New Semi-IPN Hydrogels Based on Cellulose for Biomedical Application

Bajpai, S. K.; Swarnkar, M. P.

doi:10.1155/2014/376754

Cited by 13 publications

(5 citation statements)

References 31 publications

(30 reference statements)

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“…Cellulose has found particular favor in biomedical sciences due to its mechanical strength, biocompatibility, and hydrophilicity, making it a promising polysaccharide for the production of biocompatible porous cryogels [10][11][12]. Cellulose-based materials have been proposed for a variety of biomedical applications [13,14] because, unlike other polysaccharides, cellulose is relatively bioinert and is not biodegraded in the human body.…”

Section: Introductionmentioning

confidence: 99%

Cellulose Cryogels as Promising Materials for Biomedical Applications

Tyshkunova

Poshina

Skorik

2022

IJMS

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The availability, biocompatibility, non-toxicity, and ease of chemical modification make cellulose a promising natural polymer for the production of biomedical materials. Cryogelation is a relatively new and straightforward technique for producing porous light and super-macroporous cellulose materials. The production stages include dissolution of cellulose in an appropriate solvent, regeneration (coagulation) from the solution, removal of the excessive solvent, and then freezing. Subsequent freeze-drying preserves the micro- and nanostructures of the material formed during the regeneration and freezing steps. Various factors can affect the structure and properties of cellulose cryogels, including the cellulose origin, the dissolution parameters, the solvent type, and the temperature and rate of freezing, as well as the inclusion of different fillers. Adjustment of these parameters can change the morphology and properties of cellulose cryogels to impart the desired characteristics. This review discusses the structure of cellulose and its properties as a biomaterial, the strategies for cellulose dissolution, and the factors affecting the structure and properties of the formed cryogels. We focus on the advantages of the freeze-drying process, highlighting recent studies on the production and application of cellulose cryogels in biomedicine and the main cryogel quality characteristics. Finally, conclusions and prospects are presented regarding the application of cellulose cryogels in wound healing, in the regeneration of various tissues (e.g., damaged cartilage, bone tissue, and nerves), and in controlled-release drug delivery.

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Section: Introductionmentioning

confidence: 99%

Cellulose Cryogels as Promising Materials for Biomedical Applications

Tyshkunova

Poshina

Skorik

2022

IJMS

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“…Similarly, Erizel 30 prepared starch–poly(acrylamide-co-acrylic acid) hydrogels by gamma radiations and found that GF decreased with starch contents. However, the opposite trend was observed in the case of radiation-induced CMC/acrylamide co-polymeric hydrogels, 31 where the CMC content of 2%, 3%, and 5% showed GF values of 0.30, 0.55, and 0.65, respectively. We also determined GF of semi-IPNs having varying amounts of cross-linking agents (i.e.…”

Section: Resultsmentioning

confidence: 87%

“…In a recent work, 38 superabsorbent hydrogels, consisting of CMC-g-poly(acrylic acid-co-acrylamido-2-methylpropanesulfonic acid), have demonstrated k 2 values in the order of 10 −2 (g/g min) −1 . Most recently, we 31 reported values of k 2 in the range of 0.228–3.88 × 10 −3 (g/g min) −1 for cellulose/poly(sodium acrylate) semi-IPNs. It is also clear from the data shown in Table 2 that the theoretical and experimental ESR do not show fair agreement and ESR (theo) is greater than ESR (exp) .…”

Section: Swelling Behavior Of Semi-ipn Samplesmentioning

confidence: 99%

Microwave-assisted synthesis of carboxymethyl psyllium and its development as semi-interpenetrating network with poly(acrylamide) for gastric delivery

Bajpai

Chand

Agrawal

2015

Journal of Bioactive and Compatible Polymers

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In this study, microwave-induced synthesis of carboxymethyl psyllium is reported. The carboxymethyl psyllium was characterized by Fourier transform infrared, X-ray diffraction, thermogravimetric analysis, scanning electron microscopy, and proton nuclear magnetic resonance spectroscopic analysis. It also showed fair antibacterial activity against model bacteria Escherichia coli, thus confirming its bioactivity. Its semi-interpenetrating polymer network hydrogels with poly(acrylamide) were synthesized and investigated for their swelling behavior in simulating gastric fluid at 37°C. The swelling ratio strongly depended on the degree of cross-linking and ratio of psyllium to acrylamide in the feed mixture. The kinetic water uptake data were interpreted by various kinetic models, and the order of fitness for these models was as follows: Power model > First-order model ≈ Schott model.

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“…Además, deben tener la capacidad de liberar sustancias terapéuticas de forma controlada y poseer alta biocompatibilidad 8 . Una estrategia para la obtención de estos materiales es la formación de matrices de redes poliméricas semi-interpenetradas (semi-IPN) a base de polímeros naturales y sintéticos 9 . Los polímeros naturales como el colágeno y los polisacáridos como la pectina permiten mantener y regular la biocompatibilidad de los hidrogeles 10,11 .…”

Section: Introductionunclassified

Evaluación de la biocompatibilidad de redes semi-interprenetadas de colágeno-poliuretano-pectina

et al. 2023

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En la presente investigación se diseñaron hidrogeles a base de redes poliméricas semi-interpenetradas (semi-IPN) de colágeno-poliuretano-pectina, con diferente concentración de pectina (10-40 %m) y se evaluó su efecto en la biocompatibilidad in vitro. La pectina utilizada en este trabajo fue extraída enzimáticamente a partir de cáscaras de naranja. Los parámetros peso equivalente, acidez libre, porcentaje de metoxilo, grado de esterificación y porcentaje de ácido anhídrido galacturónico (AAG) de la pectina fueron determinados de acuerdo con la metodología propuesta por Owens1. Los hidrogeles fueron caracterizados por FTIR y SEM. Además, se evaluó el grado de entrecruzamiento, hinchamiento y módulo de almacenamiento de los hidrogeles. La biocompatibilidad de los hidrogeles se evaluó a través de ensayos de viabilidad celular con monocitos y fibroblastos. Además, se evaluó la actividad hemolítica de los hidrogeles. Altas concentraciones de pectina disminuyen la capacidad de hinchamiento significativamente, y promueven una ligera mejora de la reticulación y un incremento significativo del módulo de almacenamiento de la matriz semi-IPN. La caracterización por FTIR y SEM confirmó la formación de redes semi-interpenetradas de colágeno-poliuretano-pectina. Los hidrogeles formulados no poseen carácter citotóxico. El porcentaje de viabilidad de fibroblastos alcanzó el 75% mientras que la viabilidad de monocitos alcanzó el 105% hasta por 48 h de incubación. Las formulaciones que contienen 10 y 20 %m de pectina mostraron mejor biocompatibilidad in vitro, ya que la presencia de altas regiones granulares semi-interpenetradas en la matriz colágeno-poliuretano muestran impactar en el metabolismo celular.

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New Semi-IPN Hydrogels Based on Cellulose for Biomedical Application

Cited by 13 publications

References 31 publications

Cellulose Cryogels as Promising Materials for Biomedical Applications

Cellulose Cryogels as Promising Materials for Biomedical Applications

Microwave-assisted synthesis of carboxymethyl psyllium and its development as semi-interpenetrating network with poly(acrylamide) for gastric delivery

Evaluación de la biocompatibilidad de redes semi-interprenetadas de colágeno-poliuretano-pectina

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