients. However, the overall benefit on day 27 was not significant. Nevertheless, the amount of topical steroid used by patients was significantly less with the study cream than with the vehicle, thus further studies are needed to confirm its steroid-sparing effect.

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New Successful Treatment with Disinfectant for Atopic Dermatitis

Cited by 16 publications

References 0 publications

The Importance of Bacterial Superantigens Produced by <i>Staphylococcus aureus</i> in the Treatment of Atopic Dermatitis Using Povidone-Iodine

The Importance of Bacterial Superantigens Produced by <i>Staphylococcus aureus</i> in the Treatment of Atopic Dermatitis Using Povidone-Iodine

Clinical practice guidelines for the management of atopic dermatitis 2018

A randomized double-blind controlled trial to compare a triclosan-containing emollient with vehicle for the treatment of atopic dermatitis

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