“New” Skin Diseases in Africa

Marshall, James

doi:10.1111/j.1365-2133.1968.tb12271.x

Cited by 2 publications

(1 citation statement)

References 5 publications

(3 reference statements)

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“…Erythema is a subjective criterion impacted by skin color, and it is typically misunderstood in pigmented skin. According to studies that employ erythema as an endpoint, lighter white skin is the most vulnerable and black skin is less susceptible to contact irritants than white skin [90,91]. One explanation why black nursing home residents are 2-4 times more likely than white patients to develop decubitus ulcers has been suggested: it is challenging to recognize erythema in darker skin colors [92].…”

Section: Skin Color As It Influences Skin Functionmentioning

confidence: 99%

Influence of Ethnicities and Skin Color Variations in Different Populations: A Review

Naik

Farrukh

2021

Skin Pharmacol Physiol

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Background: In the world scientific tradition, skin color is the primary physical characteristic used to divide humans into groups. Human skin has a wide range of tones and colors, which can be seen in a wide range of demographic populations. Many factors influence the color of people’s skin, but the pigment melanin is by far the most important. Melanin is produced by cells called melanocytes in the skin and is the primary determinant of skin color in people with darker skin. Indeed, >150 genes have now been identified as having a direct or indirect effect on skin color. Vitamin D has recently been discovered to regulate cellular proliferation and differentiation in a variety of tissues, including the skin. The mechanisms through which the active vitamin D metabolite 1,25 dihydroxyvitamin D3 (or calcitriol) affects keratinocyte development are numerous and overlap with the mechanisms by which calcium influences keratinocyte differentiation. Ultraviolet (UV) is the most major modifiable risk factor for skin cancer and many other environmental-influenced skin disorders when it is abundant in the environment. Although the UV component of sunlight is known to cause skin damage, few researches have looked at the impact of non-UV solar radiation on skin physiology in terms of inflammation, and there is less information on the role of visible light in pigmentation. Summary: The quantity and quality of melanin are regulating by the expression of genes. The enzyme tyrosinase is primarily responsible for the genetic mechanism that controls human skin color. Genetics determines constitutive skin color, which is reinforced by facultative melanogenesis and tanning reactions. High quantities of melanin and melanogenic substances are typically accepted in darker skin to protect against UV radiation-induced molecular damage. Previous research has proposed that skin color variation is caused by a dynamic genetic mechanism, contributing to our understanding of how population demographic history and natural selection shape human genetic and phenotypic diversity. However, the most significant ethnic skin color difference is determined by melanin content. This current review aimed to assess the influence of skin color variations in skin structure and functions as well as difference in dermatological disease patterns. Also, this article reviewed several cases of skin color adaptation in different populations. Key Messages: Skin color impacts the composition and activity. Therefore, the contrast of dermatological ailments between distinct race-related categories is remarkable. Skin color adaptation is a challenging procedure. Refinement of skin color is an age-old craving of humans with ever-evolving drifts.

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Section: Skin Color As It Influences Skin Functionmentioning

confidence: 99%

Influence of Ethnicities and Skin Color Variations in Different Populations: A Review

Naik

Farrukh

2021

Skin Pharmacol Physiol

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Ocreiform Atrophy and Dermatitis in Kenyan Africans

Verhagen

Koten

1968

Br J Dermatol

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SUMMARY.— Dermatitis on the anterior aspect of the lower leg (“ocreiform”) is a Common condition among Africans in Kenya with distinctive clinical and histopathological features. The relationship between this dermatitis and other chronic eczematous infected conditions of the extremities, notably “dermatitis cruris pustulosa et atrophicans” described in Nigeria is discussed. The predisposing factor in Africans for dermatitis in this localization appears to be an atrophy with similar distinctive features, which was found to be present in a majority of all Kenyans over the age of 5 and is often overtreated by vigorous cosmetic procedures.

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“New” Skin Diseases in Africa

Cited by 2 publications

References 5 publications

Influence of Ethnicities and Skin Color Variations in Different Populations: A Review

Influence of Ethnicities and Skin Color Variations in Different Populations: A Review

Ocreiform Atrophy and Dermatitis in Kenyan Africans

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