New sorbent for HPTLC–FTIR in situ determination of impurities in flurazepam

Stahlmann, Silke; Herkert, Thorsten; Röseler, Christoph; Rager, I.; Kovar, Karl‐Artur

doi:10.1016/s0928-0987(00)00192-5

Cited by 10 publications

(2 citation statements)

References 9 publications

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“…The silica gel TLC on-line method has been used to identify hydrocarbons in wastewater (203), the major marijuana metabolite in urine (on-line TLC-UV was also used) (204), impurities in chlordiazepoxide bulk drug powder and tablets (205), and impurities in flurazepam bulk drug powder and capsules (on-line TLC-UV and a specialized plate containing 50% magnesium tungstate were also used) (206). The development, techniques, and applications of HPTLC-FTIR on-line coupling have been reviewed (207).…”

Section: B Qualitative Identification Of Zonesmentioning

confidence: 99%

Basic TLC Techniques, Materials, and Apparatus

Sherma¹

2003

Handbook of Thin-Layer Chromatography

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Section: B Qualitative Identification Of Zonesmentioning

confidence: 99%

Basic TLC Techniques, Materials, and Apparatus

Sherma¹

2003

Handbook of Thin-Layer Chromatography

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“…The most recent developments include the design of a silica gel sorbent containing 50% magnesium tungstate, which considerably enhances the interpretable wavelength range (40). This allowed an efficient HPTLC-UV/FTIR coupling procedure for the separation and rapid identification of flurazepam hydrochloride and its related substances in bulk powder and capsules (41). Compared to the related compound test of the Pharmacopoeia, this procedure shows several advantages, e.g., baseline separation of the known impurities and detection of the substances as peaks in the UV region (Fig.…”

Section: B Ftir Spectramentioning

confidence: 99%

Detection, Identification, and Documentation

Kovar¹,

Morlock²

2003

Handbook of Thin-Layer Chromatography

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High‐Performance Thin‐Layer Chromatography

Cebolla

Membrado

Jarne

et al. 2015

Analytical Separation Science

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The instrumental modularity of its basic steps, that is, sample application, chromatographic development, and detection, confers HPTLC a high degree of flexibility. Automated and computer‐controlled instruments with different levels of sophistication for each of these steps have been developed, for example, spray‐on sample applicators and chambers including the possibility of gradient separation. Detection techniques such as scanning densitometers, electronic documentation systems, bioactivity detection methodologies, and online coupling with mass spectrometry have come to be easily and firmly established in laboratories. Particularly, the introduction of an elution‐based TLC – MS interface has not only allowed original and efficient hyphenated systems to be designed but also opened the possibility of expanding the connection with other detectors. Thanks to this instrumental development, HPTLC has become a reliable, accurate, and sensitive analytical technique.

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New sorbent for HPTLC–FTIR in situ determination of impurities in flurazepam

Cited by 10 publications

References 9 publications

Basic TLC Techniques, Materials, and Apparatus

Basic TLC Techniques, Materials, and Apparatus

Detection, Identification, and Documentation

High‐Performance Thin‐Layer Chromatography

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