New sesquiterpenoids from the stems of Dendrobium nobile and their neuroprotective activities

Ma, Chuan; Meng, Chun-Wang; Zhou, Qin‐Mei; Peng, Cheng; Liu, Fei; Zhou, Fei; Xiong, Liang

doi:10.1016/j.fitote.2019.104351

Cited by 36 publications

(15 citation statements)

References 38 publications

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“…Radiotherapy is widely used in cancer treatment; however, the benefits can be reduced by radiation-induced damage to neighboring healthy tissues. Morel et al [215] demonstrated in mice that DMAPT (11) selectively induces radio-sensitivity in prostate cancer cell-lines, while protecting primary prostate epithelial cell lines from radiation-induced damage. Compound 11 has the advantage of being well-tolerated orally without the need to adjust the administration time to radiation exposure.…”

Section: Parthenolidementioning

confidence: 99%

“…In addition, Some of these subclasses have compounds that exhibit a wide range of biological activities. These range from antitumor [9] to anti-inflammatory, including antimalarial, antimicrobial, antioxidant [10], neuroprotective [11], hepatoprotective, and immune-stimulant properties [12,13]. Regarding the structure/activity relationship of these compounds, it appears that the α-methylene-γ-lactone nucleus has a crucial role in almost all their observed biological effects, such as cytotoxic, antitrypanosomal, and anti-inflammatory actions [12,14].…”

Section: Introductionmentioning

confidence: 99%

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Applications of Sesquiterpene Lactones: A Review of Some Potential Success Cases

et al. 2020

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Sesquiterpene lactones, a vast range of terpenoids isolated from Asteraceae species, exhibit a broad spectrum of biological effects and several of them are already commercially available, such as artemisinin. Here the most recent and impactful results of in vivo, preclinical and clinical studies involving a selection of ten sesquiterpene lactones (alantolactone, arglabin, costunolide, cynaropicrin, helenalin, inuviscolide, lactucin, parthenolide, thapsigargin and tomentosin) are presented and discussed, along with some of their derivatives. In the authors’ opinion, these compounds have been neglected compared to others, although they could be of great use in developing important new pharmaceutical products. The selected sesquiterpenes show promising anticancer and anti-inflammatory effects, acting on various targets. Moreover, they exhibit antifungal, anxiolytic, analgesic, and antitrypanosomal activities. Several studies discussed here clearly show the potential that some of them have in combination therapy, as sensitizing agents to facilitate and enhance the action of drugs in clinical use. The derivatives show greater pharmacological value since they have better pharmacokinetics, stability, potency, and/or selectivity. All these natural terpenoids and their derivatives exhibit properties that invite further research by the scientific community.

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Section: Parthenolidementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Applications of Sesquiterpene Lactones: A Review of Some Potential Success Cases

et al. 2020

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“…These leaves present dehydroleucodine—SL with proven effects in the treatment of peptic gastric ulcers [ 20 ]. SL biological activities are associated with adjuvant treatments for a wide range of diseases, such as cancer and cardiovascular diseases, and neurodegenerative diseases, such as Alzheimer’s and Parkinson’s [ 21 , 22 ], as well as malaria, diarrheal, viral infections (influenza, herpes simplex virus, SARS-CoV-2)) [ 23 ], bacterial infections, migraines, and rheumatoid arthritis. They are even used to treat insect bites, presenting analgesic and sedative effects [ 24 , 25 , 26 ].…”

Section: Sesquiterpene Lactones and Their Structure–activity Relation...mentioning

confidence: 99%

Anti-Inflammatory and Immunoregulatory Action of Sesquiterpene Lactones

et al. 2022

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Sesquiterpene lactones (SL), characterized by their high prevalence in the Asteraceae family, are one of the major groups of secondary metabolites found in plants. Researchers from distinct research fields, including pharmacology, medicine, and agriculture, are interested in their biological potential. With new SL discovered in the last years, new biological activities have been tested, different action mechanisms (synergistic and/or antagonistic effects), as well as molecular structure–activity relationships described. The review identifies the main sesquiterpene lactones with interconnections between immune responses and anti-inflammatory actions, within different cellular models as well in in vivo studies. Bioaccessibility and bioavailability, as well as molecular structure–activity relationships are addressed. Additionally, plant metabolic engineering, and the impact of sesquiterpene lactone extraction methodologies are presented, with the perspective of biological activity enhancement. Sesquiterpene lactones derivatives are also addressed. This review summarizes the current knowledge regarding the therapeutic potential of sesquiterpene lactones within immune and inflammatory activities, highlighting trends and opportunities for their pharmaceutical/clinical use.

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“…D. nobile polysaccharide had an antiviral effect and had broad development prospects ( Li Z. et al, 2020 ). D. nobile sesquiterpenes had physiological activities in neuroprotection, immune regulation, and antitumor ( Ma et al, 2019 ). Among the Dendrobium recorded in the Pharmacopoeia of the People’s Republic of China, only D. nobile has the ability of treating weakness of the five internal organs, strengthening Yin and benefiting essence, holding thick stomach for a long time, and tonifying the kidney and benefiting power, and the alkaloid content in D. nobile was the highest among all herbs of Dendrobium , which was the main source of medicinal Dendrobium ( Wang, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Transcriptome and Metabonomics Analysis Revealed the Molecular Mechanism of Differential Metabolite Production of Dendrobium nobile Under Different Epiphytic Patterns

Liu

Huang

et al. 2022

Front. Plant Sci.

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The cultivation medium of Dendrobium nobile has an effect on the contents of its main medicinal components, but the specific mechanism is still unclear. In this study, the callus, seedlings, rhizomes, and leaves of D. nobile were sequenced for the PacBio SMRT. The 2-year-old stems were selected for the Illumina sequencing and metabolome sequencing to analyze the genetic mechanism of metabolic differences under different epiphytic patterns. As a result, a total of 387 differential genes were obtained, corresponding to 66 differential metabolites. Different epiphytic patterns can induce a series of metabolic changes at the metabolome and transcriptome levels of D. nobile, including flavonoid metabolism, purine metabolism, terpenoid backbone biosynthesis, amino acid metabolism, and alpha-linolenic acid metabolic, and related regulatory genes include ALDH2B7, ADC, EPSPS-1, SHKA, DHAPS-1, GES, ACS1, SAHH, ACS2, CHLP, LOX2, LOX2.3, and CYP74B2. The results showed that the genetic mechanism of D. nobile under various epiphytic patterns was different. In theory, the content of metabolites under the epiphytic patterns of Danxia stone is higher, which is more suitable for field cultivation.

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New sesquiterpenoids from the stems of Dendrobium nobile and their neuroprotective activities

Cited by 36 publications

References 38 publications

Applications of Sesquiterpene Lactones: A Review of Some Potential Success Cases

Applications of Sesquiterpene Lactones: A Review of Some Potential Success Cases

Anti-Inflammatory and Immunoregulatory Action of Sesquiterpene Lactones

Transcriptome and Metabonomics Analysis Revealed the Molecular Mechanism of Differential Metabolite Production of Dendrobium nobile Under Different Epiphytic Patterns

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