Pyridine derivatives
Pyridine derivatives R 0380New Stereoselective Syntheses of cis-and trans-2-Methyl-4-arylpiperidines. -The reaction conditions for the stereoselective reduction of readily prepared piperidinols (III) to trans-and cis-2-methyl-4-arylpiperidines (IV) and (V) are carefully optimized. Ni-Catalysts in unpolar solvent give the trans-products preferentially, whereas palladium on carbon in ethanol results in moderate cis-selectivity. -(MERSCHAERT*, A.; DELHAYE, L.; KESTEMONT, J.-P.; BRIONE, W.; DELBEKE, P.; MANCUSO, V.; NAPORA, F.; DIKER, K.; GIRAUD, D.; VANMARSENILLE, M.; Tetrahedron Lett. 44 (2003) 24, 4531-4534; Lilly Res. Lab., Chem. Proc. R&D, Lilly Dev. Cent. S. A., B-1348 Mont St. Guibert, Belg.; Eng.) -Mais 38-116