New sight into interaction between endoplasmic reticulum stress and autophagy induced by vanadium in duck renal tubule epithelial cells

Wang, Li; Pan, Yueying; Yang, Fan; Guo, Xiaowang; Peng, Junjun; Wang, Xiaoyu; Fang, Yukun; Chen, Jing; Yi, Xin; Hu, Guoliang

doi:10.1016/j.cbi.2022.109981

Cited by 6 publications

(4 citation statements)

References 54 publications

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“…The extraction method of total RNA was similar to a previous study ( Wang et al, 2022 ). TRIzol reagent (Vazyme, Nanjing, China) was used to isolate the total RNA (0.05 g tissue per sample), and the purity and concentration of RNA were measured by a GeneQuant 1300 spectrophotometer.…”

Section: Methodsmentioning

confidence: 99%

“…Hence, there is a strong possibility that the mitochondria and endoplasmic reticulum in the liver are the action sites of V. A previous study reported that chronic low doses of V exposure exacerbated mitochondrial deficits, increased ROS generation and influenced Ca 2+ transport ( Delfert and Mcdonald, 1985 ). Furthermore, our previous study suggested that excessive V could cause the dilatation and swelling of the ER, which induce ER stress and autophagy ( Wang et al, 2022 ). It is proverbial that contact sites between the ER and mitochondria emerged mitochondrial-associated endoplasmic reticulum membranes ( MAMs ) as a crucial hub for various signaling pathways in the liver.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Inhibition of calcium imbalance protects hepatocytes from vanadium exposure-induced inflammation by mediating mitochondrial-associated endoplasmic reticulum membranes in ducks

Zhang,

Li,

Zhao

et al. 2023

Poultry Science

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Inhibition of calcium imbalance protects hepatocytes from vanadium exposure-induced inflammation by mediating mitochondrial-associated endoplasmic reticulum membranes in ducks

Zhang,

Li,

Zhao

et al. 2023

Poultry Science

Self Cite

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“…Inhibiting the expression of PERK can reduce autophagy. Autophagy can balance ER expansion induced by ER stress, improve cell survival rate or induce non-apoptotic death according to the environment [57]. Kawakami et al reported that treatment with the classic ER stress inducer tunicamycin resulted in a significant increase in LC3-II expression(the marker of autophagy) in the proximal renal tubular cells of the kidneys, indicating that ER stress activates autophagy [58].…”

Section: Er-associated Autophagy and Er-phagy In Kidney Diseasesmentioning

confidence: 99%

Research progress on endoplasmic reticulum homeostasis in kidney diseases

Huang

Chen

et al. 2023

Cell Death Dis

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The endoplasmic reticulum (ER) plays important roles in biosynthetic and metabolic processes, including protein and lipid synthesis, Ca2+ homeostasis regulation, and subcellular organelle crosstalk. Dysregulation of ER homeostasis can cause toxic protein accumulation, lipid accumulation, and Ca2+ homeostasis disturbance, leading to cell injury and even death. Accumulating evidence indicates that the dysregulation of ER homeostasis promotes the onset and progression of kidney diseases. However, maintaining ER homeostasis through unfolded protein response, ER-associated protein degradation, autophagy or ER-phagy, and crosstalk with other organelles may be potential therapeutic strategies for kidney disorders. In this review, we summarize the recent research progress on the relationship and molecular mechanisms of ER dysfunction in kidney pathologies. In addition, the endogenous protective strategies for ER homeostasis and their potential application for kidney diseases have been discussed.

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“…Vanadium toxicity depends on the vanadate form, oxidation state, time, dose and route of intoxication [134,135]. Accumulation of vanadium may be fatal and lead to irreversible tissue damage due to the inhibition of enzymatic processes and oxidative stress, which lead to carcinogenesis, neurotoxicity, gastrointestinal complications, infertility, lung and kidney toxicity [136].…”

Section: Vanadium Toxicitymentioning

confidence: 99%

Therapeutic Properties of Vanadium Complexes

et al. 2022

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Vanadium is a hard, silver-grey transition metal found in at least 60 minerals and fossil fuel deposits. Its oxide and other vanadium salts are toxic to humans, but the toxic effects depend on the vanadium form, dose, exposure duration, and route of intoxication. Vanadium is used by some life forms as an active center in enzymes, such as the vanadium bromoperoxidase of ocean algae and nitrogenases of bacteria. The structure and biochemistry of vanadate resemble those of phosphate, hence vanadate can be regarded as a phosphate competitor in a variety of biochemical enzymes such as kinases and phosphatases. In this review, we describe the biochemical pathways regulated by vanadium compounds and their potential therapeutic benefits for a range of disorders including type 2 diabetes, cancer, cardiovascular disease, and microbial pathology.

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New sight into interaction between endoplasmic reticulum stress and autophagy induced by vanadium in duck renal tubule epithelial cells

Cited by 6 publications

References 54 publications

Inhibition of calcium imbalance protects hepatocytes from vanadium exposure-induced inflammation by mediating mitochondrial-associated endoplasmic reticulum membranes in ducks

Inhibition of calcium imbalance protects hepatocytes from vanadium exposure-induced inflammation by mediating mitochondrial-associated endoplasmic reticulum membranes in ducks

Research progress on endoplasmic reticulum homeostasis in kidney diseases

Therapeutic Properties of Vanadium Complexes

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