New strains of community-acquired methicillin-resistant Staphylococcus aureus with Panton–Valentine leukocidin causing an outbreak of severe soft tissue infection in a football team

Müller-Premru, Manica; Strommenger, Birgit; Alikadic, N; Witte, Wolfgang; Friedrich, Alex; Seme, Katja; Kucina, N Svent; Smrke, Dragica; Špik, Vesna Cvitković; Gubina, Marija

doi:10.1007/s10096-005-0048-0

Cited by 57 publications

(43 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…ST 152, PVL positive, was previously reported in only 1/12 Slovenian football team members who suffered from severe soft-tissue infection (35). The second clone (F) was identical to the European CA-MRSA clone (ST 80; SCCmec IV) (20).…”

Section: Discussionmentioning

confidence: 84%

Changing Molecular Epidemiology of Methicillin-Resistant Staphylococcus aureus in a Small Geographic Area over an Eight-Year Period

et al. 2007

View full text Add to dashboard Cite

The epidemiology of methicillin-resistant Staphylococcus aureus (MRSA) at an international level shows that most MRSA strains belong to a few pandemic clones. At the local level, a predominance of one or two clones was generally reported. However, the situation is evolving and new clones are emerging worldwide, some of them with specific biological characteristics, such as the presence of Panton-Valentine leucocidin (PVL). Understanding these changes at the local and international levels is of great importance. Our objective was to analyze the evolution of MRSA epidemiology at multiple sites on a local level (Western Switzerland) over a period of 8 years. Data were based on MRSA reports from seven sentinel laboratories and infection control programs covering different areas. Pulsed-field gel electrophoresis was used to type MRSA isolates. From 1997 to 2004, a total of 2,256 patients with MRSA were reported. Results showed the presence of four predominant clones (accounting for 86% of patients), which could be related to known international clones (Berlin, New York/Japan, Southern Germany, and Iberian clones). Within the small geographic region, the 8-year follow-up period in the different areas showed spacio-temporal differences in the relative proportions of the four clones. Other international MRSA clones, as well as clones showing genetic characteristics identical to those of community-acquired MRSA (SCCmec type IV and the presence of PVL genes), were also identified but presumably did not disseminate. Despite the worldwide predominance of a few MRSA clones, our data showed that at a local level, the epidemiology of MRSA might be different from one hospital to another. Moreover, MRSA clones were replaced by other emerging clones, suggesting a rapid change.

show abstract

Section: Discussionmentioning

confidence: 84%

Changing Molecular Epidemiology of Methicillin-Resistant Staphylococcus aureus in a Small Geographic Area over an Eight-Year Period

et al. 2007

View full text Add to dashboard Cite

show abstract

“…This is an MRSA strain isolated from an abscess from a patient in Denmark in 2001 (7), and the data were deposited by Herminia de Lencastre. There are several reports in the literature linking ST152 with sporadic PVL-positive CA-MRSA infection in Central Europe (7,13,18,23,24,26), and a single sporadic MRSA ST152 isolate has been noted in Australia (3). However, to our knowledge, the current study is the first to record ST152 from an asymptomatic carriage isolate.…”

Section: Resultsmentioning

confidence: 99%

The Carriage Population of Staphylococcus aureus from Mali Is Composed of a Combination of Pandemic Clones and the Divergent Panton-Valentine Leukocidin-Positive Genotype ST152

et al. 2008

View full text Add to dashboard Cite

Staphylococcus aureus is an important human pathogen, but it appears more commonly in asymptomatic colonization of the nasopharynx than in cases of invasive disease. Evidence concerning the global population structure of S. aureus is limited by the overrepresentation in the multilocus sequence testing database of disease isolates recovered from Western Europe, the Americas, Australia, and Japan. We address this by presenting data from the S. aureus carriage population in Mali, the first detailed characterization of asymptomatic carriage from an African population. These data confirm the pandemic spread of many of the common S. aureus clones in the carriage population. We also note the high frequency (ϳ24%) of a single divergent genotype, sequence type 152 (ST152), which has not previously been recovered from nasal carriage isolates but corresponds to a sporadic Panton-Valentine leukocidin (PVL)-positive, community-acquired methicillin-resistant S. aureus clone noted mostly in Central Europe. We show that 100% of the ST152 isolates recovered from nasal carriage samples in Mali are PVL positive and discuss implications relating to the emergence and spread of this virulent genotype.

show abstract

“…The first ST152 clonal type was observed in a PVL-positive CA-MRSA isolate in Europe (Müller-Premru et al, 2005). In another study, ST152 was found to be the second most common (after ST8) clonal type among PVL-positive MRSA isolates in Austria (Krziwanek et al, 2007).…”

Section: Molecular Typing Of the Strainsmentioning

confidence: 92%

Virulence properties of methicillin-susceptible Staphylococcus aureus food isolates encoding Panton–Valentine Leukocidin gene

Sudağıdan

Aydın

2010

International Journal of Food Microbiology

View full text Add to dashboard Cite

New strains of community-acquired methicillin-resistant Staphylococcus aureus with Panton–Valentine leukocidin causing an outbreak of severe soft tissue infection in a football team

Cited by 57 publications

References 13 publications

Changing Molecular Epidemiology of Methicillin-Resistant Staphylococcus aureus in a Small Geographic Area over an Eight-Year Period

Changing Molecular Epidemiology of Methicillin-Resistant Staphylococcus aureus in a Small Geographic Area over an Eight-Year Period

The Carriage Population of Staphylococcus aureus from Mali Is Composed of a Combination of Pandemic Clones and the Divergent Panton-Valentine Leukocidin-Positive Genotype ST152

Virulence properties of methicillin-susceptible Staphylococcus aureus food isolates encoding Panton–Valentine Leukocidin gene

Contact Info

Product

Resources

About