New Spectrophotometric Estimation of Ornidazole Tablets Employing Urea as a Hydrotropic Solubilizing Additive

Maheshwari, R. K.; Srivastav, Vijay Kumar; Prajapat, Roopchand; Jain, Abhishek; Kamaria, P.; Sahu, Sandeep Sahu Sandeep

doi:10.4103/0250-474x.65024

Cited by 13 publications

(9 citation statements)

References 3 publications

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“…Hydrotropy alludes to the procedure by which a lot of solute improves the dissolvability of another intensify (the medication). They are as often as possible anionic sweetsmelling and non sweet-smelling mixes and can be once in a while impartial [6].…”

Section: Hydrotrophymentioning

confidence: 99%

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A Review on Hydrotropy: A Potential Approach for the Solubility Enhancement of Poorly Soluble Drug

Joshi¹,

NAINWAL²,

SAHARAN³

2019

Asian J Pharm Clin Res

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Solubility is one of the significant parameters to accomplish wanted centralization of medication in foundational flow for pharmacological reaction to appear. Medication adequacy can be seriously constrained by poor watery dissolvability, and a few medications additionally show reactions because of their poor solvency. There are numerous strategies which are utilized to upgrade the fluid solvency. The capacity to increment watery solvency would thus be able to be a profitable guide to expanding proficiency as well as lessening reactions for specific medications. The ability to augment watery dissolvability would subsequently have the option to be a beneficial manual for extending capability just as diminishing responses for explicit medications. Therapeutic adequacy of a medication relies on the bioavailability and at last on the solvency of medication particles. Solvency is one of the significant parameters to accomplish wanted convergence of medication in fundamental course for pharmacological reaction to appear. Because of cutting edge inquire about and advancement, there are assortments of new medications and their subordinates are accessible. In any case, over 40% of lipophilic medication up-and-comers neglect to achieve showcase because of poor bioavailability, despite the fact that these medications may display potential pharmacodynamic exercises. The lipophilic medication that achieves market requires a high portion to accomplish appropriate pharmacological activity. Hydrotropy is one of the solvency improvement methods which upgrade dissolvability to numerous folds with utilization of hydrotropes such as sodium benzoate, sodium citrate, urea, niacinamide, and so forth and have numerous focal points as, it does not require substance alteration of hydrophobic medications, utilization of natural solvents, or readiness of emulsion framework and so forth.

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Section: Hydrotrophymentioning

confidence: 99%

“…Examples of the medication discharge relied on the underlying stacking levels and the starch substance of the gels. Hence, hydrotrope-gelled starch demonstrated to be a superior vehicle for topical medication delivery [6,23,46].…”

Section: Transdermal Formulationsmentioning

confidence: 99%

A Review on Hydrotropy: A Potential Approach for the Solubility Enhancement of Poorly Soluble Drug

Joshi¹,

NAINWAL²,

SAHARAN³

2019

Asian J Pharm Clin Res

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“…Aliquot was suitably diluted with purified water and analyzed using UV spectrophotometer at 319 nm. [11] Enhancement ratios insolubility [ There was a significant enhancement in solubility of drug using a blend of urea and nicotinamide in the ratio of 1:1. Therefore, optimized combination of hydrotropes was selected for the preparation of solid dispersion.…”

Section: Determination Of Equilibrium Solubilitymentioning

confidence: 99%

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Agrawal¹

2017

IJGP

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Aim: The aim of the study was to determine the aqueous solubility of ornidazole using different hydrotropic agents then prepare a solid dispersion of ornidazole by mixed hydrotropic solubilization technique and their characterization. Materials and Methods: Equilibrium solubilities of ornidazole in different aqueous mediums were determined at room temperature. The volumetric flask was shaken on mechanical shaker for 12 h so that equilibrium solubility can be achieved and the solution was allowed to equilibrate undisturbed for 24 h. For the preparation of hydrotropic solid dispersion containing ornidazole and hydrotropic blend, minimum quantity of distilled water at 68°C-70°C contained in a 200 ml beaker was used to dissolve the urea and nicotinamide. Then, ornidazole was added to this beaker (at 35°C-40°C) and a Teflon-coated magnetic bead was dropped in it. Magnetic bead was stirring in a beaker using a magnetic stirrer, maintaining the temperature at 35°C-40°C. The prepared solid dispersions of ornidazole have been characterized by X-ray diffraction (XRD), differential scanning calorimetry (DSC), and infrared (IR) studies. Results and Discussion: The hydrotropic blend urea and nicotinamide (1:1 ratio) have been found to increase aqueous solubility of poorly water-soluble drug ornidazole. This mixed hydrotropic blend was used to prepare solid dispersion of ornidazole. DSC thermogram, XRD, and IR spectra showed that there is no interaction between drug and hydrotropic agents. Conclusion: Solid dispersions are containing a blend of urea and nicotinamide as water-soluble hydrotropic carriers show fast release of drug as compared with the pure bulk drug sample and physical mixture. The proposed techniques would be economical, convenient, and safe.

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“…Research works put forwarded many techniques for the solubility enhancement of naproxen. Several earlier workers focused on the solubility enhancement of poorly soluble naproxen by hydrotropy technique using N,N-dimethyl urea, sodium benzoate, niacinamide, ibuprofen sodium as the hydroptropy agents [10][11][12][13]. William et al investigated the process of preparing nanoparticulate system for delivery of naproxen comprising a premix of the crystalline drug substance and a surface modifier, subjecting the premix to mechanical means to reduce the particle size of the drug substance, the mechanical means producing shear, impact, cavitation and attrition [14].…”

Section: Introductionmentioning

confidence: 99%

Micellar Solubilization in the Formulation Development of Poorly Soluble Naproxen

Maheswari¹

2013

Pharmaceut Reg Affairs

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The aim of this study was to improve the dissolution rate of naproxen using micellar solubilization technology. Cloud point temperature of the nonionic surfactants has been used as the basis for the solubility study because there is better entrapment of the drug into the surfactant micelle at this temperature. Naproxen was solubilized in polysorbate 80 micelles at cloud point temperature; lactose was dissolved in micellar dispersion and the dispersion was directly spray-dried to obtain microparticles, which was subsequently converted into tablets using suitable excipients. The spray-dried particles were characterized and in-vitro dissolution studies were carried out. Spray-dried naproxen powder and tablets made out of it by direct compression method, have exhibited superior dissolution rate over controls in all media employed irrespective of pH conditions. Therefore, it is believed that the better dissolution characteristics conferred by the micellar solubilization of naproxen and rapid wetting of microparticles.

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New Spectrophotometric Estimation of Ornidazole Tablets Employing Urea as a Hydrotropic Solubilizing Additive

Cited by 13 publications

References 3 publications

A Review on Hydrotropy: A Potential Approach for the Solubility Enhancement of Poorly Soluble Drug

A Review on Hydrotropy: A Potential Approach for the Solubility Enhancement of Poorly Soluble Drug

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Micellar Solubilization in the Formulation Development of Poorly Soluble Naproxen

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