New small-size peptides possessing antifungal activity

Garibotto, Francisco Matías; Garro, Adriana; Masman, Marcelo F.; Rodrı́guez, Ana; Luiten, P.G.M.; Raimondi, Marcela; Zacchino, Susana; Somlai, Csaba; Penke, Botond; Enriz, Ricardo D.

doi:10.1016/j.bmc.2009.11.009

Cited by 51 publications

(29 citation statements)

References 43 publications

(55 reference statements)

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“…2 Aspergillus and Candida species are responsible for the majority of the documented infections, which may be endogenous ( Candida infections) or environmentally acquired ( Aspergillus and Cryptococcus infections). 3 Candidiasis and aspergillosis account for 80 to 90% of systemic fungal infections. 4 There are seven Candida spp.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and investigation of novel benzimidazole derivatives as antifungal agents

Chandrika

Shrestha

Ngo

2016

Bioorganic & Medicinal Chemistry

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The rise and emergence of resistance to antifungal drugs by diverse pathogenic fungal strains have resulted in an increase in demand for new antifungal agents. Various heterocyclic scaffolds with different mechanism of action against fungi have been investigated in the past. Herein, we report the synthesis and antifungal activities of 18 alkylated mono-, bis-, and trisbenzimidazole derivatives, their toxicities against mammalian cells, as well as their ability to induce reactive oxygen species (ROS) in yeast cells. Many of our bisbenzimidazole compounds exhibited moderate to excellent antifungal activities against all tested fungal strains, with MIC values ranging from 15.6–0.975 µg/mL The fungal activity profiles of our bisbenzimidazoles were found to be dependent on alkyl chain length. Our most potent compounds were found to display equal or superior antifungal activity when compared to the currently used agents amphotericin B, fluconazole, itraconazole, posaconazole, and voriconazole against many of the strains tested.

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Section: Introductionmentioning

confidence: 99%

Synthesis and investigation of novel benzimidazole derivatives as antifungal agents

Chandrika

Shrestha

Ngo

2016

Bioorganic & Medicinal Chemistry

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“…Our research group has used fish to assess the potential toxicity of different natural and/or synthetic novel drugs [7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Fish Toxicity of Commercial Herbicides Formulated With Glyphosate

Giannini¹

2013

J Environ Anal Toxicol

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“…Many fungal infections are caused by opportunistic pathogens that may be endogenous (Candida infections) or acquired from the environment (Cryptococcus, Aspergillus infections) 10 . Immune compromise can be because of ailments such as AIDS, azotemia, diabetes mellitus, neoplastic disease, lymphoma, leukemia, other hematologic cancers, burns and therapy with corticosteroids, antibiotics, immune-suppressants, or anti-metabolites.…”

Section: Methodsmentioning

confidence: 99%

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2017

IJPSR

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Statistical figures represent that fungal infections are the major cause of thousands of deaths each year. Despite the availability of treatment options invasive and systemic fungal infections have alarmingly higher mortality rates. This current review tabulates such fungal organisms that are pathogenic and fatal to human. This article provides a compilation of all Mycoses in human and also reports about the risk group of each fungus based on which, the level of risk caused by fungi can be determined. Infections caused by Dimorphic fungal pathogens (Blastomyces, Coccidioides, Marneffei) and Dematiaceous hyphomycetes (Cladophialophora, Rhinocladiella) belong to major fatal causing risk group 3 resulting in higher death rates of individuals. It also reports about various types of possible classification of mycoses i.e. based on reaction of human to fungi, host susceptibility, pathogen type, body location and risk group. The article highlights the estimated incidence of fungal diseases due to these pathogens, but these statistical figures are usually underestimated so there is a great need for advancement in understanding of fungus, their resistance along with immunity reports. In order to meet all these disease combating requirements, many high quality research initiatives with proper sources of funding and encouragement have to be provided. Article also reviews the major antifungal drugs available along with their brief pharmacokinetic profile. It also briefs some take home remedies in order to prevent and treat major fungal infection along with the alternative and novel modelling techniques developed recently for drug designing to target various development stages of fungal organism.

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New small-size peptides possessing antifungal activity

Cited by 51 publications

References 43 publications

Synthesis and investigation of novel benzimidazole derivatives as antifungal agents

Synthesis and investigation of novel benzimidazole derivatives as antifungal agents

Fish Toxicity of Commercial Herbicides Formulated With Glyphosate

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