New soft tissue filler derived from autologous keratin and fibroblast for neck wrinkles

Wang, Yue; Wang, Bingqing; Zhang, Qingguo; Ma, Jiguang

doi:10.1111/jocd.12438

Cited by 11 publications

(6 citation statements)

References 28 publications

(55 reference statements)

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“…In our previous study, this tissue-engineering filler performed well in correction of neck wrinkles, tear trough deformity, and facial scars and showed a long-time effect. 18,19,28 In this study, autologous keratin and fibroblasts were injected for static forehead rhytides correction, and the curative effect was very well. The static forehead rhytides were significantly improved within 6 months after injection, and at 24th month, there are also 91% patients showed good result, which means autologous fibroblasts and keratin have a long-term and satisfied amelioration.…”

Section: Discussionmentioning

confidence: 92%

“…8 Unfortunately, BTX-A and HA will lose effect in about 6 months and repeat injection, which became the main complain of the patinets. 18 Autologous cultured fibroblasts were accepted and used in clinical gradually.…”

Section: Discussionmentioning

confidence: 99%

“…17 In our previous study, an autologous soft filler, containing cultivated autologous fibroblasts and hair-derived keratin, acts well in correction of neck wrinkle and tear trough deformity with none complications. 18,19 In this study, the safety and effect of the filler derived from autologous fibroblasts and keratin will be evaluated in treatment for static forehead rhytides through follow-up visiting.…”

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confidence: 99%

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A new treatment for static forehead rhytides: Autologous fibroblast and keratin injection

Wang

Yang

Guan

et al. 2021

J of Cosmetic Dermatology

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Facial wrinkles are visible indicators of normal aging process, which could be seen on the skin's surface in the form of faint lines, thin creases, or deep grooves. On the forehead area, they appear in horizontal lines between eyebrows and hairline, which lead to the appearance of some negative emotions, such as stress, fatigue, and anxiety looking. These made forehead rhytides the major concern for patients as aging occurs. As the body ages, skin cell division slows down, the dermis layer begins to thin, and the fat cells beneath the dermis start to shrivel. The elastin, collagen, and fibroblasts are the main tissues providing underlying support for skin, and as the age increases, the number of the supporting tissue is gradually lost and disorganized, which made wrinkles come out. 1,2 In Lapiere's study, the loss of dermal matrix volume may also contribute to the forehead rhytides. 3 These changes in histology decreased the skin elasticity, and years of repeated pull on the skin by the underlying frontalis muscles contraction intensify the wrinkles. 4 There are many methods for static forehead rhytides correction, such as surgery, botulinum toxin type A (BTX-A) injection, soft tissue filler injection, and polydioxanone(PDO) sutures. 5,6 BTX-A combined with hyaluronic acid (HA) was widely used in clinical practice to correct the static forehead lines, because BTX-A could reduce repetitive muscle contraction and HA acts as soft tissue filler and subcutaneous collagen and matrix material. [7][8][9]

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Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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A new treatment for static forehead rhytides: Autologous fibroblast and keratin injection

Wang

Yang

Guan

et al. 2021

J of Cosmetic Dermatology

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“… Martínez et al (2016) showed that the wound healing rate of chronic leg ulcers can be increased by using hairy punch grafts. Autologous fibroblasts have been used as filler material for the nasojugal groove to correct wrinkles ( Moon et al, 2018 ) and with keratinocytes have been used for neck wrinkles ( Wang et al, 2018 ). For the gingival recession studies, collagen scaffolds with autologous fibroblast could not promote a statistically significant change ( Milinkovic et al, 2015 ).…”

Section: Clinical Uses Of Mesenchymal Stromal Cells and Fibroblastsmentioning

confidence: 99%

Comparison of similar cells: Mesenchymal stromal cells and fibroblasts

Uğurlu

Karaöz

2020

Acta Histochemica

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Almost from all organs, both mesenchymal stromal cells and fibroblasts can be isolated. Mesenchymal stromal cells (MSCs) are the most preferred cellular therapeutic agents with the regenerative potential, and fibroblasts are one of the most abundant cell types with the ability to maintain homeostasis. Because of the promising properties of MSCs, they have been well studied and their differentiation potentials, immunomodulatory potentials, gene expression profiles are identified. It has been observed that fibroblasts and mesenchymal stromal cells have similar morphology, gene expression patterns, surface markers, proliferation, differentiation, and immunomodulatory capacities. Thus, it is hard to distinguish these two cell types. Epigenetic signatures, i.e., methylation patterns of cells, are the only usable promising difference between them. Such significant similarities show that these two cells may be related to each other.

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“…Many cosmetic options exist to address the single signs of neck aging individually, but little literature exists about the safety and efficacy of combining such procedures and devices. Possible therapeutic strategies include the following: intense pulsed light, ablative and nonablative fractional lasers, microfocused ultrasound, radiofrequency, cryolipolysis, deoxycholic acid, neuromodulators, hyaluronic acid (HA) dermal fillers, calcium hydroxyapatite and the so‐called “Nefertiti lift,” which consists of injecting the platysmal bands and the inferior border of the mandible with botulinum toxin . Recently published articles stressed the importance of combining those strategies .…”

Section: Introductionmentioning

confidence: 99%

Synergic effect of plasma exeresis and non–cross‐linked low and high molecular weight hyaluronic acid to improve neck skin laxities

Paganelli

Mandel

Pellacani

et al. 2019

J of Cosmetic Dermatology

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Background: Many therapeutic options are today available for neck aging, but little evidence exists about the efficacy of combining such procedures. Nonsurgical treatment of neck laxities and wrinkles is often preferred by patients, and combined strategies are nowadays emerging as the standard of care. Both plasma exeresis and hyaluronic acid (HA) injection are two emerging techniques in this setting. Aims: To investigate the synergic effect of plasma exeresis and non-cross-linked HA injection, in stabilized hybrid complex of low and high molecular weight, in terms of both tolerability (assessed using VAS scale of pain) and improvement of neck skin laxities, according to the GAIS score assigned by patients and clinicians. Patients/Methods: Ten consecutive patients with signs of neck skin laxities (≥ type 3 according to the Glogau wrinkle scale) aged between 35 and 65 years were enrolled in our study. Two treatment sessions were performed. During the first session, both plasma exeresis and HA injection were performed. Patients were re-evauated after 30 days, and HA injection in the wrinkles of the neck was repeated. After 30 days from the second treatment session, a follow-up visit was performed to assess global efficacy of the two-step combined treatment and to monitor eventual long-term side effects. Results: A GAIS score of 1 or 2 was present in 90% of the treated cases, according to both patients and clinicians. Mean VAS value for pain was 2.4/10. Minor side effects such as erythema and/or edema were transient and completely resolved. No major adverse events were observed. Conclusions: We strongly encourage the combined treatment with plasma exeresis and non-cross-linked HA injection for its promising remodeling effects in the field of neck rejuvenation.

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New soft tissue filler derived from autologous keratin and fibroblast for neck wrinkles

Abstract: Autologous keratin and fibroblast as soft tissue filler is an effective treatment option for neck rejuvenation with long-term efficacy for reversing of skin aging.

Cited by 11 publications

References 28 publications

A new treatment for static forehead rhytides: Autologous fibroblast and keratin injection

A new treatment for static forehead rhytides: Autologous fibroblast and keratin injection

Comparison of similar cells: Mesenchymal stromal cells and fibroblasts

Synergic effect of plasma exeresis and non–cross‐linked low and high molecular weight hyaluronic acid to improve neck skin laxities

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