New sesquiterpene–monoterpene lactone, artemisolide, isolated from Artemisia argyi

Kim, Jong Han; Kim, Hae-Kyung; Jeon, Sun Bok; Son, Kwang‐Hee; Kim, Eun Hee; Kang, Sung Kwon; Sung, Nack‐Do; Kwon, Byoung‐Mog

doi:10.1016/s0040-4039(02)01315-1

Cited by 72 publications

(39 citation statements)

References 6 publications

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“…These results were in agreement with previous studies that showed that SLAK exerted an anti-inflammatory effect in J774A.1 macrophages through the inhibition of NO and PGE 2 production as well iNOS and COX-2 expression (Emami et al, 2010). Moreover, the overall impact of these changes also reflect results of previous studies that demonstrated that various individual sesquiterpene compounds from Artemisia exert anti-inflammatory effects that may be effective in treating some types of experimental inflammation/autoimmune conditions (Choi et al, 2011;Ho et al, 2014;Kim et al, 2002;Lu et al, 2009;Omer et al, 2007;Sun et al, 2010;Yang et al, 2012).…”

Section: Discussionsupporting

confidence: 92%

“…Different classes of chemicals, e.g., coumarins, terpenes, sesquiterpenes, flavonoids, aromatics, dipeptides, phenolics, esterols, germacranolides, secoguaianolides, and several polysaccharides have been isolated from Artemisia species (Valless et al, 2011). In recent years, increasing evidence has shown that sesquiterpene lactones are one of the constituents that impart a wide-range of pharmacological effects, including anti-cancer and immunomodulatory actions (Choi et al, 2011;Kim et al, 2002;Lu et al, 2009;Yang et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

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In vitroimmunomodulatory properties of a sesquiterpene lactone-bearing fraction fromArtemisia khorassanica

Rabe¹,

Iranshahi

Rastin³

et al. 2014

Journal of Immunotoxicology

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Artemisia species are important medicinal plants throughout the world. The present in vitro study, using a sesquiterpene lactone-bearing fraction prepared from Artemisia khorassanica (SLAK), sought to investigate immunomodulatory/anti-inflammatory properties of this plant and elucidate potential underlying mechanisms for the actions. Effects of the SLAK on mitogeninduced murine splenocyte proliferation and interleukin (IL)-4 and interferon (IFN)-secretion were evaluated. To assess anti-inflammatory activities, levels of inducible of nitric oxide (NO) and prostaglandin E 2 (PGE 2 ), as well as expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), in peritoneal macrophages was examined. The results showed that SLAK noticeably was capable of suppressing PHA/LPS-stimulated splenocyte proliferation and of up-regulating production of the T-helper (T H )-2 cell cytokine IL-4 while down-regulating formation of T H 1 IFN. In addition, while SLAK caused negligible proliferation inhibition, peritoneal macrophages displayed considerable decrease in NO and PGE 2 production along with iNOS and COX-2 expression. The current experiment shows Artemisia khorasanica -a traditionally used herb -may have immunomodulatory and anti-inflammatory effects. It is anticipated that the ingredients may be employed as therapeutic candidates in the regulation of some immune responses implicated in various conditions and ailments.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

In vitroimmunomodulatory properties of a sesquiterpene lactone-bearing fraction fromArtemisia khorassanica

Rabe¹,

Iranshahi

Rastin³

et al. 2014

Journal of Immunotoxicology

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“…Although studies of the efficacy of A. princeps and A. argyi as medicinal herbs have been conducted, 16,17) there has yet to be any reported study on the classification of any Artemisia herbs used as medicinal materials in Korea, China, and Japan.…”

Section: Discussionmentioning

confidence: 99%

Development of SCAR Marker for Discrimination of Artemisia princeps and A. argyi from Other Artemisia Herbs

Lee

Doh

Park

et al. 2006

Biological & Pharmaceutical Bulletin

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“…The genus Artemisia L., one of the largest and most widely distributed genera of the family Asteraceae, comprises about 200-400 species of herbs and shrubs, the most notable being A. annua for producing the antimalarial drug artemisinin (Lee et al, 2000;Kim et al, 2002;GRIN Database, 2010). Artemisia species are distributed in the northern hemisphere, especially, along the Mediterranean coast of Europe, Southwest of Asia and Africa (Trease & Evans, 2002;Salido et al, 2004;Ferchichi et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

“…This genus, with its common Persian name "Dermane" and the common English name "Wormwood", includes approximately 34 species that are found wild all over Iran (Mozaffarian, 1996;Ghasemi et al, 2007). Several coumarins, flavonoids, phenylpropanoids, sterols and terpenoids (specially sesquiterpenes and monoterpenes), and their glycosides were isolated from this genus, and shown to have antimalarial, antiviral, antitumor, antipyretic, antihaemorrhagic, anticoagulant, antiinflammatory, antioxidant, antihepatitis, antiulcerogenic, antispasmodic and anticomplementary activities (Kim et al, 2002;Lee et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of antimalarial, free-radical-scavenging and insecticidal activities of Artemisia scoparia and A. Spicigera, Asteraceae

Afshar¹,

Delazar²,

Janneh³

et al. 2011

Rev. bras. farmacogn.

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Artemisia species (Asteraceae), widespread throughout the world, are a group of important medicinal plants. The extracts of two medicinal plants of this genus, Artemisia scoparia Waldst. & Kit. and A. spicigera C. Koch, were evaluated for potential antimalarial, free-radical-scavenging and insecticidal properties, using the heme biocrystallisation and inhibition assay, the DPPH assay and the contact toxicity bioassay using the pest Tribolium castaneum, respectively. The methanol extracts of both species showed strong free-radical-scavenging activity and the RC50 values were 0.0317 and 0.0458 mg/mL, respectively, for A. scoparia and A. spicigera. The dichloromethane extracts of both species displayed a moderate level of potential antimalarial activity providing IC50 at 0.778 and 0.999 mg/mL for A. scoparia and A. spicigera, respectively. Both species of Artemisia showed insecticidal properties. However, A. spicigera was more effective than A. scoparia.

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New sesquiterpene–monoterpene lactone, artemisolide, isolated from Artemisia argyi

Cited by 72 publications

References 6 publications

In vitroimmunomodulatory properties of a sesquiterpene lactone-bearing fraction fromArtemisia khorassanica

In vitroimmunomodulatory properties of a sesquiterpene lactone-bearing fraction fromArtemisia khorassanica

Development of SCAR Marker for Discrimination of Artemisia princeps and A. argyi from Other Artemisia Herbs

Evaluation of antimalarial, free-radical-scavenging and insecticidal activities of Artemisia scoparia and A. Spicigera, Asteraceae

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