New strategy for rare sugars biosynthesis: Aldol reactions using dihydroxyacetone phosphate (DHAP)-dependent aldolases

Dai, Yiwei; Zhang, Jinxiu; Jiang, Bo; Zhang, Tao; Chen, Jingjing

doi:10.1016/j.fbio.2021.101377

Cited by 8 publications

(1 citation statement)

References 76 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In theory, a set of four ketoses can be obtained by using DHAP as the donor and the same aldehyde as the receptor ( Gustavo, 2000 ). Therefore, DHAP-dependent aldolases are highly suitable for the synthesis of various rare sugars (including D-allulose, D-sorbose, D-tagatose, and L-fructose) due to their unique stereoselectivities ( Figure 5 ; Brovetto et al, 2011 ; Dai et al, 2021 ).…”

Section: Biological Production Of D-allulosementioning

confidence: 99%

Recent Advances Regarding the Physiological Functions and Biosynthesis of D-Allulose

Zhou

Gao

2022

Front. Microbiol.

View full text Add to dashboard Cite

D-Allulose, a generally regarded as safe (GRAS) sugar, is rare in nature. It is among the most promising sweeteners for future use due to its low caloric content, sucrose-like taste, and unique functions. D-Allulose has many physiological effects, such as antiobesity, antihyperglycemia, antidiabetes, anti-inflammatory, antioxidant, and neuroprotective effects. Therefore, D-allulose has important application value in the food, pharmaceutical, and healthcare industries. However, the high cost of D-allulose production limits its large-scale application. Currently, biotransformation is very attractive for D-allulose synthesis, with the two main methods of biosynthesis being the Izumoring strategy and the DHAP-dependent aldolase strategy. This article reviews recent advances regarding the physiological functions and biosynthesis of D-allulose. In addition, future perspectives on the production of D-allulose are presented.

show abstract

Section: Biological Production Of D-allulosementioning

confidence: 99%